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• W4384937112 endingPage "104775" @default.
• W4384937112 startingPage "104775" @default.
• W4384937112 abstract "Naringenin (NAR) has recently been proven to exert antituberculosis activity (anti-TB); however, because of its poor solubility and limited oral bioavailability, this is not enough for its oral therapeutic effectiveness. This study aims to load NAR into emulsomal nanoparticles to improve its oral bioavailability and boost its anti-TB activity. Eight formulae were developed by 23 two-level full factorial design analysis with three independent variables: the weight of tripalmitin in mg, the weight of cholesterol in mg, and the presence of 1% (v/v) Tween 80. Thin-film hydration (THF) coupled with water-bath sonication was used to develop NAR-loaded emulsomes (EMLs), followed by their physical characterization. The optimized formula (F5) was determined based on maximum entrapment efficiency % (80.5 ± 3.4%), maximum zeta potential (−38.5 ± 1.9 mv), minimum particle size (208.5 ± 10.1 nm), and polydispersity index (0.35 ± 0.00). The percentage of NAR released from F5 reached 98.75 ± 1% for up to 24 h, compared to a 55.60 ± 2.95% release from NAR suspension. The cytotoxicity studies indicated the safety of NAR and NAR-loaded EMLs below 100 μg/ml. The optimized NAR-EMLs formula exhibited superior permeability through the developed caco-2 cells by 2.86 and 4.47 folds compared to pure NAR after 30 and 120 min, respectively. The minimum inhibitory concentration of NAR-EMLs studied on mycobacterium bovis (M. bovis) strains was 0.08 μg/ml, which inhibited the growth of M. bovis five folds more than the pure NAR and the standard antitubercular drug (ethambutol dihydrochloride). Consequently, NAR-EMLs may be viewed as novel anti-mycobacterial nanocarriers of NAR offering a novel strategy for oral tuberculosis (TB) management." @default.
• W4384937112 created "2023-07-22" @default.
• W4384937112 creator A5048388550 @default.
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• W4384937112 date "2023-09-01" @default.
• W4384937112 modified "2023-09-25" @default.
• W4384937112 title "Phytomedicinal flavonoid loaded phospholipid sheathed lipidic nano-carriers as a platform with boosted oral anti-mycobacterium activity" @default.
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• W4384937112 doi "https://doi.org/10.1016/j.jddst.2023.104775" @default.
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