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- W4384937851 endingPage "879" @default.
- W4384937851 startingPage "867" @default.
- W4384937851 abstract "Abstract The mechanisms of carcinogenesis are extremely complex and involve multiple components that contribute to the malignant cell transformation, tumor growth, and metastasis. In recent decades, there has been a growing interest in the role of symbiotic human microbiota in the regulation of metabolism and functioning of host immune system. The symbiosis between a macroorganism and its microbiota has given rise to the concept of a holoorganism. Interactions between the components of a holoorganism have formed in the process of coevolution, resulting in the acquisition by microbiotic metabolites of a special role of signaling molecules and main regulators of molecular interactions in the holoorganism. As elements of signaling pathways in the host organism, bacterial metabolites have become essential participants in various physiological and pathological processes, including tumor growth. At the same time, signaling metabolites often exhibit multiple effects and impact both the functions of the host cells and metabolic activity and composition of the microbiome. This review discusses the role of microbiotic metabolites in the induction and prevention of malignant transformation of cells in the host organism and their impact on the efficacy of anticancer therapy, with special emphasis on the involvement of some components of the microbial metabolite molecular ensemble in the initiation and progression of tumor growth." @default.
- W4384937851 created "2023-07-22" @default.
- W4384937851 creator A5055801819 @default.
- W4384937851 creator A5056125959 @default.
- W4384937851 creator A5073081371 @default.
- W4384937851 date "2023-07-01" @default.
- W4384937851 modified "2023-10-16" @default.
- W4384937851 title "Molecular Ensembles of Microbiotic Metabolites in Carcinogenesis" @default.
- W4384937851 cites W1981266729 @default.
- W4384937851 cites W1993970282 @default.
- W4384937851 cites W2012072922 @default.
- W4384937851 cites W2032382941 @default.
- W4384937851 cites W2048994952 @default.
- W4384937851 cites W2059128083 @default.
- W4384937851 cites W2080598921 @default.
- W4384937851 cites W2087905758 @default.
- W4384937851 cites W2111642319 @default.
- W4384937851 cites W2124632458 @default.
- W4384937851 cites W2131536322 @default.
- W4384937851 cites W2165456770 @default.
- W4384937851 cites W2180333272 @default.
- W4384937851 cites W2185075416 @default.
- W4384937851 cites W2193435259 @default.
- W4384937851 cites W2337601214 @default.
- W4384937851 cites W2520134471 @default.
- W4384937851 cites W2528306813 @default.
- W4384937851 cites W2529195559 @default.
- W4384937851 cites W2625811471 @default.
- W4384937851 cites W2655728305 @default.
- W4384937851 cites W2765314233 @default.
- W4384937851 cites W2766960310 @default.
- W4384937851 cites W2770359150 @default.
- W4384937851 cites W2772709000 @default.
- W4384937851 cites W2788222993 @default.
- W4384937851 cites W2789769337 @default.
- W4384937851 cites W2793543050 @default.
- W4384937851 cites W2797443945 @default.
- W4384937851 cites W2804448077 @default.
- W4384937851 cites W2807658783 @default.
- W4384937851 cites W2811267341 @default.
- W4384937851 cites W2883186768 @default.
- W4384937851 cites W2883967352 @default.
- W4384937851 cites W2887026479 @default.
- W4384937851 cites W2893693165 @default.
- W4384937851 cites W2900456357 @default.
- W4384937851 cites W2902640082 @default.
- W4384937851 cites W2908611000 @default.
- W4384937851 cites W2913097383 @default.
- W4384937851 cites W2921161668 @default.
- W4384937851 cites W2927581250 @default.
- W4384937851 cites W2939948226 @default.
- W4384937851 cites W2983769545 @default.
- W4384937851 cites W2989467288 @default.
- W4384937851 cites W2990182987 @default.
- W4384937851 cites W2991085179 @default.
- W4384937851 cites W2993795216 @default.
- W4384937851 cites W2999094514 @default.
- W4384937851 cites W3000635571 @default.
- W4384937851 cites W3007328008 @default.
- W4384937851 cites W3007924994 @default.
- W4384937851 cites W3018344612 @default.
- W4384937851 cites W3022450273 @default.
- W4384937851 cites W3045114299 @default.
- W4384937851 cites W3048667905 @default.
- W4384937851 cites W3090094696 @default.
- W4384937851 cites W3106005610 @default.
- W4384937851 cites W3107083588 @default.
- W4384937851 cites W3110077847 @default.
- W4384937851 cites W3112428671 @default.
- W4384937851 cites W3113179625 @default.
- W4384937851 cites W3133087649 @default.
- W4384937851 cites W3135899488 @default.
- W4384937851 cites W3158890392 @default.
- W4384937851 cites W3162040744 @default.
- W4384937851 cites W3163165279 @default.
- W4384937851 cites W3173553906 @default.
- W4384937851 cites W3180882235 @default.
- W4384937851 cites W3185129863 @default.
- W4384937851 cites W3196604154 @default.
- W4384937851 cites W4200118286 @default.
- W4384937851 cites W4200513721 @default.
- W4384937851 cites W4206767557 @default.
- W4384937851 cites W4206976415 @default.
- W4384937851 cites W4220731595 @default.
- W4384937851 cites W4223450145 @default.
- W4384937851 cites W4225424088 @default.
- W4384937851 cites W4225529913 @default.
- W4384937851 cites W4281729985 @default.
- W4384937851 cites W4283832501 @default.
- W4384937851 cites W4286209076 @default.
- W4384937851 cites W4297265218 @default.
- W4384937851 cites W4304191442 @default.
- W4384937851 cites W4307338693 @default.
- W4384937851 cites W4307865042 @default.
- W4384937851 cites W4311489384 @default.
- W4384937851 doi "https://doi.org/10.1134/s0006297923070027" @default.
- W4384937851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37751860" @default.
- W4384937851 hasPublicationYear "2023" @default.