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• W4384938400 abstract "Autophagy is a cellular process in which proteins and organelles are engulfed in autophagosomal vesicles and transported to the lysosome/vacuole for degradation. Protein‒protein interactions (PPIs) play a crucial role at many stages of autophagy, which present formidable but attainable targets for autophagy regulation. Moreover, selective regulation of PPIs tends to have a lower risk in causing undesired off-target effects in the context of a complicated biological network. Thus, small-molecule regulators, including peptides and peptidomimetics, targeting the critical PPIs involved in autophagy provide a new opportunity for innovative drug discovery. This article provides general background knowledge of the critical PPIs involved in autophagy and reviews a range of successful attempts on discovering regulators targeting those PPIs. Successful strategies and existing limitations in this field are also discussed." @default.
• W4384938400 created "2023-07-22" @default.
• W4384938400 creator A5001876116 @default.
• W4384938400 creator A5019891864 @default.
• W4384938400 creator A5043764158 @default.
• W4384938400 creator A5048655177 @default.
• W4384938400 creator A5078629424 @default.
• W4384938400 date "2023-07-01" @default.
• W4384938400 modified "2023-10-14" @default.
• W4384938400 title "Drug discovery by targeting the protein–protein interactions involved in autophagy" @default.
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