Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384938976> ?p ?o ?g. }
- W4384938976 endingPage "125915" @default.
- W4384938976 startingPage "125915" @default.
- W4384938976 abstract "Non-covalent interactions in bio-macromolecules are individually weak but collectively important. How they take a concerted action in a complex biochemical reaction network to realize their thermal stability and activity is still challenging to study. Here graph theory was used to investigate how the temperature-dependent non-covalent interactions as identified in the 3D structures of the thermo-gated capsaicin receptor TRPV1 could form a systemic fluidic grid-like mesh network with topological grids constrained as the thermo-rings to govern heat-sensing. The results showed that the heat-evoked melting of the biggest grid initiated a matched temperature threshold to release the lipid from the active vanilloid site for channel activation. Meanwhile, smaller grids were required to stabilize heat efficacy. Altogether, the change in the total grid sizes upon the change in the total noncovalent interactions along the lipid-dependent gating pathway was necessary for the matched temperature sensitivity. Therefore, this grid thermodynamic model may be broadly significant for the structural thermostability and the functional thermoactivity of bio-macromolecules." @default.
- W4384938976 created "2023-07-22" @default.
- W4384938976 creator A5066971089 @default.
- W4384938976 date "2023-09-01" @default.
- W4384938976 modified "2023-10-16" @default.
- W4384938976 title "Thermoring-based heat activation switches in the TRPV1 biothermometer" @default.
- W4384938976 cites W1511198581 @default.
- W4384938976 cites W1973796039 @default.
- W4384938976 cites W1974641725 @default.
- W4384938976 cites W2007034094 @default.
- W4384938976 cites W2007572995 @default.
- W4384938976 cites W2011295158 @default.
- W4384938976 cites W2014389293 @default.
- W4384938976 cites W2034339598 @default.
- W4384938976 cites W2037651260 @default.
- W4384938976 cites W2040222426 @default.
- W4384938976 cites W2052870492 @default.
- W4384938976 cites W2055971447 @default.
- W4384938976 cites W2072644682 @default.
- W4384938976 cites W2074252493 @default.
- W4384938976 cites W2088764206 @default.
- W4384938976 cites W2100713606 @default.
- W4384938976 cites W2101617459 @default.
- W4384938976 cites W2107705149 @default.
- W4384938976 cites W2113532798 @default.
- W4384938976 cites W2134742719 @default.
- W4384938976 cites W2164659462 @default.
- W4384938976 cites W2164829352 @default.
- W4384938976 cites W2166903664 @default.
- W4384938976 cites W2273228306 @default.
- W4384938976 cites W2404622021 @default.
- W4384938976 cites W2519344407 @default.
- W4384938976 cites W2530677205 @default.
- W4384938976 cites W2599634799 @default.
- W4384938976 cites W2792236328 @default.
- W4384938976 cites W3036117037 @default.
- W4384938976 cites W3055009501 @default.
- W4384938976 cites W3156271189 @default.
- W4384938976 cites W3181088086 @default.
- W4384938976 cites W3182194113 @default.
- W4384938976 cites W3196985151 @default.
- W4384938976 cites W4298151906 @default.
- W4384938976 cites W4307454126 @default.
- W4384938976 cites W4321100309 @default.
- W4384938976 cites W4367312675 @default.
- W4384938976 cites W4376138516 @default.
- W4384938976 cites W4376226397 @default.
- W4384938976 cites W4382451192 @default.
- W4384938976 doi "https://doi.org/10.1016/j.ijbiomac.2023.125915" @default.
- W4384938976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37481175" @default.
- W4384938976 hasPublicationYear "2023" @default.
- W4384938976 type Work @default.
- W4384938976 citedByCount "2" @default.
- W4384938976 countsByYear W43849389762022 @default.
- W4384938976 countsByYear W43849389762023 @default.
- W4384938976 crossrefType "journal-article" @default.
- W4384938976 hasAuthorship W4384938976A5066971089 @default.
- W4384938976 hasBestOaLocation W43849389761 @default.
- W4384938976 hasConcept C12554922 @default.
- W4384938976 hasConcept C155164980 @default.
- W4384938976 hasConcept C159467904 @default.
- W4384938976 hasConcept C160145004 @default.
- W4384938976 hasConcept C170493617 @default.
- W4384938976 hasConcept C178790620 @default.
- W4384938976 hasConcept C180577832 @default.
- W4384938976 hasConcept C181199279 @default.
- W4384938976 hasConcept C185592680 @default.
- W4384938976 hasConcept C194544171 @default.
- W4384938976 hasConcept C204389451 @default.
- W4384938976 hasConcept C2781216036 @default.
- W4384938976 hasConcept C55493867 @default.
- W4384938976 hasConcept C59061564 @default.
- W4384938976 hasConcept C86803240 @default.
- W4384938976 hasConceptScore W4384938976C12554922 @default.
- W4384938976 hasConceptScore W4384938976C155164980 @default.
- W4384938976 hasConceptScore W4384938976C159467904 @default.
- W4384938976 hasConceptScore W4384938976C160145004 @default.
- W4384938976 hasConceptScore W4384938976C170493617 @default.
- W4384938976 hasConceptScore W4384938976C178790620 @default.
- W4384938976 hasConceptScore W4384938976C180577832 @default.
- W4384938976 hasConceptScore W4384938976C181199279 @default.
- W4384938976 hasConceptScore W4384938976C185592680 @default.
- W4384938976 hasConceptScore W4384938976C194544171 @default.
- W4384938976 hasConceptScore W4384938976C204389451 @default.
- W4384938976 hasConceptScore W4384938976C2781216036 @default.
- W4384938976 hasConceptScore W4384938976C55493867 @default.
- W4384938976 hasConceptScore W4384938976C59061564 @default.
- W4384938976 hasConceptScore W4384938976C86803240 @default.
- W4384938976 hasFunder F4320306168 @default.
- W4384938976 hasFunder F4320306230 @default.
- W4384938976 hasFunder F4320337357 @default.
- W4384938976 hasLocation W43849389761 @default.
- W4384938976 hasLocation W43849389762 @default.
- W4384938976 hasOpenAccess W4384938976 @default.
- W4384938976 hasPrimaryLocation W43849389761 @default.
- W4384938976 hasRelatedWork W1790023182 @default.
- W4384938976 hasRelatedWork W1973796039 @default.
- W4384938976 hasRelatedWork W1975761826 @default.