Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384942582> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4384942582 abstract "The cutaneous vasculature is an accessible tissue that can be used to assess microvascular function in humans. Intradermal microdialysis is a minimally invasive technique used to investigate mechanisms of vascular smooth muscle and endothelial function in the cutaneous circulation. This technique allows for the pharmacological dissection of the pathophysiology of microvascular endothelial dysfunction as indexed by decreased nitric oxide-mediated vasodilation, an indicator of cardiovascular disease development risk. In this technique, a microdialysis probe is placed in the dermal layer of the skin, and a local heating unit with a laser Doppler flowmetry probe is placed over the probe to measure the red blood cell flux. The local skin temperature is clamped or stimulated with direct heat application, and pharmacological agents are perfused through the probe to stimulate or inhibit intracellular signaling pathways in order to induce vasodilation or vasoconstriction or to interrogate mechanisms of interest (co-factors, antioxidants, etc.). The cutaneous vascular conductance is quantified, and mechanisms of endothelial dysfunction in disease states can be delineated." @default.
- W4384942582 created "2023-07-22" @default.
- W4384942582 creator A5005754752 @default.
- W4384942582 creator A5020687550 @default.
- W4384942582 creator A5078780937 @default.
- W4384942582 creator A5081999319 @default.
- W4384942582 date "2023-07-21" @default.
- W4384942582 modified "2023-09-27" @default.
- W4384942582 title "Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans" @default.
- W4384942582 doi "https://doi.org/10.3791/65579" @default.
- W4384942582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37548450" @default.
- W4384942582 hasPublicationYear "2023" @default.
- W4384942582 type Work @default.
- W4384942582 citedByCount "0" @default.
- W4384942582 crossrefType "journal-article" @default.
- W4384942582 hasAuthorship W4384942582A5005754752 @default.
- W4384942582 hasAuthorship W4384942582A5020687550 @default.
- W4384942582 hasAuthorship W4384942582A5078780937 @default.
- W4384942582 hasAuthorship W4384942582A5081999319 @default.
- W4384942582 hasConcept C10162356 @default.
- W4384942582 hasConcept C120770815 @default.
- W4384942582 hasConcept C126322002 @default.
- W4384942582 hasConcept C12722491 @default.
- W4384942582 hasConcept C142724271 @default.
- W4384942582 hasConcept C158846371 @default.
- W4384942582 hasConcept C164705383 @default.
- W4384942582 hasConcept C2776992346 @default.
- W4384942582 hasConcept C2777691872 @default.
- W4384942582 hasConcept C2779961880 @default.
- W4384942582 hasConcept C2780972559 @default.
- W4384942582 hasConcept C50156730 @default.
- W4384942582 hasConcept C519581460 @default.
- W4384942582 hasConcept C52305850 @default.
- W4384942582 hasConcept C529278444 @default.
- W4384942582 hasConcept C71924100 @default.
- W4384942582 hasConceptScore W4384942582C10162356 @default.
- W4384942582 hasConceptScore W4384942582C120770815 @default.
- W4384942582 hasConceptScore W4384942582C126322002 @default.
- W4384942582 hasConceptScore W4384942582C12722491 @default.
- W4384942582 hasConceptScore W4384942582C142724271 @default.
- W4384942582 hasConceptScore W4384942582C158846371 @default.
- W4384942582 hasConceptScore W4384942582C164705383 @default.
- W4384942582 hasConceptScore W4384942582C2776992346 @default.
- W4384942582 hasConceptScore W4384942582C2777691872 @default.
- W4384942582 hasConceptScore W4384942582C2779961880 @default.
- W4384942582 hasConceptScore W4384942582C2780972559 @default.
- W4384942582 hasConceptScore W4384942582C50156730 @default.
- W4384942582 hasConceptScore W4384942582C519581460 @default.
- W4384942582 hasConceptScore W4384942582C52305850 @default.
- W4384942582 hasConceptScore W4384942582C529278444 @default.
- W4384942582 hasConceptScore W4384942582C71924100 @default.
- W4384942582 hasIssue "197" @default.
- W4384942582 hasLocation W43849425821 @default.
- W4384942582 hasLocation W43849425822 @default.
- W4384942582 hasOpenAccess W4384942582 @default.
- W4384942582 hasPrimaryLocation W43849425821 @default.
- W4384942582 hasRelatedWork W1969234527 @default.
- W4384942582 hasRelatedWork W2044700993 @default.
- W4384942582 hasRelatedWork W2088315142 @default.
- W4384942582 hasRelatedWork W2114215552 @default.
- W4384942582 hasRelatedWork W2116999983 @default.
- W4384942582 hasRelatedWork W216651141 @default.
- W4384942582 hasRelatedWork W2412212772 @default.
- W4384942582 hasRelatedWork W2466412077 @default.
- W4384942582 hasRelatedWork W4384942613 @default.
- W4384942582 hasRelatedWork W938464384 @default.
- W4384942582 isParatext "false" @default.
- W4384942582 isRetracted "false" @default.
- W4384942582 workType "article" @default.