FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384997675> ?p ?o ?g. }

• W4384997675 endingPage "560" @default.
• W4384997675 startingPage "551" @default.
• W4384997675 abstract "Interferon (INF) is a kind of multifunctional and highly active protein-like cytokines produced by animal cells after stimulation, which exerts the broad-spectrum antiviral, anti-tumor, and immunomodulatory effects. Preparing the nanoparticles (NPs) loaded drug can improve the stability of protein polypeptides in vivo , prolong the biological half-life period, and improve the bioavailability. In this research, recombinant human interferon (RHUINF) α -2b NPs were prepared to explore their therapeutic effect on human papillomavirus (HPV) infection model. Firstly, the RHUINF α -2b poly (lactic acid-glycolic acid) copolymer (PLGA) of composite bioactive glass was prepared by electrostatic spray technology. The in vitro quality, stability, and pharmacokinetic characteristics in vivo of the NPs were measured. Then, a mouse model infected with HPV16 pseudovirus infection (NC group) was prepared. Next, they were treated by painting imiquimod (IMQ) (IMQ group), intramuscularly injecting the RHUINF α -2b (Intron A), intramuscularly injecting the RHUINF α -2b-Plga NP suspension (Intra/PLGA), and intramuscularly injecting the RHUINF α -2B-bioactive glass-PLGA NP suspension (Intron A/BAG/PLGA), respectively. In addition, the differences in serum inflammatory cytokines, vaginal biofluorescence activity (VBA), HPV load, and LMX 1A expressions in cervical exhumation cells (CECs) were analyzed. The average particle sizes (PSs) of Intron A/PLGA and Intron A/BAG/PLGA NPs were 352.3 nm and 385.1 nm, respectively, and no great differences were observed in encapsulation rate (ER), drug loading (DL), and in vivo release (IVR). The maximum peak times (MPTs) of Intron A, Intron A/PLGA, and Intron A/BAG/PLGA were 1.3 h, 6.2 h, and 6.5 h, respectively, and their maintenance durations were 5.5 h, 120.7 h, and 245.6 h, respectively. Based on the NC group, IFN- γ , IL-2, and TNF- α in the IMQ group, Intron A group, Intron A/PLGA group, Intron A/PLGA group, and Intron A/BAG/PLGA group were decreased, VBA and HPV load were decreased, and mRNA of LMX 1A in ECEs was increased ( p < 0.05). Based on the Intron A group, the Intron A/PLGA and Intron A/BAG/PLGA groups exhibited decreased serum inflammatory factors (IFFs), VBA, HPV load, and LMX 1A mRNA in the CECs were increased ( p < 0.05). By taking the Intron A/PLGA group as reference, the Intron A/BAG/PLGA group showed greatly reduced serum IFFs, VBA, HPV load, and LMX 1A mRNA expression in CECs ( p <0.05). Preparing RHUINF α -2b NPs could prolong the half-life period of RHUINF α -2b in vivo , reduce the inflammatory response and load of HPV-DNA in HPV infection models, and upregulate LMX 1A in CECs. In addition, RHUINF α -2b NPs could improve the therapeutic effect of RHUINF α -2b." @default.
• W4384997675 created "2023-07-22" @default.
• W4384997675 creator A5004739135 @default.
• W4384997675 creator A5022585660 @default.
• W4384997675 creator A5022928503 @default.
• W4384997675 creator A5025400050 @default.
• W4384997675 creator A5033357672 @default.
• W4384997675 creator A5033510051 @default.
• W4384997675 creator A5044022343 @default.
• W4384997675 creator A5062954824 @default.
• W4384997675 date "2023-04-01" @default.
• W4384997675 modified "2023-09-26" @default.
• W4384997675 title "Recombinant Human Interferon <i>α</i>-2b Nanoparticles in the Treatment of Human Papillomavirus Infection Model and Detection of LMX 1A Expression in Cervical Exhumation Cells" @default.
• W4384997675 cites W2125678197 @default.
• W4384997675 cites W2750818602 @default.
• W4384997675 cites W2800314494 @default.
• W4384997675 cites W2810249533 @default.
• W4384997675 cites W2906944698 @default.
• W4384997675 cites W2921279634 @default.
• W4384997675 cites W2946288898 @default.
• W4384997675 cites W2976062484 @default.
• W4384997675 cites W3003249044 @default.
• W4384997675 cites W3003440392 @default.
• W4384997675 cites W3035559751 @default.
• W4384997675 cites W3093703153 @default.
• W4384997675 cites W3126855512 @default.
• W4384997675 cites W3167370391 @default.
• W4384997675 cites W3167988042 @default.
• W4384997675 cites W3187380191 @default.
• W4384997675 cites W3207812428 @default.
• W4384997675 cites W3209481766 @default.
• W4384997675 cites W3215747935 @default.
• W4384997675 cites W4207057286 @default.
• W4384997675 cites W4221025537 @default.
• W4384997675 cites W4226028098 @default.
• W4384997675 cites W4226495883 @default.
• W4384997675 cites W4229332549 @default.
• W4384997675 cites W4229445329 @default.
• W4384997675 cites W4281393332 @default.
• W4384997675 cites W4288043657 @default.
• W4384997675 cites W4319983618 @default.
• W4384997675 doi "https://doi.org/10.1166/sam.2023.4463" @default.
• W4384997675 hasPublicationYear "2023" @default.
• W4384997675 type Work @default.
• W4384997675 citedByCount "0" @default.
• W4384997675 crossrefType "journal-article" @default.
• W4384997675 hasAuthorship W4384997675A5004739135 @default.
• W4384997675 hasAuthorship W4384997675A5022585660 @default.
• W4384997675 hasAuthorship W4384997675A5022928503 @default.
• W4384997675 hasAuthorship W4384997675A5025400050 @default.
• W4384997675 hasAuthorship W4384997675A5033357672 @default.
• W4384997675 hasAuthorship W4384997675A5033510051 @default.
• W4384997675 hasAuthorship W4384997675A5044022343 @default.
• W4384997675 hasAuthorship W4384997675A5062954824 @default.
• W4384997675 hasConcept C104317684 @default.
• W4384997675 hasConcept C150903083 @default.
• W4384997675 hasConcept C153911025 @default.
• W4384997675 hasConcept C155672457 @default.
• W4384997675 hasConcept C159047783 @default.
• W4384997675 hasConcept C171250308 @default.
• W4384997675 hasConcept C17991360 @default.
• W4384997675 hasConcept C181389837 @default.
• W4384997675 hasConcept C192562407 @default.
• W4384997675 hasConcept C203014093 @default.
• W4384997675 hasConcept C207001950 @default.
• W4384997675 hasConcept C2776178377 @default.
• W4384997675 hasConcept C2780165375 @default.
• W4384997675 hasConcept C40767141 @default.
• W4384997675 hasConcept C55493867 @default.
• W4384997675 hasConcept C71924100 @default.
• W4384997675 hasConcept C86803240 @default.
• W4384997675 hasConcept C94671646 @default.
• W4384997675 hasConcept C98274493 @default.
• W4384997675 hasConceptScore W4384997675C104317684 @default.
• W4384997675 hasConceptScore W4384997675C150903083 @default.
• W4384997675 hasConceptScore W4384997675C153911025 @default.
• W4384997675 hasConceptScore W4384997675C155672457 @default.
• W4384997675 hasConceptScore W4384997675C159047783 @default.
• W4384997675 hasConceptScore W4384997675C171250308 @default.
• W4384997675 hasConceptScore W4384997675C17991360 @default.
• W4384997675 hasConceptScore W4384997675C181389837 @default.
• W4384997675 hasConceptScore W4384997675C192562407 @default.
• W4384997675 hasConceptScore W4384997675C203014093 @default.
• W4384997675 hasConceptScore W4384997675C207001950 @default.
• W4384997675 hasConceptScore W4384997675C2776178377 @default.
• W4384997675 hasConceptScore W4384997675C2780165375 @default.
• W4384997675 hasConceptScore W4384997675C40767141 @default.
• W4384997675 hasConceptScore W4384997675C55493867 @default.
• W4384997675 hasConceptScore W4384997675C71924100 @default.
• W4384997675 hasConceptScore W4384997675C86803240 @default.
• W4384997675 hasConceptScore W4384997675C94671646 @default.
• W4384997675 hasConceptScore W4384997675C98274493 @default.
• W4384997675 hasIssue "4" @default.
• W4384997675 hasLocation W43849976751 @default.
• W4384997675 hasOpenAccess W4384997675 @default.
• W4384997675 hasPrimaryLocation W43849976751 @default.
• W4384997675 hasRelatedWork W1965016416 @default.
• W4384997675 hasRelatedWork W2001976307 @default.

• next