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- W4385063896 abstract "Bladder cancer is a common tumour worldwide and exhibits a poor prognosis. Fibronectin leucine rich transmembrane protein 2 (FLRT2) is associated with the regulation of multiple tumours; however, its function in human bladder cancer remain unclear. Herein, we found that FLRT2 level was reduced in human bladder cancer and that higher FLRT2 level predicted lower survival rate. FLRT2 overexpression inhibited, while FLRT2 silence facilitated tumour cell growth, migration and invasion. Mechanistic studies revealed that FLRT2 elevated acyl-CoA synthetase long-chain family member 4 (ACSL4) expression, increased lipid peroxidation and subsequently facilitated ferroptosis of human bladder cancer cells. In summary, we demonstrate that FLRT2 elevates ACSL4 expression to facilitate lipid peroxidation and subsequently triggers ferroptosis, thereby inhibiting the malignant phenotype of human bladder cancer cells. Overall, we identify FLRT2 as a tumour suppressor gene." @default.
- W4385063896 created "2023-07-23" @default.
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- W4385063896 date "2023-07-21" @default.
- W4385063896 modified "2023-10-17" @default.
- W4385063896 title "<scp>FLRT2</scp> suppresses bladder cancer progression through inducing ferroptosis" @default.
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- W4385063896 doi "https://doi.org/10.1111/jcmm.17855" @default.
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