Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385064465> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4385064465 abstract "Abstract Background To investigate the presence of different isotypes of anti-carbamylated protein (CarP) antibodies in systemic sclerosis (SSc) patients and its association with skin involvement. Methods Sera of 194 SSc patients from the Leiden CCISS cohort, fulfilling ACR/EULAR 2013 criteria and a clinical diagnosis of SSc, 83 patients with other connective tissue diseases/Raynaud’s Phenomenon, 24 rheumatoid arthritis patients and 98 age and sex-matched healthy controls were tested for the presence of anti-CarP IgG, IgA and IgM, determined by ELISA. Clinical characteristics, that were evaluated in SSc patients, included age, anti-topoisomerase antibodies (ATA), anti-centromere antibodies (ACA) and modified Rodnan Skin Score (mRSS). Results The SSc patients were 55 (SD:13) years and 155 (80%) were female. Forty-four (23%) patients tested positive for ATA, and 80 (42%) ACA. The median mRSS was 2 (range: 0; 47). Prevalence of anti-CarP IgG was higher in SSc patients than in healthy controls (8% vs 3%, p = 0.007. Prevalence of anti-CarP IgA and IgM and levels of anti-CarP isotypes were comparable between SSc patients and healthy controls. Fifteen (8%) SSc patients tested positive for anti-CarP IgG, 16 (8%) for anti-CarP IgA, and 36 (19%) for anti-CarP IgM. There were no significant correlations between age and levels of anti-CarP isotypes. No correlation between anti-CarP IgG levels and mRSS was found ( r = 0.141, p = 0.049), nor for anti-CarP IgM and IgA levels. Anti-CarP IgA levels were higher in ATA compared to ACA positive SSc patients (ATA: 616 aU/ml [359; 1103]; ACA: 424 aU/ml [300; 673], p = 0.015). Conclusion SSc patients can test positive for Anti-CarP IgG, IgA and IgM. We do not observe a relevant clinical association between anti-CarP antibody response and skin involvement in SSc." @default.
- W4385064465 created "2023-07-23" @default.
- W4385064465 creator A5002498432 @default.
- W4385064465 creator A5006079113 @default.
- W4385064465 creator A5017389646 @default.
- W4385064465 creator A5023177378 @default.
- W4385064465 creator A5034627403 @default.
- W4385064465 creator A5040080747 @default.
- W4385064465 creator A5049437946 @default.
- W4385064465 creator A5052842332 @default.
- W4385064465 creator A5091791363 @default.
- W4385064465 date "2023-07-21" @default.
- W4385064465 modified "2023-10-05" @default.
- W4385064465 title "Anti-carbamylated protein antibodies in systemic sclerosis" @default.
- W4385064465 cites W1988241269 @default.
- W4385064465 cites W2037609099 @default.
- W4385064465 cites W2038274426 @default.
- W4385064465 cites W2059353973 @default.
- W4385064465 cites W2121599003 @default.
- W4385064465 cites W2130052733 @default.
- W4385064465 cites W2164096595 @default.
- W4385064465 cites W2174760408 @default.
- W4385064465 cites W2338991382 @default.
- W4385064465 cites W2394768513 @default.
- W4385064465 cites W2401341816 @default.
- W4385064465 cites W2552737670 @default.
- W4385064465 cites W2907082769 @default.
- W4385064465 cites W4211001791 @default.
- W4385064465 doi "https://doi.org/10.1186/s13075-023-03099-3" @default.
- W4385064465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37480150" @default.
- W4385064465 hasPublicationYear "2023" @default.
- W4385064465 type Work @default.
- W4385064465 citedByCount "0" @default.
- W4385064465 crossrefType "journal-article" @default.
- W4385064465 hasAuthorship W4385064465A5002498432 @default.
- W4385064465 hasAuthorship W4385064465A5006079113 @default.
- W4385064465 hasAuthorship W4385064465A5017389646 @default.
- W4385064465 hasAuthorship W4385064465A5023177378 @default.
- W4385064465 hasAuthorship W4385064465A5034627403 @default.
- W4385064465 hasAuthorship W4385064465A5040080747 @default.
- W4385064465 hasAuthorship W4385064465A5049437946 @default.
- W4385064465 hasAuthorship W4385064465A5052842332 @default.
- W4385064465 hasAuthorship W4385064465A5091791363 @default.
- W4385064465 hasBestOaLocation W43850644651 @default.
- W4385064465 hasConcept C126322002 @default.
- W4385064465 hasConcept C159654299 @default.
- W4385064465 hasConcept C163764329 @default.
- W4385064465 hasConcept C180032290 @default.
- W4385064465 hasConcept C198451711 @default.
- W4385064465 hasConcept C203014093 @default.
- W4385064465 hasConcept C2776670291 @default.
- W4385064465 hasConcept C2777575956 @default.
- W4385064465 hasConcept C2778891732 @default.
- W4385064465 hasConcept C2779075594 @default.
- W4385064465 hasConcept C2779967694 @default.
- W4385064465 hasConcept C2909208804 @default.
- W4385064465 hasConcept C505870484 @default.
- W4385064465 hasConcept C71924100 @default.
- W4385064465 hasConcept C72563966 @default.
- W4385064465 hasConcept C86803240 @default.
- W4385064465 hasConcept C90924648 @default.
- W4385064465 hasConceptScore W4385064465C126322002 @default.
- W4385064465 hasConceptScore W4385064465C159654299 @default.
- W4385064465 hasConceptScore W4385064465C163764329 @default.
- W4385064465 hasConceptScore W4385064465C180032290 @default.
- W4385064465 hasConceptScore W4385064465C198451711 @default.
- W4385064465 hasConceptScore W4385064465C203014093 @default.
- W4385064465 hasConceptScore W4385064465C2776670291 @default.
- W4385064465 hasConceptScore W4385064465C2777575956 @default.
- W4385064465 hasConceptScore W4385064465C2778891732 @default.
- W4385064465 hasConceptScore W4385064465C2779075594 @default.
- W4385064465 hasConceptScore W4385064465C2779967694 @default.
- W4385064465 hasConceptScore W4385064465C2909208804 @default.
- W4385064465 hasConceptScore W4385064465C505870484 @default.
- W4385064465 hasConceptScore W4385064465C71924100 @default.
- W4385064465 hasConceptScore W4385064465C72563966 @default.
- W4385064465 hasConceptScore W4385064465C86803240 @default.
- W4385064465 hasConceptScore W4385064465C90924648 @default.
- W4385064465 hasIssue "1" @default.
- W4385064465 hasLocation W43850644651 @default.
- W4385064465 hasLocation W43850644652 @default.
- W4385064465 hasLocation W43850644653 @default.
- W4385064465 hasOpenAccess W4385064465 @default.
- W4385064465 hasPrimaryLocation W43850644651 @default.
- W4385064465 hasRelatedWork W182203678 @default.
- W4385064465 hasRelatedWork W1973542564 @default.
- W4385064465 hasRelatedWork W1999301958 @default.
- W4385064465 hasRelatedWork W2037707055 @default.
- W4385064465 hasRelatedWork W2064502443 @default.
- W4385064465 hasRelatedWork W2101875571 @default.
- W4385064465 hasRelatedWork W2406420051 @default.
- W4385064465 hasRelatedWork W2425255793 @default.
- W4385064465 hasRelatedWork W58587331 @default.
- W4385064465 hasRelatedWork W606865750 @default.
- W4385064465 hasVolume "25" @default.
- W4385064465 isParatext "false" @default.
- W4385064465 isRetracted "false" @default.
- W4385064465 workType "article" @default.