Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385064543> ?p ?o ?g. }
- W4385064543 endingPage "e0288788" @default.
- W4385064543 startingPage "e0288788" @default.
- W4385064543 abstract "Low fertility and adverse pregnancy outcomes are commonly observed in women with chronic kidney disease (CKD). However, a causal relationship between low fertility and adverse pregnancy outcomes with CKD remains unclear. Besides, whether mild kidney dysfunction can affect fertility and pregnancy still needs exploration. Hence, this study aimed to investigate the causal effect of kidney damage on fertility and pregnancy using Mendelian randomization (MR).We first used two-sample MR to examine the effects of kidney damage on fertility and pregnancy. Next, we introduced the Bayesian model averaging MR analysis to detect major causal relationships and render the results robust. The genetic instruments and outcome data were derived from various large genome-wide association studies.Adverse pregnancy outcomes: Our analyses supported a suggestive causal effect of CKD and estimated glomerular filtration rate (eGFR) rapid on stillbirth, with CKD having an odds ratio (OR) of 1.020 [95% confidence interval (CI) 1.002 to 1.038] and eGFR rapid having an OR of 1.026 (95% CI 1.004-1.048). We also discovered a suggestive causal effect of eGFR on spontaneous abortion, with an OR of 2.63 (95% CI 1.269 to 5.450). Moreover, increased urinary albumin-to-creatinine ratio (UACR) was regarded as a potential risk factor for pre-eclampsia (OR = 1.936; 95% CI 1.065 to 3.517) and gestational hypertension (OR = 1.700; 95% CI 1.002 to 2.886). Fertility assessment: The results indicated that eGFR and UACR had a suggestive causal relationship with the anti-Müllerian hormone level (eGFR beta: 1.004; UACR beta: 0.405).Our study used MR to demonstrate a suggestive causal relationship between kidney damage and fertility and pregnancy. We reported that mild kidney dysfunction might be a risk factor for reduced fertility and adverse pregnancy outcomes. Dynamic renal detection may help preserve fertility and reduce the risk of pregnancy loss." @default.
- W4385064543 created "2023-07-23" @default.
- W4385064543 creator A5000676767 @default.
- W4385064543 creator A5000737891 @default.
- W4385064543 creator A5055140637 @default.
- W4385064543 creator A5067445946 @default.
- W4385064543 creator A5083483179 @default.
- W4385064543 creator A5085394619 @default.
- W4385064543 date "2023-07-21" @default.
- W4385064543 modified "2023-10-14" @default.
- W4385064543 title "Kidney damage on fertility and pregnancy: A Mendelian randomization" @default.
- W4385064543 cites W1905058580 @default.
- W4385064543 cites W2023856506 @default.
- W4385064543 cites W2045516356 @default.
- W4385064543 cites W2074356064 @default.
- W4385064543 cites W2089025746 @default.
- W4385064543 cites W2102906841 @default.
- W4385064543 cites W2142170372 @default.
- W4385064543 cites W2155965977 @default.
- W4385064543 cites W2171315731 @default.
- W4385064543 cites W2179664655 @default.
- W4385064543 cites W2607031541 @default.
- W4385064543 cites W2608920382 @default.
- W4385064543 cites W2751884637 @default.
- W4385064543 cites W2761960668 @default.
- W4385064543 cites W2768882726 @default.
- W4385064543 cites W2784361996 @default.
- W4385064543 cites W2912902047 @default.
- W4385064543 cites W2942786758 @default.
- W4385064543 cites W2946525881 @default.
- W4385064543 cites W2947278243 @default.
- W4385064543 cites W2951085368 @default.
- W4385064543 cites W2956245605 @default.
- W4385064543 cites W2991007563 @default.
- W4385064543 cites W2998822473 @default.
- W4385064543 cites W3033328624 @default.
- W4385064543 cites W3143449395 @default.
- W4385064543 cites W3176849499 @default.
- W4385064543 cites W3185710912 @default.
- W4385064543 cites W3198130249 @default.
- W4385064543 cites W3203318770 @default.
- W4385064543 cites W3206681920 @default.
- W4385064543 cites W4210446584 @default.
- W4385064543 cites W4253754191 @default.
- W4385064543 cites W4293677687 @default.
- W4385064543 cites W4303968914 @default.
- W4385064543 doi "https://doi.org/10.1371/journal.pone.0288788" @default.
- W4385064543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37478100" @default.
- W4385064543 hasPublicationYear "2023" @default.
- W4385064543 type Work @default.
- W4385064543 citedByCount "0" @default.
- W4385064543 crossrefType "journal-article" @default.
- W4385064543 hasAuthorship W4385064543A5000676767 @default.
- W4385064543 hasAuthorship W4385064543A5000737891 @default.
- W4385064543 hasAuthorship W4385064543A5055140637 @default.
- W4385064543 hasAuthorship W4385064543A5067445946 @default.
- W4385064543 hasAuthorship W4385064543A5083483179 @default.
- W4385064543 hasAuthorship W4385064543A5085394619 @default.
- W4385064543 hasBestOaLocation W43850645431 @default.
- W4385064543 hasConcept C104317684 @default.
- W4385064543 hasConcept C126322002 @default.
- W4385064543 hasConcept C131872663 @default.
- W4385064543 hasConcept C135763542 @default.
- W4385064543 hasConcept C156957248 @default.
- W4385064543 hasConcept C159641895 @default.
- W4385064543 hasConcept C2778653478 @default.
- W4385064543 hasConcept C2779234561 @default.
- W4385064543 hasConcept C2779901538 @default.
- W4385064543 hasConcept C2908647359 @default.
- W4385064543 hasConcept C29456083 @default.
- W4385064543 hasConcept C2993967602 @default.
- W4385064543 hasConcept C518429986 @default.
- W4385064543 hasConcept C54355233 @default.
- W4385064543 hasConcept C71924100 @default.
- W4385064543 hasConcept C86803240 @default.
- W4385064543 hasConcept C99454951 @default.
- W4385064543 hasConceptScore W4385064543C104317684 @default.
- W4385064543 hasConceptScore W4385064543C126322002 @default.
- W4385064543 hasConceptScore W4385064543C131872663 @default.
- W4385064543 hasConceptScore W4385064543C135763542 @default.
- W4385064543 hasConceptScore W4385064543C156957248 @default.
- W4385064543 hasConceptScore W4385064543C159641895 @default.
- W4385064543 hasConceptScore W4385064543C2778653478 @default.
- W4385064543 hasConceptScore W4385064543C2779234561 @default.
- W4385064543 hasConceptScore W4385064543C2779901538 @default.
- W4385064543 hasConceptScore W4385064543C2908647359 @default.
- W4385064543 hasConceptScore W4385064543C29456083 @default.
- W4385064543 hasConceptScore W4385064543C2993967602 @default.
- W4385064543 hasConceptScore W4385064543C518429986 @default.
- W4385064543 hasConceptScore W4385064543C54355233 @default.
- W4385064543 hasConceptScore W4385064543C71924100 @default.
- W4385064543 hasConceptScore W4385064543C86803240 @default.
- W4385064543 hasConceptScore W4385064543C99454951 @default.
- W4385064543 hasFunder F4320321001 @default.
- W4385064543 hasFunder F4320322769 @default.
- W4385064543 hasIssue "7" @default.
- W4385064543 hasLocation W43850645431 @default.
- W4385064543 hasLocation W43850645432 @default.