FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385064567> ?p ?o ?g. }

• W4385064567 endingPage "1445" @default.
• W4385064567 startingPage "1433" @default.
• W4385064567 abstract "Altered endoplasmic reticulum (ER) Ca2+ signaling has been linked with β-cell dysfunction and diabetes development. Store-operated Ca2+ entry replenishes ER Ca2+ through reversible gating of plasma membrane Ca2+ channels by the ER Ca2+ sensor, stromal interaction molecule 1 (STIM1). For characterization of the in vivo impact of STIM1 loss, mice with β-cell-specific STIM1 deletion (STIM1Δβ mice) were generated and challenged with high-fat diet. Interestingly, β-cell dysfunction was observed in female, but not male, mice. Female STIM1Δβ mice displayed reductions in β-cell mass, a concomitant increase in α-cell mass, and reduced expression of markers of β-cell maturity, including MafA and UCN3. Consistent with these findings, STIM1 expression was inversely correlated with HbA1c levels in islets from female, but not male, human organ donors. Mechanistic assays demonstrated that the sexually dimorphic phenotype observed in STIM1Δβ mice was due, in part, to loss of signaling through the noncanonical 17-β estradiol receptor (GPER1), as GPER1 knockdown and inhibition led to a similar loss of expression of β-cell maturity genes in INS-1 cells. Together, these data suggest that STIM1 orchestrates pancreatic β-cell function and identity through GPER1-mediated estradiol signaling.Store-operated Ca2+ entry replenishes endoplasmic reticulum (ER) Ca2+ through reversible gating of plasma membrane Ca2+ channels by the ER Ca2+ sensor, stromal interaction molecule 1 (STIM1). β-Cell-specific deletion of STIM1 results in a sexually dimorphic phenotype, with β-cell dysfunction and loss of identity in female but not male mice. Expression of the noncanonical 17-β estradiol receptor (GPER1) is decreased in islets of female STIM1Δβ mice, and modulation of GPER1 levels leads to alterations in expression of β-cell maturity genes in INS-1 cells." @default.
• W4385064567 created "2023-07-23" @default.
• W4385064567 creator A5030041504 @default.
• W4385064567 creator A5041034720 @default.
• W4385064567 creator A5052976096 @default.
• W4385064567 creator A5063131669 @default.
• W4385064567 creator A5064509382 @default.
• W4385064567 creator A5066166090 @default.
• W4385064567 creator A5066282914 @default.
• W4385064567 creator A5078720265 @default.
• W4385064567 creator A5080415104 @default.
• W4385064567 creator A5084811923 @default.
• W4385064567 date "2023-07-21" @default.
• W4385064567 modified "2023-10-14" @default.
• W4385064567 title "Stromal Interaction Molecule 1 Maintains β Cell Identity and Function in Female Mice through Preservation of G Protein-Coupled Estrogen Receptor 1 Signaling" @default.
• W4385064567 cites W1965657903 @default.
• W4385064567 cites W1971041352 @default.
• W4385064567 cites W1972086601 @default.
• W4385064567 cites W1974091657 @default.
• W4385064567 cites W1986025611 @default.
• W4385064567 cites W1992293805 @default.
• W4385064567 cites W1992611282 @default.
• W4385064567 cites W1996857104 @default.
• W4385064567 cites W2016895073 @default.
• W4385064567 cites W2020708758 @default.
• W4385064567 cites W2025410324 @default.
• W4385064567 cites W2037266625 @default.
• W4385064567 cites W2061574308 @default.
• W4385064567 cites W2067735292 @default.
• W4385064567 cites W2068571139 @default.
• W4385064567 cites W2073311696 @default.
• W4385064567 cites W2075186231 @default.
• W4385064567 cites W2100551231 @default.
• W4385064567 cites W2101586949 @default.
• W4385064567 cites W2101927777 @default.
• W4385064567 cites W2103600331 @default.
• W4385064567 cites W2112573165 @default.
• W4385064567 cites W2114742434 @default.
• W4385064567 cites W2119633928 @default.
• W4385064567 cites W2123432388 @default.
• W4385064567 cites W2138521217 @default.
• W4385064567 cites W2150854253 @default.
• W4385064567 cites W2153134360 @default.
• W4385064567 cites W2153399820 @default.
• W4385064567 cites W2161210718 @default.
• W4385064567 cites W2171294019 @default.
• W4385064567 cites W2380336419 @default.
• W4385064567 cites W2490120783 @default.
• W4385064567 cites W2518040164 @default.
• W4385064567 cites W2567115140 @default.
• W4385064567 cites W2595978963 @default.
• W4385064567 cites W2773617610 @default.
• W4385064567 cites W2796347307 @default.
• W4385064567 cites W2888350833 @default.
• W4385064567 cites W2888394101 @default.
• W4385064567 cites W2900740153 @default.
• W4385064567 cites W2928665623 @default.
• W4385064567 cites W2936057232 @default.
• W4385064567 cites W2943308205 @default.
• W4385064567 cites W2968195232 @default.
• W4385064567 cites W2982288981 @default.
• W4385064567 cites W3003989813 @default.
• W4385064567 cites W3080129453 @default.
• W4385064567 cites W3157214514 @default.
• W4385064567 doi "https://doi.org/10.2337/db22-0988" @default.
• W4385064567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37478155" @default.
• W4385064567 hasPublicationYear "2023" @default.
• W4385064567 type Work @default.
• W4385064567 citedByCount "0" @default.
• W4385064567 crossrefType "journal-article" @default.
• W4385064567 hasAuthorship W4385064567A5030041504 @default.
• W4385064567 hasAuthorship W4385064567A5041034720 @default.
• W4385064567 hasAuthorship W4385064567A5052976096 @default.
• W4385064567 hasAuthorship W4385064567A5063131669 @default.
• W4385064567 hasAuthorship W4385064567A5064509382 @default.
• W4385064567 hasAuthorship W4385064567A5066166090 @default.
• W4385064567 hasAuthorship W4385064567A5066282914 @default.
• W4385064567 hasAuthorship W4385064567A5078720265 @default.
• W4385064567 hasAuthorship W4385064567A5080415104 @default.
• W4385064567 hasAuthorship W4385064567A5084811923 @default.
• W4385064567 hasBestOaLocation W43850645671 @default.
• W4385064567 hasConcept C121608353 @default.
• W4385064567 hasConcept C126322002 @default.
• W4385064567 hasConcept C134018914 @default.
• W4385064567 hasConcept C158617107 @default.
• W4385064567 hasConcept C162740809 @default.
• W4385064567 hasConcept C16930146 @default.
• W4385064567 hasConcept C170493617 @default.
• W4385064567 hasConcept C173396325 @default.
• W4385064567 hasConcept C182704531 @default.
• W4385064567 hasConcept C190283241 @default.
• W4385064567 hasConcept C502942594 @default.
• W4385064567 hasConcept C530470458 @default.
• W4385064567 hasConcept C55493867 @default.
• W4385064567 hasConcept C62478195 @default.
• W4385064567 hasConcept C71924100 @default.
• W4385064567 hasConcept C84606932 @default.
• W4385064567 hasConcept C86803240 @default.

• next