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- W4385065162 abstract "Introduction There is conflicting evidence on the benefits of parathyroidectomy (PTx) in reducing the incidence of cardiovascular disease (CVD) in patients with primary hyperparathyroidism (PHPT). Aim To perform a systematic review and meta-analysis to investigate the impact of PTx in PHPT on cardiovascular outcomes. Methods A systematic review was performed as per PRISMA guidelines. Pre- and post-operative data were expressed as continuous outcomes, reported as mean differences, and expressed with 95% confidence intervals following estimation using the Mantel-Haenszel method. Results In total, there were 16 studies included in the meta-analysis with a combined total of 796 patients. Fourteen studies were prospective, one was retrospective and one was a randomised control trial. This analysis found a significant reduction in SBP post-operatively ( P = 0.003). The difference in DBP was NS ( P = 0.050). Fasting blood glucose levels were also significantly reduced after surgery ( P < 0.0001). Echocardiographic values showed that left ventricular mass index was not significantly reduced ( P = 0.070) and left ventricular ejection fraction was not affected ( P = 0.680). Cholesterol levels were not impacted by surgery. Conclusion This meta-analysis shows that PTx likely improves SBP and blood glucose levels in patients with PHPT. It is unclear if this in turn has any impact on long-term outcomes." @default.
- W4385065162 created "2023-07-23" @default.
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- W4385065162 date "2023-07-20" @default.
- W4385065162 modified "2023-09-26" @default.
- W4385065162 title "Cardiovascular parameters following parathyroidectomy in primary hyperparathyroidism: a systematic review and meta-analysis" @default.
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- W4385065162 doi "https://doi.org/10.1097/xce.0000000000000288" @default.
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