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• W4385065900 abstract "Objective Although previous studies have reported an association between thyroid function and anti-Müllerian hormone (AMH) levels, which is considered a reliable marker of ovarian reserve, the causal relationship between them remains uncertain. This study aims to investigate whether thyrotropin (TSH), free thyroxine (fT4), hypo- and hyperthyroidism are causally linked to AMH levels. Methods We obtained summary statistics from three sources: the ThyroidOmics Consortium (N = 54,288), HUNT + MGI + ThyroidOmics meta-analysis (N = 119,715), and the most recent AMH genome-wide association meta-analysis (N = 7,049). Two-sample MR analyses were conducted using instrumental variables representing TSH and fT4 levels within the normal range. Additionally, we conducted secondary analyses to explore the effects of hypo- and hyperthyroidism. Subgroup analyses for TSH were also performed. Results MR analyses did not show any causality relationship between thyroid function and AMH levels, using normal range TSH, normal range fT4, subclinical hypothyroidism, subclinical hyperthyroidism and overt hypothyroidism as exposure, respectively. In addition, neither full range TSH nor TSH with individuals &lt;50 years old was causally associated with AMH levels. MR sensitivity analyses guaranteed the robustness of all MR results, except for the association between fT4 and AMH in the no- DIO1 + DIO2 group. Conclusion Our findings suggest that there was no causal association between genetically predicted thyroid function and AMH levels in the European population." @default.
• W4385065900 created "2023-07-23" @default.
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• W4385065900 date "2023-07-20" @default.
• W4385065900 modified "2023-10-18" @default.
• W4385065900 title "Mendelian randomization study of thyroid function and anti-Müllerian hormone levels" @default.
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• W4385065900 doi "https://doi.org/10.3389/fendo.2023.1188284" @default.
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