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• W4385069615 endingPage "2048" @default.
• W4385069615 startingPage "2048" @default.
• W4385069615 abstract "We have employed mathematical modeling techniques to construct a comprehensive framework for elucidating the intricate response mechanisms of the immune system, facilitating a deeper understanding of B-cell clonal deletion and somatic hypermutation. Our improved model introduces innovative mechanisms that shed light on positive and negative selection processes during T-cell and B-cell development. Notably, clonal deletion is attributed to the attenuated immune stimulation exerted by self-antigens with high binding affinities, rendering them less effective in eliciting subsequent B-cell maturation and differentiation. Secondly, our refined model places particular emphasis on the crucial role played by somatic hypermutation in modulating the immune system’s functionality. Through extensive investigation, we have determined that somatic hypermutation not only expedites the production of highly specific antibodies pivotal in combating microbial infections but also serves as a regulatory mechanism to dampen autoimmunity and enhance self-tolerance within the organism. Lastly, our model advances the understanding of the implications of antibody in vivo evolution in the overall process of organismal aging. With the progression of time, the age-associated amplification of autoimmune activity becomes apparent. While somatic hypermutation effectively delays this process, mitigating the levels of autoimmune response, it falls short of reversing this trajectory entirely. In conclusion, our advanced mathematical model offers a comprehensive and scholarly approach to comprehend the intricacies of the immune system. By encompassing novel mechanisms for selection, emphasizing the functional role of somatic hypermutation, and illuminating the consequences of in vivo antibody evolution, our model expands the current understanding of immune responses and their implications in aging." @default.
• W4385069615 created "2023-07-23" @default.
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• W4385069615 date "2023-07-20" @default.
• W4385069615 modified "2023-10-18" @default.
• W4385069615 title "Antibody Dynamics Simulation—A Mathematical Exploration of Clonal Deletion and Somatic Hypermutation" @default.
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• W4385069615 doi "https://doi.org/10.3390/biomedicines11072048" @default.
• W4385069615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37509687" @default.
• W4385069615 hasPublicationYear "2023" @default.
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