Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385070121> ?p ?o ?g. }
- W4385070121 abstract "Oxidative stress, inflammatory response, and gut-liver axis dysbiosis have been suggested as the primarily involved in the pathogenesis of alcoholic liver injury. Previous research established that yeast extract (YE) has antioxidant, immune-boosting or microbiota-regulating properties. However, there is currently lack of information regarding the efficacy of YE on alcoholic liver injury. This study seeks to obtain data that will help to address this research gap using a Wistar male rat experimental model. Histologic and biochemical analysis results showed that the groups treated with both low-dose yeast extract (YEL) and high-dose yeast extract (YEH) had lower degrees of alcohol-induced liver injury. The abundance of Peptococcus and Ruminococcus reduced in the low-dose yeast extract (YEL) group, while that of Peptococcus, Romboutsia, Parasutterella, and Faecalibaculum reduced in the high-dose (YEH) group. Furthermore, Spearman analysis showed that the gut microbes were significantly associated with several liver-related indicators. For the analysis of differential metabolites and enriched pathways in the YEL group, the abundance of lysophosphatidylcholine (16:0/0:0) significantly increased, and then the levels of histamine, adenosine and 5' -adenine nucleotide were remarkedly elevated in the YEH group. These findings suggest that both high and low doses of YE can have different protective effects on liver injury in alcoholic liver disease (ALD) rats, in addition to improving gut microbiota disorder. Besides, high-dose YE has been found to be more effective than low-dose YE in metabolic regulation, as well as in dealing with oxidative stress and inflammatory responses." @default.
- W4385070121 created "2023-07-23" @default.
- W4385070121 creator A5001014826 @default.
- W4385070121 creator A5004382244 @default.
- W4385070121 creator A5009783386 @default.
- W4385070121 creator A5026853706 @default.
- W4385070121 creator A5029439092 @default.
- W4385070121 creator A5036640081 @default.
- W4385070121 creator A5037641311 @default.
- W4385070121 creator A5049057785 @default.
- W4385070121 creator A5054036938 @default.
- W4385070121 creator A5063116224 @default.
- W4385070121 creator A5064633339 @default.
- W4385070121 date "2023-07-20" @default.
- W4385070121 modified "2023-09-26" @default.
- W4385070121 title "Protective effects of yeast extract against alcohol-induced liver injury in rats" @default.
- W4385070121 cites W1490848194 @default.
- W4385070121 cites W1528418710 @default.
- W4385070121 cites W1973692821 @default.
- W4385070121 cites W1991008356 @default.
- W4385070121 cites W2001963220 @default.
- W4385070121 cites W2003272885 @default.
- W4385070121 cites W2005551174 @default.
- W4385070121 cites W2017806914 @default.
- W4385070121 cites W2041916649 @default.
- W4385070121 cites W2047718984 @default.
- W4385070121 cites W2051758543 @default.
- W4385070121 cites W2053542703 @default.
- W4385070121 cites W2055833064 @default.
- W4385070121 cites W2063361409 @default.
- W4385070121 cites W2100787486 @default.
- W4385070121 cites W2104434638 @default.
- W4385070121 cites W2114405620 @default.
- W4385070121 cites W2115358392 @default.
- W4385070121 cites W2124211942 @default.
- W4385070121 cites W2145050940 @default.
- W4385070121 cites W2145758516 @default.
- W4385070121 cites W2159323536 @default.
- W4385070121 cites W2159482845 @default.
- W4385070121 cites W2161771297 @default.
- W4385070121 cites W2211693855 @default.
- W4385070121 cites W2319085923 @default.
- W4385070121 cites W2473481878 @default.
- W4385070121 cites W2497523986 @default.
- W4385070121 cites W2518702192 @default.
- W4385070121 cites W2537092388 @default.
- W4385070121 cites W2580400995 @default.
- W4385070121 cites W2610104725 @default.
- W4385070121 cites W2611920505 @default.
- W4385070121 cites W2622816029 @default.
- W4385070121 cites W2784039673 @default.
- W4385070121 cites W2792068714 @default.
- W4385070121 cites W2795086409 @default.
- W4385070121 cites W2801096943 @default.
- W4385070121 cites W2804782408 @default.
- W4385070121 cites W2810478696 @default.
- W4385070121 cites W2886131169 @default.
- W4385070121 cites W2888258507 @default.
- W4385070121 cites W2889517514 @default.
- W4385070121 cites W2894101807 @default.
- W4385070121 cites W2904629086 @default.
- W4385070121 cites W2940205504 @default.
- W4385070121 cites W2947218622 @default.
- W4385070121 cites W2961821163 @default.
- W4385070121 cites W2970029576 @default.
- W4385070121 cites W2980944208 @default.
- W4385070121 cites W2984068003 @default.
- W4385070121 cites W2990738236 @default.
- W4385070121 cites W3006195412 @default.
- W4385070121 cites W3010697658 @default.
- W4385070121 cites W3019594745 @default.
- W4385070121 cites W3085095837 @default.
- W4385070121 cites W3087358775 @default.
- W4385070121 cites W3087570459 @default.
- W4385070121 cites W3111795541 @default.
- W4385070121 cites W3119280099 @default.
- W4385070121 cites W3159246436 @default.
- W4385070121 cites W3164074301 @default.
- W4385070121 cites W3165992900 @default.
- W4385070121 cites W3171896977 @default.
- W4385070121 cites W3192018253 @default.
- W4385070121 cites W3208911301 @default.
- W4385070121 cites W3216492576 @default.
- W4385070121 cites W4205767889 @default.
- W4385070121 cites W4213361301 @default.
- W4385070121 cites W4220782017 @default.
- W4385070121 cites W4224290020 @default.
- W4385070121 cites W4280514619 @default.
- W4385070121 cites W4281682605 @default.
- W4385070121 cites W4285177374 @default.
- W4385070121 cites W4294216483 @default.
- W4385070121 cites W4303962238 @default.
- W4385070121 cites W4307954084 @default.
- W4385070121 cites W4310877323 @default.
- W4385070121 cites W4318046630 @default.
- W4385070121 doi "https://doi.org/10.3389/fmicb.2023.1217449" @default.
- W4385070121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37547679" @default.
- W4385070121 hasPublicationYear "2023" @default.
- W4385070121 type Work @default.
- W4385070121 citedByCount "0" @default.