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Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385076098> ?p ?o ?g. }

• W4385076098 endingPage "134327" @default.
• W4385076098 startingPage "134327" @default.
• W4385076098 abstract "Mild traumatic brain injury (mTBI) may cause increasing risk of long-term sequelae during brain development among children and adolescents. Recent investigations have declared that salivary microRNAs (miRNAs) in mTBI were reliable diagnostic markers. Herein, a versatile biosensor, namely, self-primer exponential amplified Cas12a tandem (SP-ExACT) reaction for quantifying mTBI-related miRNAs was established by integrating CRISPR-Cas12a with copper(I) 1,2,4-triazolate coordination polymer ([Cu(tz)]) nanosheets. Unlike conventional strand displacement amplification, we designed DNA hairpins with integrated primer and template sequences to generate multiple single-stranded DNA (ssDNA) identical to targets. They could trigger the following rolling circle amplification together and then activate Cas12a to indiscriminately cleave the intact fluorophores-labeled ssDNA that absorbed on [Cu(tz)] nanosheets. The corresponding fluorescence signal would recover for the desorption of cleaved short ssDNA from nanosheets. Owing to the remarkable performance of SP-ExACT-[Cu(tz)] reaction, this biosensor could detect let-7a, miR-30e and miR-21 with a LOD of 11.6, 5.4, 7.4 fM, respectively. This study explored a novel fluorescence biosensor based on [Cu(tz)] nanosheets combined with CRISPR-Cas12a to reduce initial background signal, and combined multiple signal amplification strategies to achieve ultra-sensitive detection. Moreover, multiple mTBI-related miRNAs detection could avoid false positive/negative results, and a universal detection platform was constructed through changing corresponding sequence." @default.
• W4385076098 created "2023-07-23" @default.
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• W4385076098 date "2023-10-01" @default.
• W4385076098 modified "2023-10-17" @default.
• W4385076098 title "Self-primer exponential Cas12a tandem reaction-amplified and [Cu(tz)] nanosheets based neoteric biosensing platform for quantifying multiple mTBI-related miRNAs" @default.
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• W4385076098 doi "https://doi.org/10.1016/j.snb.2023.134327" @default.
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