FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385076484> ?p ?o ?g. }

• W4385076484 endingPage "132111" @default.
• W4385076484 startingPage "132111" @default.
• W4385076484 abstract "The study of membrane morphology transitions is crucial for understanding various biological processes, such as cell division, and intracellular vesicle transport. In this work, we aim to clarify the molecular mechanism underlying the asymmetric solution-induced membrane shape transition in lipid bilayers. Using giant unilamellar vesicles (GUVs) as model membranes, we investigated the interaction of fully hydrated lipid membranes with two distinct sugar solutions—glucose and sucrose. We applied advanced imaging techniques and theoretical analyses to study membrane deformation and its transition pathways. Our experimental observations revealed that asymmetric sugar solutions induce spontaneous curvature in the phospholipid bilayer, resulting in the formation of outward(/inward) budding vesicles over a wide range of parameters. The direction of the curvature can be reversed by exchanging the internal and external solutions, indicating that the sugar-lipid interactions generate a significant positive(/negative) spontaneous curvature. Theoretically, we attempted to determine the parameter range of stable membrane shapes (i.e., phase diagram) using two dimensionless physical parameters—volume-to-area ratio and normalized spontaneous curvature. Obtaining a phase diagram helps identify the transition pathways of GUVs membrane shapes (experimentally, we captured two possible outward budding vesicles and one inward budding vesicle transition pathway). Our findings can be extended to other types of lipid membranes and provide new insights into the deformation of cell-like micron-sized vesicles, such as exosomes and endosomes, which are increasingly used as biomarkers and drug delivery systems. Moreover, lipid vesicles containing anticancer drugs exhibit fewer side effects than non-liposomal anticancer agents and can effectively target solid tumors." @default.
• W4385076484 created "2023-07-23" @default.
• W4385076484 creator A5005567795 @default.
• W4385076484 creator A5013040503 @default.
• W4385076484 creator A5013736647 @default.
• W4385076484 creator A5024167440 @default.
• W4385076484 creator A5039712690 @default.
• W4385076484 creator A5063560186 @default.
• W4385076484 date "2023-10-01" @default.
• W4385076484 modified "2023-09-27" @default.
• W4385076484 title "Membrane inward/outward budding and transition pathway induced by the asymmetric solutions" @default.
• W4385076484 cites W1963573377 @default.
• W4385076484 cites W1966811897 @default.
• W4385076484 cites W1968857212 @default.
• W4385076484 cites W1969783906 @default.
• W4385076484 cites W1995950736 @default.
• W4385076484 cites W1997605263 @default.
• W4385076484 cites W2011844788 @default.
• W4385076484 cites W2024900604 @default.
• W4385076484 cites W2025581386 @default.
• W4385076484 cites W2026726527 @default.
• W4385076484 cites W2027484287 @default.
• W4385076484 cites W2028434936 @default.
• W4385076484 cites W2030762880 @default.
• W4385076484 cites W2040350430 @default.
• W4385076484 cites W2048893204 @default.
• W4385076484 cites W2064585995 @default.
• W4385076484 cites W2071970421 @default.
• W4385076484 cites W2082301112 @default.
• W4385076484 cites W2129141102 @default.
• W4385076484 cites W2149929340 @default.
• W4385076484 cites W2165199923 @default.
• W4385076484 cites W2176347735 @default.
• W4385076484 cites W2274683687 @default.
• W4385076484 cites W2319224459 @default.
• W4385076484 cites W2328951366 @default.
• W4385076484 cites W2510423901 @default.
• W4385076484 cites W2600263059 @default.
• W4385076484 cites W2727050647 @default.
• W4385076484 cites W2790705492 @default.
• W4385076484 cites W2791510587 @default.
• W4385076484 cites W2801571069 @default.
• W4385076484 cites W2884865116 @default.
• W4385076484 cites W2889492337 @default.
• W4385076484 cites W2943338383 @default.
• W4385076484 cites W3005141459 @default.
• W4385076484 cites W3005591085 @default.
• W4385076484 cites W3043079597 @default.
• W4385076484 cites W3047221790 @default.
• W4385076484 cites W3050891994 @default.
• W4385076484 cites W3116681155 @default.
• W4385076484 cites W3134076312 @default.
• W4385076484 cites W3180457059 @default.
• W4385076484 cites W3205054052 @default.
• W4385076484 cites W4200264063 @default.
• W4385076484 cites W4206137149 @default.
• W4385076484 cites W4207077700 @default.
• W4385076484 cites W4283773960 @default.
• W4385076484 cites W4285277834 @default.
• W4385076484 cites W4311734285 @default.
• W4385076484 cites W2988522097 @default.
• W4385076484 doi "https://doi.org/10.1016/j.colsurfa.2023.132111" @default.
• W4385076484 hasPublicationYear "2023" @default.
• W4385076484 type Work @default.
• W4385076484 citedByCount "0" @default.
• W4385076484 crossrefType "journal-article" @default.
• W4385076484 hasAuthorship W4385076484A5005567795 @default.
• W4385076484 hasAuthorship W4385076484A5013040503 @default.
• W4385076484 hasAuthorship W4385076484A5013736647 @default.
• W4385076484 hasAuthorship W4385076484A5024167440 @default.
• W4385076484 hasAuthorship W4385076484A5039712690 @default.
• W4385076484 hasAuthorship W4385076484A5063560186 @default.
• W4385076484 hasConcept C12554922 @default.
• W4385076484 hasConcept C130316041 @default.
• W4385076484 hasConcept C159467904 @default.
• W4385076484 hasConcept C185154212 @default.
• W4385076484 hasConcept C185592680 @default.
• W4385076484 hasConcept C192157962 @default.
• W4385076484 hasConcept C195065555 @default.
• W4385076484 hasConcept C198410946 @default.
• W4385076484 hasConcept C2524010 @default.
• W4385076484 hasConcept C2777278457 @default.
• W4385076484 hasConcept C33923547 @default.
• W4385076484 hasConcept C39944091 @default.
• W4385076484 hasConcept C41625074 @default.
• W4385076484 hasConcept C55493867 @default.
• W4385076484 hasConcept C86803240 @default.
• W4385076484 hasConcept C95444343 @default.
• W4385076484 hasConceptScore W4385076484C12554922 @default.
• W4385076484 hasConceptScore W4385076484C130316041 @default.
• W4385076484 hasConceptScore W4385076484C159467904 @default.
• W4385076484 hasConceptScore W4385076484C185154212 @default.
• W4385076484 hasConceptScore W4385076484C185592680 @default.
• W4385076484 hasConceptScore W4385076484C192157962 @default.
• W4385076484 hasConceptScore W4385076484C195065555 @default.
• W4385076484 hasConceptScore W4385076484C198410946 @default.
• W4385076484 hasConceptScore W4385076484C2524010 @default.
• W4385076484 hasConceptScore W4385076484C2777278457 @default.

• next