FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385077092> ?p ?o ?g. }

• W4385077092 endingPage "618" @default.
• W4385077092 startingPage "611" @default.
• W4385077092 abstract "While allogeneic hematopoietic cell transplant (alloHCT) offers cures for older patients with acute lymphoblastic leukemia (ALL), disease relapse remains a major issue. Whether matched sibling donors (MSD) are still the preferred donor choice compared to younger matched unrelated donors (MUD), in the contemporary era of improved transplant practices, remains unknown. This retrospective cohort registry study queried the Center for International Blood and Marrow Transplant Research database (CIBMTR) data in B-cell ALL patients 50 years or older, undergoing alloHCT from older MSDs (donor age ≥ 50) or younger MUDs (donor age ≤ 35) between 2011 and 2018. The study included common allograft types, conditioning regimens, and graft versus host disease (GVHD) prophylaxis strategies. The primary outcome was relapse risk whereas secondary outcomes included non-relapse mortality (NRM), GVHD, leukemia-free survival (LFS), and overall survival (OS). Among 925 eligible patients in the study cohort, 386 underwent alloHCT with an older MSD (median donor age, 58) whereas 539 received transplant from a younger MUD (median donor age, 25). In multivariable analysis, younger MUDs conferred a significantly decreased risk of relapse (HR 0.68; p=.002) vs older MSDs. The adjusted cumulative incidence of relapse at 5 years was significantly lower with younger MUDs compared to older MSDs (26% vs 37%; p=.001). Younger MUDs were associated with a greater risk of chronic GVHD compared to older MSDs (HR 1.33; 95% CI, 1.10-1.61; p=.003). Compared to older MSDs, younger MUDs conferred an increased NRM (HR 1.38; p=.02) and higher adjusted cumulative incidence of NRM at 5 years (31% vs 22%; p=.006). There were no differences in OS or LFS rates of alloHCT with younger MUDs vs older MSDs (OS: HR 1.09; p=.37; DFS: HR 0.95; p=.57). Younger MUDs could be considered as a possible way to prevent relapse after alloHCT in older adults with ALL. Combining the use of younger MUDs with improved strategies to reduce GVHD is worth further exploration to improve outcomes." @default.
• W4385077092 created "2023-07-23" @default.
• W4385077092 creator A5008575399 @default.
• W4385077092 creator A5017044459 @default.
• W4385077092 creator A5043585238 @default.
• W4385077092 creator A5054372182 @default.
• W4385077092 creator A5058862489 @default.
• W4385077092 creator A5061303658 @default.
• W4385077092 creator A5066224233 @default.
• W4385077092 creator A5069460930 @default.
• W4385077092 creator A5084653699 @default.
• W4385077092 creator A5085360755 @default.
• W4385077092 creator A5088493703 @default.
• W4385077092 creator A5092518641 @default.
• W4385077092 date "2023-10-01" @default.
• W4385077092 modified "2023-10-14" @default.
• W4385077092 title "Younger Matched Unrelated Donors Confer Decreased Relapse Risk Compared to Older Sibling Donors in Older Patients with B Cell Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation" @default.
• W4385077092 cites W1274344746 @default.
• W4385077092 cites W1863755384 @default.
• W4385077092 cites W1967740708 @default.
• W4385077092 cites W1971439170 @default.
• W4385077092 cites W1977380325 @default.
• W4385077092 cites W1995355078 @default.
• W4385077092 cites W2005499564 @default.
• W4385077092 cites W2036055444 @default.
• W4385077092 cites W2052739233 @default.
• W4385077092 cites W2074637790 @default.
• W4385077092 cites W2083825849 @default.
• W4385077092 cites W2117730045 @default.
• W4385077092 cites W2125080520 @default.
• W4385077092 cites W2128491464 @default.
• W4385077092 cites W2141019574 @default.
• W4385077092 cites W2148207894 @default.
• W4385077092 cites W2149858388 @default.
• W4385077092 cites W2166599801 @default.
• W4385077092 cites W2337759633 @default.
• W4385077092 cites W2555027365 @default.
• W4385077092 cites W2611929005 @default.
• W4385077092 cites W2787561869 @default.
• W4385077092 cites W2808607480 @default.
• W4385077092 cites W2910581135 @default.
• W4385077092 cites W2942824536 @default.
• W4385077092 cites W2969949365 @default.
• W4385077092 cites W3035026924 @default.
• W4385077092 cites W3060534398 @default.
• W4385077092 cites W3092166897 @default.
• W4385077092 cites W3093090760 @default.
• W4385077092 cites W3120177348 @default.
• W4385077092 cites W3147838034 @default.
• W4385077092 cites W3198965035 @default.
• W4385077092 cites W4200556274 @default.
• W4385077092 cites W4206233870 @default.
• W4385077092 cites W4224222936 @default.
• W4385077092 cites W4229003210 @default.
• W4385077092 cites W4315631714 @default.
• W4385077092 doi "https://doi.org/10.1016/j.jtct.2023.07.015" @default.
• W4385077092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37481243" @default.
• W4385077092 hasPublicationYear "2023" @default.
• W4385077092 type Work @default.
• W4385077092 citedByCount "1" @default.
• W4385077092 countsByYear W43850770922023 @default.
• W4385077092 crossrefType "journal-article" @default.
• W4385077092 hasAuthorship W4385077092A5008575399 @default.
• W4385077092 hasAuthorship W4385077092A5017044459 @default.
• W4385077092 hasAuthorship W4385077092A5043585238 @default.
• W4385077092 hasAuthorship W4385077092A5054372182 @default.
• W4385077092 hasAuthorship W4385077092A5058862489 @default.
• W4385077092 hasAuthorship W4385077092A5061303658 @default.
• W4385077092 hasAuthorship W4385077092A5066224233 @default.
• W4385077092 hasAuthorship W4385077092A5069460930 @default.
• W4385077092 hasAuthorship W4385077092A5084653699 @default.
• W4385077092 hasAuthorship W4385077092A5085360755 @default.
• W4385077092 hasAuthorship W4385077092A5088493703 @default.
• W4385077092 hasAuthorship W4385077092A5092518641 @default.
• W4385077092 hasConcept C109159458 @default.
• W4385077092 hasConcept C120665830 @default.
• W4385077092 hasConcept C121332964 @default.
• W4385077092 hasConcept C126322002 @default.
• W4385077092 hasConcept C138496976 @default.
• W4385077092 hasConcept C141071460 @default.
• W4385077092 hasConcept C15744967 @default.
• W4385077092 hasConcept C167135981 @default.
• W4385077092 hasConcept C201903717 @default.
• W4385077092 hasConcept C205545832 @default.
• W4385077092 hasConcept C2776194465 @default.
• W4385077092 hasConcept C2777408962 @default.
• W4385077092 hasConcept C2778461978 @default.
• W4385077092 hasConcept C2779972918 @default.
• W4385077092 hasConcept C28328180 @default.
• W4385077092 hasConcept C2911091166 @default.
• W4385077092 hasConcept C2993713153 @default.
• W4385077092 hasConcept C54355233 @default.
• W4385077092 hasConcept C61511704 @default.
• W4385077092 hasConcept C71924100 @default.
• W4385077092 hasConcept C72563966 @default.
• W4385077092 hasConcept C86803240 @default.
• W4385077092 hasConcept C88879693 @default.
• W4385077092 hasConceptScore W4385077092C109159458 @default.

• next