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- W4385146576 abstract "Parkinson's disease (PD) in military personnel engaged in combat operations is likely to develop in their later lives. In order to enhance the quality of lives of PD patients, exploration of novel therapy based on new research strategies is highly warranted. The hallmarks of PD include increased alpha synuclein (ASNC) and phosphorylated tau (p-tau) in the cerebrospinal fluid (CSF) leading to brain pathology. In addition, there are evidences showing increased histaminergic nerve fibers in substantia niagra pars compacta (SNpc), striatum (STr), and caudate putamen (CP) associated with upregulation of histamine H3 receptors and downregulation of H4 receptors in human brain. Previous studies from our group showed that modulation of potent histaminergic H3 receptor inverse agonist BF-2549 or clobenpropit (CLBPT) partial histamine H4 agonist with H3 receptor antagonist induces neuroprotection in PD brain pathology. Recent studies show that PD also enhances amyloid beta peptide (AβP) depositions in brain. Keeping these views in consideration in this review, nanowired delivery of monoclonal antibodies to AβP together with ASNC and H3/H4 modulator drugs on PD brain pathology is discussed based on our own observations. Our investigation shows that TiO2 nanowired BF-2649 (1 mg/kg, i.p.) or CLBPT (1 mg/kg, i.p.) once daily for 1 week together with nanowired delivery of monoclonal antibodies (mAb) to AβP and ASNC induced superior neuroprotection in PD-induced brain pathology. These observations are the first to show the modulation of histaminergic receptors together with antibodies to AβP and ASNC induces superior neuroprotection in PD. These observations open new avenues for the development of novel drug therapies for clinical strategies in PD." @default.
- W4385146576 created "2023-07-23" @default.
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- W4385146576 date "2023-01-01" @default.
- W4385146576 modified "2023-10-18" @default.
- W4385146576 title "Nanodelivery of Histamine H3/H4 Receptor Modulators BF-2649 and Clobenpropit with Antibodies to Amyloid Beta Peptide in Combination with Alpha Synuclein Reduces Brain Pathology in Parkinson’s Disease" @default.
- W4385146576 cites W1139762711 @default.
- W4385146576 cites W1226092688 @default.
- W4385146576 cites W143399520 @default.
- W4385146576 cites W1493631176 @default.
- W4385146576 cites W1528787410 @default.
- W4385146576 cites W1575225446 @default.
- W4385146576 cites W1575298809 @default.
- W4385146576 cites W1578148915 @default.
- W4385146576 cites W1631523450 @default.
- W4385146576 cites W1642912455 @default.
- W4385146576 cites W1686669900 @default.
- W4385146576 cites W1744164530 @default.
- W4385146576 cites W1751621284 @default.
- W4385146576 cites W1835928992 @default.
- W4385146576 cites W1839459538 @default.
- W4385146576 cites W1851334881 @default.
- W4385146576 cites W1860081569 @default.
- W4385146576 cites W1863939422 @default.
- W4385146576 cites W1894795859 @default.
- W4385146576 cites W1945773664 @default.
- W4385146576 cites W1947326952 @default.
- W4385146576 cites W1965660797 @default.
- W4385146576 cites W1965927790 @default.
- W4385146576 cites W1966719113 @default.
- W4385146576 cites W1968695161 @default.
- W4385146576 cites W1969074927 @default.
- W4385146576 cites W1973093275 @default.
- W4385146576 cites W1977171645 @default.
- W4385146576 cites W1978793506 @default.
- W4385146576 cites W1979854764 @default.
- W4385146576 cites W1979854993 @default.
- W4385146576 cites W1980629470 @default.
- W4385146576 cites W1983199625 @default.
- W4385146576 cites W1986316543 @default.
- W4385146576 cites W1988251362 @default.
- W4385146576 cites W1989411375 @default.
- W4385146576 cites W1993812537 @default.
- W4385146576 cites W1996239200 @default.
- W4385146576 cites W1996285538 @default.
- W4385146576 cites W1999385317 @default.
- W4385146576 cites W2000311037 @default.
- W4385146576 cites W2001495408 @default.
- W4385146576 cites W2003719644 @default.
- W4385146576 cites W2006696253 @default.
- W4385146576 cites W2006869862 @default.
- W4385146576 cites W2019933368 @default.
- W4385146576 cites W2020067257 @default.
- W4385146576 cites W2020782494 @default.
- W4385146576 cites W2023926705 @default.
- W4385146576 cites W2024917983 @default.
- W4385146576 cites W2025593045 @default.
- W4385146576 cites W2029032298 @default.
- W4385146576 cites W2029324471 @default.
- W4385146576 cites W2029677367 @default.
- W4385146576 cites W2036008741 @default.
- W4385146576 cites W2036099970 @default.
- W4385146576 cites W2038771918 @default.
- W4385146576 cites W2039676434 @default.
- W4385146576 cites W2040042139 @default.
- W4385146576 cites W2040204696 @default.
- W4385146576 cites W2040623328 @default.
- W4385146576 cites W2041658692 @default.
- W4385146576 cites W2041937465 @default.
- W4385146576 cites W2042650337 @default.
- W4385146576 cites W2050715245 @default.
- W4385146576 cites W2053894101 @default.
- W4385146576 cites W2055007114 @default.
- W4385146576 cites W2055775902 @default.
- W4385146576 cites W2057132663 @default.
- W4385146576 cites W2058614488 @default.
- W4385146576 cites W2059742429 @default.
- W4385146576 cites W2062974472 @default.
- W4385146576 cites W2067032924 @default.
- W4385146576 cites W2067368984 @default.
- W4385146576 cites W2073741164 @default.
- W4385146576 cites W2075340389 @default.
- W4385146576 cites W2075793841 @default.
- W4385146576 cites W2078868915 @default.
- W4385146576 cites W2081204792 @default.
- W4385146576 cites W2083541023 @default.
- W4385146576 cites W2083838738 @default.
- W4385146576 cites W2084706024 @default.