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• W4385152892 startingPage "297" @default.
• W4385152892 abstract "Antibiotics are frequently used to treat infections, but despite their importance, the side effects, such as anaphylactic shock and cardiac death, can be life-threatening. In addition to drug-drug interactions (DDI), hypersensitive response remains the most prominent pathway of toxicity by which antibiotics cause their adverse effects. In addition, antibiotic-associated toxicity may be exacerbated by host-related risks such as age, sex, comorbidity, and genetic variability or by the nature of the drug itself; consequently, the characteristics of toxicity will vary between hepatotoxicity, neurotoxicity, nephrotoxicity, and antibiotic resistance. Awareness of the many patterns of antibiotic-associated toxicity and the mechanism by which adverse effects occur can enable the development of effective strategies for dealing with these effects. The consideration with antibiotic-induced toxicity may deal with the events after it occurred; however, the most valued one is how to avoid it in the first place, as dose adjustment in the state of patients with renal or hepatic dysfunction, and doing sensitivity test prior to administration of drug with expected hypersensitivity reaction. This chapter will highlight all these hottest topics that may concern the majority of physicians in addition to bringing to the light the latest research." @default.
• W4385152892 created "2023-07-23" @default.
• W4385152892 creator A5001306418 @default.
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• W4385152892 creator A5053665490 @default.
• W4385152892 creator A5076129738 @default.
• W4385152892 date "2023-01-01" @default.
• W4385152892 modified "2023-10-14" @default.
• W4385152892 title "Toxicity consideration of antibiotics" @default.
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