Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385157095> ?p ?o ?g. }
- W4385157095 abstract "Nonalcoholic fatty liver disease (NAFLD), which is an emerging global chronic liver disease, has a close association with insulin resistance. We aimed to determine whether the Gly1057Asp (rs1805097) polymorphism of the insulin receptor substrate 2 (IRS2) gene is associated with NAFLD.Using the polymerase chain reaction-restriction fragment length polymorphism method, 135 patients with biopsy-proven NAFLD and 135 controls underwent IRS2 genotype analysis.Genotype and allele distributions of the IRS2 gene Gly1057Asp variant conformed to the Hardy-Weinberg equilibrium in both the case and control groups (P > .05). The Asp/Asp genotype of IRS2 gene Gly1057Asp polymorphism compared with Gly/Gly genotype was associated with a 2.1-fold increased risk for NAFLD after adjustment for confounding factors (P = .029; odds ratio = 2.10, 95% CI = 1.23-3.97).Our findings revealed for the first time that the Gly1057Asp Asp/Asp genotype of the IRS2 gene is a marker of increased NAFLD susceptibility; however, studies in other populations are required to confirm the results." @default.
- W4385157095 created "2023-07-24" @default.
- W4385157095 creator A5005236935 @default.
- W4385157095 creator A5025934714 @default.
- W4385157095 creator A5031087741 @default.
- W4385157095 creator A5042170156 @default.
- W4385157095 creator A5045890454 @default.
- W4385157095 creator A5046096228 @default.
- W4385157095 creator A5049778348 @default.
- W4385157095 creator A5059999580 @default.
- W4385157095 creator A5061269891 @default.
- W4385157095 creator A5064627085 @default.
- W4385157095 creator A5071915277 @default.
- W4385157095 creator A5082116449 @default.
- W4385157095 creator A5091372026 @default.
- W4385157095 creator A5092524679 @default.
- W4385157095 creator A5092524680 @default.
- W4385157095 creator A5092524681 @default.
- W4385157095 date "2023-07-22" @default.
- W4385157095 modified "2023-09-27" @default.
- W4385157095 title "Insulin receptor substrate 2 gene Gly1057Asp polymorphism is a risk factor for nonalcoholic fatty liver disease" @default.
- W4385157095 cites W1697523131 @default.
- W4385157095 cites W1827607353 @default.
- W4385157095 cites W1969424517 @default.
- W4385157095 cites W1998577009 @default.
- W4385157095 cites W2025448827 @default.
- W4385157095 cites W2029027083 @default.
- W4385157095 cites W2040080456 @default.
- W4385157095 cites W2047359461 @default.
- W4385157095 cites W2047675463 @default.
- W4385157095 cites W2054910039 @default.
- W4385157095 cites W2087829753 @default.
- W4385157095 cites W2105938458 @default.
- W4385157095 cites W2106680699 @default.
- W4385157095 cites W2107163112 @default.
- W4385157095 cites W2176155742 @default.
- W4385157095 cites W2281664160 @default.
- W4385157095 cites W2479350734 @default.
- W4385157095 cites W2733241471 @default.
- W4385157095 cites W2789252658 @default.
- W4385157095 cites W2907749693 @default.
- W4385157095 cites W2946094518 @default.
- W4385157095 cites W3039996054 @default.
- W4385157095 cites W3041218311 @default.
- W4385157095 cites W3150437192 @default.
- W4385157095 cites W3156252199 @default.
- W4385157095 cites W3216681112 @default.
- W4385157095 cites W4214895759 @default.
- W4385157095 cites W4220659089 @default.
- W4385157095 cites W4311730330 @default.
- W4385157095 cites W4378711379 @default.
- W4385157095 doi "https://doi.org/10.1093/labmed/lmad066" @default.
- W4385157095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37481466" @default.
- W4385157095 hasPublicationYear "2023" @default.
- W4385157095 type Work @default.
- W4385157095 citedByCount "0" @default.
- W4385157095 crossrefType "journal-article" @default.
- W4385157095 hasAuthorship W4385157095A5005236935 @default.
- W4385157095 hasAuthorship W4385157095A5025934714 @default.
- W4385157095 hasAuthorship W4385157095A5031087741 @default.
- W4385157095 hasAuthorship W4385157095A5042170156 @default.
- W4385157095 hasAuthorship W4385157095A5045890454 @default.
- W4385157095 hasAuthorship W4385157095A5046096228 @default.
- W4385157095 hasAuthorship W4385157095A5049778348 @default.
- W4385157095 hasAuthorship W4385157095A5059999580 @default.
- W4385157095 hasAuthorship W4385157095A5061269891 @default.
- W4385157095 hasAuthorship W4385157095A5064627085 @default.
- W4385157095 hasAuthorship W4385157095A5071915277 @default.
- W4385157095 hasAuthorship W4385157095A5082116449 @default.
- W4385157095 hasAuthorship W4385157095A5091372026 @default.
- W4385157095 hasAuthorship W4385157095A5092524679 @default.
- W4385157095 hasAuthorship W4385157095A5092524680 @default.
- W4385157095 hasAuthorship W4385157095A5092524681 @default.
- W4385157095 hasConcept C104317684 @default.
- W4385157095 hasConcept C112446052 @default.
- W4385157095 hasConcept C126322002 @default.
- W4385157095 hasConcept C135763542 @default.
- W4385157095 hasConcept C156957248 @default.
- W4385157095 hasConcept C180754005 @default.
- W4385157095 hasConcept C197902417 @default.
- W4385157095 hasConcept C2776954865 @default.
- W4385157095 hasConcept C2777391703 @default.
- W4385157095 hasConcept C2778772119 @default.
- W4385157095 hasConcept C2779134260 @default.
- W4385157095 hasConcept C2779306644 @default.
- W4385157095 hasConcept C37463918 @default.
- W4385157095 hasConcept C54355233 @default.
- W4385157095 hasConcept C71924100 @default.
- W4385157095 hasConcept C76252995 @default.
- W4385157095 hasConcept C86803240 @default.
- W4385157095 hasConcept C90924648 @default.
- W4385157095 hasConceptScore W4385157095C104317684 @default.
- W4385157095 hasConceptScore W4385157095C112446052 @default.
- W4385157095 hasConceptScore W4385157095C126322002 @default.
- W4385157095 hasConceptScore W4385157095C135763542 @default.
- W4385157095 hasConceptScore W4385157095C156957248 @default.
- W4385157095 hasConceptScore W4385157095C180754005 @default.
- W4385157095 hasConceptScore W4385157095C197902417 @default.
- W4385157095 hasConceptScore W4385157095C2776954865 @default.
- W4385157095 hasConceptScore W4385157095C2777391703 @default.