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- W4385157096 abstract "Abstract Neuroinflammation has been implicated in the initiation and progression of several central nervous system (CNS) disorders, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, ischemic stroke, traumatic brain injury, spinal cord injury, viral encephalitis, and bacterial encephalitis. Microglia and astrocytes are essential in neural development, maintenance of synaptic connections, and homeostasis in a healthy brain. The activation of astrocytes and microglia is a defense mechanism of the brain against damaged tissues and harmful pathogens. However, their activation triggers neuroinflammation, which can exacerbate or induce CNS injury. Non-coding RNAs (ncRNAs) are functional RNA molecules that lack coding capabilities but can actively regulate mRNA expression and function through various mechanisms. ncRNAs are highly expressed in astrocytes and microglia and are potential mediators of neuroinflammation. We reviewed the recent research progress on the role of miRNAs, lncRNAs, and circRNAs in regulating neuroinflammation in various CNS diseases. Understanding how these ncRNAs affect neuroinflammation will provide important therapeutic insights for preventing and managing CNS dysfunction." @default.
- W4385157096 created "2023-07-24" @default.
- W4385157096 creator A5025896370 @default.
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- W4385157096 creator A5074707535 @default.
- W4385157096 creator A5083930812 @default.
- W4385157096 creator A5086248839 @default.
- W4385157096 date "2023-07-23" @default.
- W4385157096 modified "2023-10-18" @default.
- W4385157096 title "Emerging role of non-coding RNAs in neuroinflammation mediated by microglia and astrocytes" @default.
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