Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385161887> ?p ?o ?g. }
- W4385161887 abstract "ABSTRACT In adult mammalian central nervous system (CNS) neurons, axon regeneration after injury remains limited due to unfavorable gene regulatory programs. Factors enabling comprehensive epigenetic and transcriptional transitions, for instance, pivotal transcription factors that mediate neurogenesis and morphogenesis may be sufficient to promote CNS axon regeneration. Based on the analyses of multiple public whole-genome RNA and chromatin accessibility sequencing dataset of mouse retina development, as well as previous functional studies on the regeneration-capable dorsal root ganglion neurons, we hypothesize that the overexpression of pioneer transcription factor Achaete-Scute homolog 1 (Ascl1) would promote axon regeneration in the adult mammalian CNS neurons. We employed the optic nerve crush in mice, a common model for studying CNS axon regeneration, neuron survival and glaucoma, to investigate the effect of Ascl1 overexpression on the post-injury optic nerve regeneration. We found that Ascl1 could sufficiently promote regenerated axons past the crush site and significantly preserve the survival of retinal ganglion cells. Mechanistically, we revealed that effects of Ascl1 was mediated by known pro-regeneration factor Sox11 but not others. Together, our study established an effective workflow combined with the integrated computational inference and experimental validation for discovering functionally important target for promoting CNS neuron axon regeneration and survival." @default.
- W4385161887 created "2023-07-24" @default.
- W4385161887 creator A5005509338 @default.
- W4385161887 creator A5011174545 @default.
- W4385161887 creator A5054214253 @default.
- W4385161887 creator A5064513160 @default.
- W4385161887 creator A5072216739 @default.
- W4385161887 creator A5080400345 @default.
- W4385161887 date "2023-07-23" @default.
- W4385161887 modified "2023-10-17" @default.
- W4385161887 title "Targeting pioneer transcription factor Ascl1 to promote optic nerve regeneration" @default.
- W4385161887 cites W1961928125 @default.
- W4385161887 cites W1964392512 @default.
- W4385161887 cites W1967273876 @default.
- W4385161887 cites W1970901436 @default.
- W4385161887 cites W1975473847 @default.
- W4385161887 cites W1982908050 @default.
- W4385161887 cites W1992413639 @default.
- W4385161887 cites W1992902970 @default.
- W4385161887 cites W2002314797 @default.
- W4385161887 cites W2028585054 @default.
- W4385161887 cites W2050065221 @default.
- W4385161887 cites W2066897354 @default.
- W4385161887 cites W2077455826 @default.
- W4385161887 cites W2084502772 @default.
- W4385161887 cites W2095263564 @default.
- W4385161887 cites W2102577577 @default.
- W4385161887 cites W2105989397 @default.
- W4385161887 cites W2108839057 @default.
- W4385161887 cites W2113377982 @default.
- W4385161887 cites W2114128247 @default.
- W4385161887 cites W2117962491 @default.
- W4385161887 cites W2118263932 @default.
- W4385161887 cites W2122097157 @default.
- W4385161887 cites W2129282939 @default.
- W4385161887 cites W2130367422 @default.
- W4385161887 cites W2132259121 @default.
- W4385161887 cites W2138427488 @default.
- W4385161887 cites W2138921976 @default.
- W4385161887 cites W2146716101 @default.
- W4385161887 cites W2146821633 @default.
- W4385161887 cites W2162203253 @default.
- W4385161887 cites W2162892919 @default.
- W4385161887 cites W2335534790 @default.
- W4385161887 cites W2440302195 @default.
- W4385161887 cites W2606711615 @default.
- W4385161887 cites W2640197197 @default.
- W4385161887 cites W2737675606 @default.
- W4385161887 cites W2750740711 @default.
- W4385161887 cites W2760849110 @default.
- W4385161887 cites W2789281724 @default.
- W4385161887 cites W2792470996 @default.
- W4385161887 cites W2793015531 @default.
- W4385161887 cites W2793389999 @default.
- W4385161887 cites W2802879466 @default.
- W4385161887 cites W2805567320 @default.
- W4385161887 cites W2885013112 @default.
- W4385161887 cites W2891938650 @default.
- W4385161887 cites W2896045573 @default.
- W4385161887 cites W2904453831 @default.
- W4385161887 cites W2952173156 @default.
- W4385161887 cites W2952761939 @default.
- W4385161887 cites W2966903091 @default.
- W4385161887 cites W2971240433 @default.
- W4385161887 cites W2990382732 @default.
- W4385161887 cites W3014366315 @default.
- W4385161887 cites W3017177954 @default.
- W4385161887 cites W3025176503 @default.
- W4385161887 cites W3029117442 @default.
- W4385161887 cites W3087555036 @default.
- W4385161887 cites W3127973360 @default.
- W4385161887 cites W3153529793 @default.
- W4385161887 cites W3187045755 @default.
- W4385161887 cites W3212477617 @default.
- W4385161887 cites W4205747768 @default.
- W4385161887 cites W4224228718 @default.
- W4385161887 cites W4226078389 @default.
- W4385161887 cites W4229079991 @default.
- W4385161887 cites W4232737588 @default.
- W4385161887 cites W4247333492 @default.
- W4385161887 cites W4292338021 @default.
- W4385161887 cites W4306174878 @default.
- W4385161887 cites W82040228 @default.
- W4385161887 doi "https://doi.org/10.1101/2023.07.20.549959" @default.
- W4385161887 hasPublicationYear "2023" @default.
- W4385161887 type Work @default.
- W4385161887 citedByCount "0" @default.
- W4385161887 crossrefType "posted-content" @default.
- W4385161887 hasAuthorship W4385161887A5005509338 @default.
- W4385161887 hasAuthorship W4385161887A5011174545 @default.
- W4385161887 hasAuthorship W4385161887A5054214253 @default.
- W4385161887 hasAuthorship W4385161887A5064513160 @default.
- W4385161887 hasAuthorship W4385161887A5072216739 @default.
- W4385161887 hasAuthorship W4385161887A5080400345 @default.
- W4385161887 hasBestOaLocation W43851618871 @default.
- W4385161887 hasConcept C104317684 @default.
- W4385161887 hasConcept C169760540 @default.
- W4385161887 hasConcept C171056886 @default.
- W4385161887 hasConcept C2779530196 @default.
- W4385161887 hasConcept C2780837183 @default.