Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385185870> ?p ?o ?g. }
- W4385185870 endingPage "10" @default.
- W4385185870 startingPage "1" @default.
- W4385185870 abstract "Previous evidence on antidepressant medication and cardiovascular disease (CVD) among patients with posttraumatic stress disorder (PTSD) has been inconclusive. We estimated the association between antidepressant medication and CVD by applying a marginal structural model.We analyzed medical utilization records of 27 170 people with PTSD without prior major cardiovascular events in the Korean National Health Insurance Database (NHID). PTSD and CVD were defined in accordance with the recorded ICD-10 diagnostic codes. We acquired information on antidepressant use from the NHID and categorized them by medication type. A composite major adverse cardiovascular events (MACE) outcome was defined as coronary artery disease with revascularization, ischaemic stroke, and/or haemorrhagic stroke. We used inverse probability of treatment weighting to estimate the parameters of a marginal structural discrete-time survival analysis regression model, comparing the resulting estimates to those derived from traditional time-fixed and time-varying Cox proportional hazards regression. We calculated cumulative daily defined doses to test for a dose-response relationship.People exposed to antidepressants showed a higher hazard of MACE [hazard ratio (HR) 1.34, 95% confidence interval (CI) 1.18-1.53]. The estimated effects were strongest for selective serotonin reuptake inhibitors (HR 1.24, 95% CI 1.08-1.44) and TCAs (HR 1.33, 95% CI 1.13-1.56). Exposure to serotonin-norepinephrine reuptake inhibitors did not appear to increase the risk of MACE. People exposed to higher doses of antidepressants showed higher risk of MACE.In a national cohort of people with PTSD, exposure to antidepressant medications increased the risk of MACE in a dose-response fashion." @default.
- W4385185870 created "2023-07-25" @default.
- W4385185870 creator A5006751010 @default.
- W4385185870 creator A5020588795 @default.
- W4385185870 creator A5023704206 @default.
- W4385185870 creator A5067147989 @default.
- W4385185870 creator A5084259282 @default.
- W4385185870 creator A5091101403 @default.
- W4385185870 date "2023-07-24" @default.
- W4385185870 modified "2023-09-26" @default.
- W4385185870 title "A marginal structural model to estimate the effect of antidepressant medication treatment on major cardiovascular events among people with post-traumatic stress disorder" @default.
- W4385185870 cites W1983940079 @default.
- W4385185870 cites W1985698052 @default.
- W4385185870 cites W1986531594 @default.
- W4385185870 cites W1987277835 @default.
- W4385185870 cites W1989811349 @default.
- W4385185870 cites W1997712205 @default.
- W4385185870 cites W2008557562 @default.
- W4385185870 cites W2009187570 @default.
- W4385185870 cites W2013932263 @default.
- W4385185870 cites W2024993254 @default.
- W4385185870 cites W2046999130 @default.
- W4385185870 cites W2058552826 @default.
- W4385185870 cites W2060124746 @default.
- W4385185870 cites W2085437790 @default.
- W4385185870 cites W2099849803 @default.
- W4385185870 cites W2108933823 @default.
- W4385185870 cites W2114877987 @default.
- W4385185870 cites W2132135389 @default.
- W4385185870 cites W2142495742 @default.
- W4385185870 cites W2146408281 @default.
- W4385185870 cites W2150300473 @default.
- W4385185870 cites W2172555405 @default.
- W4385185870 cites W2489304329 @default.
- W4385185870 cites W2517170026 @default.
- W4385185870 cites W2539020782 @default.
- W4385185870 cites W2570146422 @default.
- W4385185870 cites W2730624419 @default.
- W4385185870 cites W2735301415 @default.
- W4385185870 cites W2790997036 @default.
- W4385185870 cites W2793969991 @default.
- W4385185870 cites W2889028954 @default.
- W4385185870 cites W2890441882 @default.
- W4385185870 cites W2944117756 @default.
- W4385185870 cites W2951356588 @default.
- W4385185870 cites W2974351413 @default.
- W4385185870 cites W2978250214 @default.
- W4385185870 cites W2987667831 @default.
- W4385185870 cites W3004095885 @default.
- W4385185870 cites W3022396412 @default.
- W4385185870 cites W3112039321 @default.
- W4385185870 cites W3112798526 @default.
- W4385185870 cites W3135929794 @default.
- W4385185870 cites W3156982216 @default.
- W4385185870 cites W3183210830 @default.
- W4385185870 cites W3211659156 @default.
- W4385185870 cites W4248475094 @default.
- W4385185870 cites W4283789028 @default.
- W4385185870 cites W428649500 @default.
- W4385185870 doi "https://doi.org/10.1017/s0033291723001873" @default.
- W4385185870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37485701" @default.
- W4385185870 hasPublicationYear "2023" @default.
- W4385185870 type Work @default.
- W4385185870 citedByCount "0" @default.
- W4385185870 crossrefType "journal-article" @default.
- W4385185870 hasAuthorship W4385185870A5006751010 @default.
- W4385185870 hasAuthorship W4385185870A5020588795 @default.
- W4385185870 hasAuthorship W4385185870A5023704206 @default.
- W4385185870 hasAuthorship W4385185870A5067147989 @default.
- W4385185870 hasAuthorship W4385185870A5084259282 @default.
- W4385185870 hasAuthorship W4385185870A5091101403 @default.
- W4385185870 hasBestOaLocation W43851858701 @default.
- W4385185870 hasConcept C118552586 @default.
- W4385185870 hasConcept C126322002 @default.
- W4385185870 hasConcept C207103383 @default.
- W4385185870 hasConcept C2776466888 @default.
- W4385185870 hasConcept C2779177272 @default.
- W4385185870 hasConcept C2780400711 @default.
- W4385185870 hasConcept C2780739214 @default.
- W4385185870 hasConcept C2781161787 @default.
- W4385185870 hasConcept C44249647 @default.
- W4385185870 hasConcept C500558357 @default.
- W4385185870 hasConcept C50382708 @default.
- W4385185870 hasConcept C71924100 @default.
- W4385185870 hasConcept C72563966 @default.
- W4385185870 hasConceptScore W4385185870C118552586 @default.
- W4385185870 hasConceptScore W4385185870C126322002 @default.
- W4385185870 hasConceptScore W4385185870C207103383 @default.
- W4385185870 hasConceptScore W4385185870C2776466888 @default.
- W4385185870 hasConceptScore W4385185870C2779177272 @default.
- W4385185870 hasConceptScore W4385185870C2780400711 @default.
- W4385185870 hasConceptScore W4385185870C2780739214 @default.
- W4385185870 hasConceptScore W4385185870C2781161787 @default.
- W4385185870 hasConceptScore W4385185870C44249647 @default.
- W4385185870 hasConceptScore W4385185870C500558357 @default.
- W4385185870 hasConceptScore W4385185870C50382708 @default.
- W4385185870 hasConceptScore W4385185870C71924100 @default.
- W4385185870 hasConceptScore W4385185870C72563966 @default.