Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385185991> ?p ?o ?g. }
- W4385185991 abstract "Abstract G protein‐coupled receptors (GPCRs) are the largest and most diverse class of signaling receptors. GPCRs regulate many functions in the human body and have earned the title of “most targeted receptors”. About one‐third of the commercially available drugs for various diseases target the GPCRs. Fibroblasts lay the architectural skeleton of the body, and play a key role in supporting the growth, maintenance, and repair of almost all tissues by responding to the cellular cues via diverse and intricate GPCR signaling pathways. This review discusses the dynamic architecture of the GPCRs and their intertwined signaling in pathological conditions such as idiopathic pulmonary fibrosis, cardiac fibrosis, pancreatic fibrosis, hepatic fibrosis, and cancer as opposed to the GPCR signaling of fibroblasts in physiological conditions. Understanding the dynamics of GPCR signaling in fibroblasts with disease progression can help in the recognition of the complex interplay of different GPCR subtypes in fibroblast‐mediated diseases. This review highlights the importance of designing and adaptation of next‐generation strategies such as GPCR‐omics, focused target identification, polypharmacology, and effective personalized medicine approaches to achieve better therapeutic outcomes for fibrosis and fibrosis associated malignancies." @default.
- W4385185991 created "2023-07-25" @default.
- W4385185991 creator A5002575123 @default.
- W4385185991 creator A5041783537 @default.
- W4385185991 creator A5044066292 @default.
- W4385185991 creator A5046876907 @default.
- W4385185991 creator A5082834225 @default.
- W4385185991 creator A5085256777 @default.
- W4385185991 creator A5090154787 @default.
- W4385185991 date "2023-07-24" @default.
- W4385185991 modified "2023-10-17" @default.
- W4385185991 title "<scp>GPCRs</scp> and fibroblast heterogeneity in fibroblast‐associated diseases" @default.
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