Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385186143> ?p ?o ?g. }
- W4385186143 endingPage "291" @default.
- W4385186143 startingPage "280" @default.
- W4385186143 abstract "Pulp-Dentin regeneration is a key aspect of maintain tooth vitality and enabling good oral-systemic health. This study aimed to investigate a nanofibrous scaffold loaded with a small molecule i.e. Tideglusib to promote odontogenic differentiation. Tideglusib (GSK-3β inhibitor) interaction with GSK-3β was determined using molecular docking and stabilization of β-catenin was examined by confocal microscopy. 3D nanofibrous scaffolds were fabricated through electrospinning and their physicochemical characterizations were performed. Scaffolds were seeded with mesenchymal stem cells or pre-odontoblast cells to determine the cells proliferation and odontogenic differentiation. Our results showed that Tideglusib (TG) binds with GSK-3β at Cys199 residue. Stabilization and nuclear translocation of β-catenin was increased in the odontoblast cells treated with TG. SEM analysis revealed that nanofibers exhibited controlled architectural features that effectively mimicked the natural ECM. UV-Vis spectroscopy demonstrated that TG was incorporated successfully and released in a controlled manner. Both kinds of biomimetic nanofibrous matrices (PCLF-TG100, PCLF-TG1000) significantly stimulated cells proliferation. Furthermore, these scaffolds significantly induced dentinogenic markers (ALP, and DSPP) expression and biomineralization. In contrast to current pulp capping material driving dentin repair, the sophisticated, polymeric scaffold systems with soluble and insoluble spatiotemporal cues described here can direct stem cell differentiation and dentin regeneration. Hence, bioactive small molecule-incorporated nanofibrous scaffold suggests an innovative clinical tool for dentin tissue engineering." @default.
- W4385186143 created "2023-07-25" @default.
- W4385186143 creator A5039133996 @default.
- W4385186143 creator A5046946008 @default.
- W4385186143 creator A5048101548 @default.
- W4385186143 creator A5058646093 @default.
- W4385186143 creator A5059798414 @default.
- W4385186143 creator A5077443022 @default.
- W4385186143 creator A5082554430 @default.
- W4385186143 creator A5084906661 @default.
- W4385186143 creator A5089961917 @default.
- W4385186143 creator A5090792144 @default.
- W4385186143 date "2023-07-24" @default.
- W4385186143 modified "2023-10-18" @default.
- W4385186143 title "Tideglusib-incorporated nanofibrous scaffolds potently induce odontogenic differentiation" @default.
- W4385186143 cites W1503205107 @default.
- W4385186143 cites W1977180007 @default.
- W4385186143 cites W1995030063 @default.
- W4385186143 cites W2033224500 @default.
- W4385186143 cites W2035376760 @default.
- W4385186143 cites W2037428602 @default.
- W4385186143 cites W2039218697 @default.
- W4385186143 cites W2039364468 @default.
- W4385186143 cites W2055327846 @default.
- W4385186143 cites W2061423969 @default.
- W4385186143 cites W2086588103 @default.
- W4385186143 cites W2110200535 @default.
- W4385186143 cites W2126693515 @default.
- W4385186143 cites W2131931339 @default.
- W4385186143 cites W2139915497 @default.
- W4385186143 cites W2143171795 @default.
- W4385186143 cites W2145538381 @default.
- W4385186143 cites W2147705448 @default.
- W4385186143 cites W2151460035 @default.
- W4385186143 cites W2160845211 @default.
- W4385186143 cites W2169379013 @default.
- W4385186143 cites W2290593915 @default.
- W4385186143 cites W244146819 @default.
- W4385186143 cites W2465262359 @default.
- W4385186143 cites W2568491470 @default.
- W4385186143 cites W2591889896 @default.
- W4385186143 cites W2743800043 @default.
- W4385186143 cites W2767375580 @default.
- W4385186143 cites W2769708102 @default.
- W4385186143 cites W2800300792 @default.
- W4385186143 cites W2888278972 @default.
- W4385186143 cites W3011224442 @default.
- W4385186143 cites W3022282161 @default.
- W4385186143 cites W3035115782 @default.
- W4385186143 cites W3077717405 @default.
- W4385186143 cites W3092587099 @default.
- W4385186143 cites W3109746568 @default.
- W4385186143 cites W3126828696 @default.
- W4385186143 cites W3140632601 @default.
- W4385186143 cites W3159824894 @default.
- W4385186143 cites W3163575694 @default.
- W4385186143 cites W3206934545 @default.
- W4385186143 cites W4205816675 @default.
- W4385186143 cites W4213426517 @default.
- W4385186143 cites W4308150421 @default.
- W4385186143 doi "https://doi.org/10.1177/08853282231190470" @default.
- W4385186143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37485690" @default.
- W4385186143 hasPublicationYear "2023" @default.
- W4385186143 type Work @default.
- W4385186143 citedByCount "1" @default.
- W4385186143 countsByYear W43851861432023 @default.
- W4385186143 crossrefType "journal-article" @default.
- W4385186143 hasAuthorship W4385186143A5039133996 @default.
- W4385186143 hasAuthorship W4385186143A5046946008 @default.
- W4385186143 hasAuthorship W4385186143A5048101548 @default.
- W4385186143 hasAuthorship W4385186143A5058646093 @default.
- W4385186143 hasAuthorship W4385186143A5059798414 @default.
- W4385186143 hasAuthorship W4385186143A5077443022 @default.
- W4385186143 hasAuthorship W4385186143A5082554430 @default.
- W4385186143 hasAuthorship W4385186143A5084906661 @default.
- W4385186143 hasAuthorship W4385186143A5089961917 @default.
- W4385186143 hasAuthorship W4385186143A5090792144 @default.
- W4385186143 hasConcept C12554922 @default.
- W4385186143 hasConcept C136229726 @default.
- W4385186143 hasConcept C144796933 @default.
- W4385186143 hasConcept C159985019 @default.
- W4385186143 hasConcept C161312837 @default.
- W4385186143 hasConcept C171056886 @default.
- W4385186143 hasConcept C171250308 @default.
- W4385186143 hasConcept C188442228 @default.
- W4385186143 hasConcept C192562407 @default.
- W4385186143 hasConcept C198826908 @default.
- W4385186143 hasConcept C199343813 @default.
- W4385186143 hasConcept C2520015 @default.
- W4385186143 hasConcept C2777400515 @default.
- W4385186143 hasConcept C2779203663 @default.
- W4385186143 hasConcept C2779263046 @default.
- W4385186143 hasConcept C28328180 @default.
- W4385186143 hasConcept C49892992 @default.
- W4385186143 hasConcept C521977710 @default.
- W4385186143 hasConcept C69103154 @default.
- W4385186143 hasConcept C71924100 @default.
- W4385186143 hasConcept C86803240 @default.