Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385186412> ?p ?o ?g. }
- W4385186412 endingPage "270" @default.
- W4385186412 startingPage "263" @default.
- W4385186412 abstract "Abstract Purpose of Review The purpose of this review is to overview the most relevant and recent knowledge regarding medical management in pulmonary arterial hypertension (PAH) . Recent Findings Evidence has shown that PAH patients’ quality of life and prognosis depend on the capability of the RV to adapt to increased afterload and to fully recover in response to substantially reduced pulmonary vascular resistance obtained with medical therapy. Data from recent clinical studies show that more aggressive treatment strategies, especially in higher risk categories, determine larger afterload reductions, consequentially increasing the probability of achieving right heart reverse remodeling, therefore improving the patients’ survival and quality of life. Remarkable progress has been observed over the past decades in the medical treatment of PAH, related to the development of drugs that target multiple biological pathways, strategies for earlier and more aggressive treatment interventions. Summary New hopes for treatment of patients who are unable to achieve low-risk status have been derived from the phase 2 trial PULSAR and the phase 3 trial STELLAR, which show improvement in the hemodynamic status of patients treated with sotatercept on top of background therapy. Promising results are expected from several ongoing clinical trials targeting new pathways involved in the pathophysiology of PAH." @default.
- W4385186412 created "2023-07-25" @default.
- W4385186412 creator A5000267919 @default.
- W4385186412 creator A5002231322 @default.
- W4385186412 creator A5007480230 @default.
- W4385186412 creator A5011520361 @default.
- W4385186412 creator A5036888937 @default.
- W4385186412 creator A5048004452 @default.
- W4385186412 creator A5055684454 @default.
- W4385186412 creator A5057468113 @default.
- W4385186412 creator A5078616038 @default.
- W4385186412 creator A5084537986 @default.
- W4385186412 creator A5087502708 @default.
- W4385186412 date "2023-07-24" @default.
- W4385186412 modified "2023-10-01" @default.
- W4385186412 title "Medical Management of Right Ventricular Dysfunction in Pulmonary Arterial Hypertension" @default.
- W4385186412 cites W1825951622 @default.
- W4385186412 cites W1929000169 @default.
- W4385186412 cites W1979770196 @default.
- W4385186412 cites W1983657617 @default.
- W4385186412 cites W2004567083 @default.
- W4385186412 cites W2014500068 @default.
- W4385186412 cites W2043759232 @default.
- W4385186412 cites W2058485634 @default.
- W4385186412 cites W2061627198 @default.
- W4385186412 cites W2064446419 @default.
- W4385186412 cites W2075630317 @default.
- W4385186412 cites W2079912936 @default.
- W4385186412 cites W2083412870 @default.
- W4385186412 cites W2112229901 @default.
- W4385186412 cites W2114054209 @default.
- W4385186412 cites W2146177859 @default.
- W4385186412 cites W2147944062 @default.
- W4385186412 cites W2169799265 @default.
- W4385186412 cites W2170779936 @default.
- W4385186412 cites W2261574050 @default.
- W4385186412 cites W2303061015 @default.
- W4385186412 cites W2329884795 @default.
- W4385186412 cites W2739994881 @default.
- W4385186412 cites W2745348282 @default.
- W4385186412 cites W2751121827 @default.
- W4385186412 cites W2762921017 @default.
- W4385186412 cites W2904085911 @default.
- W4385186412 cites W2954180981 @default.
- W4385186412 cites W2976953338 @default.
- W4385186412 cites W2989138579 @default.
- W4385186412 cites W3036216389 @default.
- W4385186412 cites W3082715756 @default.
- W4385186412 cites W3138574248 @default.
- W4385186412 cites W3152050105 @default.
- W4385186412 cites W3161074857 @default.
- W4385186412 cites W3174814045 @default.
- W4385186412 cites W3201735854 @default.
- W4385186412 cites W3208029444 @default.
- W4385186412 cites W3208908245 @default.
- W4385186412 cites W4200299300 @default.
- W4385186412 cites W4200519994 @default.
- W4385186412 cites W4223504984 @default.
- W4385186412 cites W4281290585 @default.
- W4385186412 cites W4293217384 @default.
- W4385186412 cites W4301585911 @default.
- W4385186412 cites W4308708678 @default.
- W4385186412 cites W4323293924 @default.
- W4385186412 doi "https://doi.org/10.1007/s11897-023-00612-2" @default.
- W4385186412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37486563" @default.
- W4385186412 hasPublicationYear "2023" @default.
- W4385186412 type Work @default.
- W4385186412 citedByCount "0" @default.
- W4385186412 crossrefType "journal-article" @default.
- W4385186412 hasAuthorship W4385186412A5000267919 @default.
- W4385186412 hasAuthorship W4385186412A5002231322 @default.
- W4385186412 hasAuthorship W4385186412A5007480230 @default.
- W4385186412 hasAuthorship W4385186412A5011520361 @default.
- W4385186412 hasAuthorship W4385186412A5036888937 @default.
- W4385186412 hasAuthorship W4385186412A5048004452 @default.
- W4385186412 hasAuthorship W4385186412A5055684454 @default.
- W4385186412 hasAuthorship W4385186412A5057468113 @default.
- W4385186412 hasAuthorship W4385186412A5078616038 @default.
- W4385186412 hasAuthorship W4385186412A5084537986 @default.
- W4385186412 hasAuthorship W4385186412A5087502708 @default.
- W4385186412 hasBestOaLocation W43851864121 @default.
- W4385186412 hasConcept C118552586 @default.
- W4385186412 hasConcept C123576724 @default.
- W4385186412 hasConcept C126322002 @default.
- W4385186412 hasConcept C159110408 @default.
- W4385186412 hasConcept C164705383 @default.
- W4385186412 hasConcept C177713679 @default.
- W4385186412 hasConcept C178853913 @default.
- W4385186412 hasConcept C27415008 @default.
- W4385186412 hasConcept C2777010666 @default.
- W4385186412 hasConcept C2778789114 @default.
- W4385186412 hasConcept C2779951463 @default.
- W4385186412 hasConcept C2780930700 @default.
- W4385186412 hasConcept C535046627 @default.
- W4385186412 hasConcept C58245268 @default.
- W4385186412 hasConcept C71924100 @default.
- W4385186412 hasConceptScore W4385186412C118552586 @default.
- W4385186412 hasConceptScore W4385186412C123576724 @default.