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- W4385187878 abstract "Background and Aim: The platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been studied widely in cancer diseases. However, their correlation with hepatitis C virus (HCV) infection is unknown. This study aimed to investigate the correlation of PLR and NLR with disease severity in patients with HCV-related liver disease in comparison with fibroscan. Methods: One hundred patients were enrolled. Physical examination, BMI, liver function tests, serum creatinine, complete blood count, serum HCV RNA count by PCR, and abdominal ultrasonography were performed. Transient elastography measurements using FibroScan were performed. Patients were classified into those with mild fibrosis (F1–F3) and significant fibrosis (F4). APRI and FIB-4, NLR, and PLR were calculated. Results: The average age of the study patients was 46.42± 10.9 years, mainly men (n=63; 63%). PLR was lower in patients with significant fibrosis F4 vs non-F4 (74.58 ± 40.30 vs 121.59 ± 53.42; P=0.001). APRI and FIB-4 were calculated similarly with PLR (P <0.05) in significant fibrosis. Age, platelet count, Total serum bilirubin, liver stiffness, APRI, FIB-4, and PLR were predictors of significant fibrosis (P<0.05). Conclusion: PLR can therefore be used as a simple serological marker along with APRI and FIB-4 for the assessment of advanced fibrosis in resource-limited healthcare settings, or by decreasing economic burden when stratifying patients with significant fibrosis that requires other non-invasive markers to be stratified." @default.
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- W4385187878 date "2023-01-01" @default.
- W4385187878 modified "2023-10-01" @default.
- W4385187878 title "Role of Platelet to Lymphocyte Ratio in Assessing Liver Fibrosis in Chronic Hepatitis C Infection" @default.
- W4385187878 doi "https://doi.org/10.1016/j.jceh.2023.07.096" @default.
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