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- W4385187894 abstract "Background and Aim: The data regarding the impact of pre transplant rectal colonisation with Carbapenem Resistant Enterobacterales (CRE) and Vancomycin Resistance Enterococci (VRE) organisms on post-transplant outcomes in patients undergoing Liver Transplant, in India is scarce. The aim of this study was to assess the prevalence of CRE, VRE rectal colonization and its impact on post-transplant outcomes in liver recipients. Methods: We did a retrospective cohort study of patients undergoing liver transplant from Jan 2022 to Jan 2023 at our centre. We analysed the prevalence of CRE, VRE colonization in rectal swab and data related to post transplant CRE, VRE infections & mortality from patients records till 3 months post-transplant. Results: Amongst the 119 patients (79% males) with median age of 45 years, the prevalence of pretransplant CRE and VRE colonization was 32/118 (27.11%) and 9/117 (7.69%) respectively. At a follow up of three months, 20/117(17.09%) and 2/117 (1.71%) patients had developed post-transplant infection with CRE and VRE organisms respectively. In patients who were pretransplant colonized with CRE in the rectal swab, the risk of CRE infection (22.6% vs 15.3 %, OR 1.61) [CI 0.57-4.51] and mortality (12.5% vs 4.7% OR 2.92) [CI 0.68- 12.49] within 3 months post-transplant were numerically higher but not statistically significant. There was no association of pre transplant VRE colonization on post-transplant VRE infection and mortality. Post-transplant CRE and VRE infection was not associated with any increase in post-transplant mortality. Conclusion: There is high prevalence of CRE rectal colonization (27.11%) in patients undergoing liver transplantation in this study. In these CRE colonized recipients, there is an increased risk of CRE infection & mortality though not statistically significant. This raises issue of choice of preoperative prophylactic antibiotic and the need for change in those who are noted to be colonized with CRE organism." @default.
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- W4385187894 date "2023-01-01" @default.
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- W4385187894 title "Prevalence and Impact of Pre-Transplant Carbapenem Resistant Enterobacterales (CRE) And Vancomycin Resistance Enterococci (VRE) Rectal Colonization On Post Liver Transplant Outcomes." @default.
- W4385187894 doi "https://doi.org/10.1016/j.jceh.2023.07.118" @default.
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