Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385188995> ?p ?o ?g. }
- W4385188995 abstract "Abstract Temperature is one of the key determinants of microbial behavior and survival, whose impact is typically studied under heat- or cold-shock conditions that elicit specific regulation to combat lethal stress. At intermediate temperatures, cellular growth rate varies according to the Arrhenius law of thermodynamics without stress responses, a behavior whose origins have not yet been elucidated. Using single-cell microscopy during temperature perturbations, we show that bacteria exhibit a highly conserved, gradual response to temperature upshifts with a time scale of ∼1.5 doublings at the higher temperature, regardless of initial/final temperature or nutrient source. We find that this behavior is coupled to a temperature memory, which we rule out as being neither transcriptional, translational, nor membrane dependent. Instead, we demonstrate that an autocatalytic enzyme network incorporating temperature-sensitive Michaelis-Menten kinetics recapitulates all temperature-shift dynamics through metabolome rearrangement, which encodes a temperature memory and successfully predicts alterations in the upshift response observed under simple-sugar, low-nutrient conditions, and in fungi. This model also provides a mechanistic framework for both Arrhenius-dependent growth and the classical Monod Equation through temperature-dependent metabolite flux." @default.
- W4385188995 created "2023-07-25" @default.
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- W4385188995 date "2023-07-24" @default.
- W4385188995 modified "2023-10-10" @default.
- W4385188995 title "Metabolomic rearrangement controls the intrinsic microbial response to temperature changes" @default.
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- W4385188995 doi "https://doi.org/10.1101/2023.07.22.550177" @default.
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