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- W4385192110 abstract "There were an estimated 247 million clinical episodes and 619 000 deaths due to malaria in 2021. 1 WHOWorld Malaria Report 2021. World Health Organization, Geneva2021 Google Scholar Stalled progress in reducing the global malaria burden since 2015 highlights the need for new interventions to interrupt malaria transmission and enable malaria elimination. A vaccine that prevents malaria transmission and can be implemented at scale could be transformative. This could be achieved by the development of vaccines that are highly effective in preventing infection as well as clinical illness, and therefore reduce onward transmission. However, developing vaccines with a high level of protective immunity against infection has been challenging. 2 Beeson JG Kurtovic L Dobaño C et al. Challenges and strategies for developing efficacious and long-lasting malaria vaccines. Sci Transl Med. 2019; 11eaau1458 Crossref PubMed Scopus (69) Google Scholar An alternative approach is to develop vaccines specifically designed to prevent malaria transmission to mosquitoes, known as transmission-blocking vaccines (figure). Malaria transmission-blocking vaccines Pfs230D1-EPA and Pfs25-EPA in Alhydrogel in healthy Malian adults; a phase 1, randomised, controlled trialPfs230D1 but not Pfs25 vaccine induces durable serum functional activity in Malian adults. Direct skin feed assays detect parasite transmission to mosquitoes but increased event rates are needed to assess vaccine effectiveness. Full-Text PDF" @default.
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- W4385192110 date "2023-07-01" @default.
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- W4385192110 title "A step forward for Plasmodium falciparum malaria transmission-blocking vaccines" @default.
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- W4385192110 doi "https://doi.org/10.1016/s1473-3099(23)00288-8" @default.
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