Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385192794> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4385192794 abstract "Human Papillomavirus (HPV) is one of the principal causes of death among females in emerging nations. It is a sexually transmitted virus that shatters the cell cycle by two of its oncoproteins i.e., E6 and E7. HPV E7 oncoprotein binds to the pRb (Retinoblastoma tumor suppressor gene). This binding hinders the association of pRb with E2F causing the release of transcription factor E2F, vital for the cell cycle to proceed for the S phase thus causing abnormal unregulated cell division and growth. Precautionary HPV Vaccines are available, however infected populations are deprived of therapeutic treatments based on drugs. To rectify this issue, we try to recognize bioactive molecule inhibitors of the HPV E7 oncoprotein using bioinformatics softwares and in-silico molecular docking. In this in-silico study, flavonoid compounds were virtually screened and observed for their ability to inhibit E7 oncoprotein. The virtual screening was conducted in several steps starting with molecular docking to find their potential binding energy with the target followed by validating results with machine learning using Python. According to the literature review Baicalein is considered as a most potent inhibitor of E7 (taken as control). In this study, we worked on approximately 50 flavonoids out of which 15 have shown significant binding energies. Usually, the bioactive compounds present in flavonoids will not significantly cause a side effect. Linarin has shown maximum binding energy of ΔG -10.6 kcal/mol comparable to that of the standard inhibitor Baicalein with ΔG -7.36 kcal/mol. Docking results were further validated by machine learning. Linarin can be easily extracted from the Angiosperms and used as an herbal product to inhibit HPV E7 oncoprotein. The compounds identified here contribute to fascinating beginnings for further medical research and the development of therapeutic treatment." @default.
- W4385192794 created "2023-07-25" @default.
- W4385192794 creator A5018217697 @default.
- W4385192794 creator A5020661351 @default.
- W4385192794 creator A5033902472 @default.
- W4385192794 date "2023-05-12" @default.
- W4385192794 modified "2023-09-25" @default.
- W4385192794 title "Linarin as an Anti-Cancer Therapeutic: In-Silico and Machine Learning Approach for HPV" @default.
- W4385192794 cites W1618922586 @default.
- W4385192794 cites W1965806742 @default.
- W4385192794 cites W2016151398 @default.
- W4385192794 cites W2041176483 @default.
- W4385192794 cites W2089211835 @default.
- W4385192794 cites W2096541451 @default.
- W4385192794 cites W2098765233 @default.
- W4385192794 cites W2795665651 @default.
- W4385192794 cites W2800216153 @default.
- W4385192794 cites W3081735746 @default.
- W4385192794 doi "https://doi.org/10.1109/icacite57410.2023.10183190" @default.
- W4385192794 hasPublicationYear "2023" @default.
- W4385192794 type Work @default.
- W4385192794 citedByCount "0" @default.
- W4385192794 crossrefType "proceedings-article" @default.
- W4385192794 hasAuthorship W4385192794A5018217697 @default.
- W4385192794 hasAuthorship W4385192794A5020661351 @default.
- W4385192794 hasAuthorship W4385192794A5033902472 @default.
- W4385192794 hasConcept C103697762 @default.
- W4385192794 hasConcept C104317684 @default.
- W4385192794 hasConcept C1491633281 @default.
- W4385192794 hasConcept C159110408 @default.
- W4385192794 hasConcept C185592680 @default.
- W4385192794 hasConcept C2775905019 @default.
- W4385192794 hasConcept C2781466915 @default.
- W4385192794 hasConcept C29537977 @default.
- W4385192794 hasConcept C41685203 @default.
- W4385192794 hasConcept C502942594 @default.
- W4385192794 hasConcept C55493867 @default.
- W4385192794 hasConcept C70721500 @default.
- W4385192794 hasConcept C71924100 @default.
- W4385192794 hasConcept C74187038 @default.
- W4385192794 hasConcept C83258922 @default.
- W4385192794 hasConcept C86803240 @default.
- W4385192794 hasConcept C98274493 @default.
- W4385192794 hasConceptScore W4385192794C103697762 @default.
- W4385192794 hasConceptScore W4385192794C104317684 @default.
- W4385192794 hasConceptScore W4385192794C1491633281 @default.
- W4385192794 hasConceptScore W4385192794C159110408 @default.
- W4385192794 hasConceptScore W4385192794C185592680 @default.
- W4385192794 hasConceptScore W4385192794C2775905019 @default.
- W4385192794 hasConceptScore W4385192794C2781466915 @default.
- W4385192794 hasConceptScore W4385192794C29537977 @default.
- W4385192794 hasConceptScore W4385192794C41685203 @default.
- W4385192794 hasConceptScore W4385192794C502942594 @default.
- W4385192794 hasConceptScore W4385192794C55493867 @default.
- W4385192794 hasConceptScore W4385192794C70721500 @default.
- W4385192794 hasConceptScore W4385192794C71924100 @default.
- W4385192794 hasConceptScore W4385192794C74187038 @default.
- W4385192794 hasConceptScore W4385192794C83258922 @default.
- W4385192794 hasConceptScore W4385192794C86803240 @default.
- W4385192794 hasConceptScore W4385192794C98274493 @default.
- W4385192794 hasLocation W43851927941 @default.
- W4385192794 hasOpenAccess W4385192794 @default.
- W4385192794 hasPrimaryLocation W43851927941 @default.
- W4385192794 hasRelatedWork W1714666523 @default.
- W4385192794 hasRelatedWork W1974040436 @default.
- W4385192794 hasRelatedWork W2017773620 @default.
- W4385192794 hasRelatedWork W2064956914 @default.
- W4385192794 hasRelatedWork W3093985263 @default.
- W4385192794 hasRelatedWork W3122772507 @default.
- W4385192794 hasRelatedWork W3164503237 @default.
- W4385192794 hasRelatedWork W3207537951 @default.
- W4385192794 hasRelatedWork W4251172047 @default.
- W4385192794 hasRelatedWork W4362700983 @default.
- W4385192794 isParatext "false" @default.
- W4385192794 isRetracted "false" @default.
- W4385192794 workType "article" @default.