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- W4385194906 abstract "Background and Aim: Sarcopenia has been associated with poor survival in patients with cirrhosis. Nutrition may have direct influence on sarcopenia and functional status. There is limited data on nutritional management in cirrhosis with sarcopenia. We assessed the effects of nutritional therapy on sarcopenia in cirrhotic patients. Methods: A randomized controlled trial conducted in a tertiary care setting on patients of cirrhosis with sarcopenia who were randomized to nutritional therapy (group A: 30-35 kcal/kg/day and 1.0-1.5 gram of protein/kg/day) and no nutritional therapy (group B: diet as patients were taking before) for 6 months. Sarcopenia was diagnosed based on computerized tomography psoas muscle index (PMI), hand grip strength (HG) and gait velocity (GV). Primary endpoints were improvement or worsening in sarcopenia. Secondary end points were improvement of other nutritional parameters and liver functions. Results: 141 patients were randomized to group-A (n = 70, age 42.7±10.1yr, 58 men) and group-B (n = 71, age 42.1±9.8yr, 57 men). Baseline characteristics including age, body mass index (BMI), hemoglobin, mid arm circumference (MAC), hand grip, gait velocity and PMI were comparable in both the groups.Improvement in MAC (MAC 2.78±0.26 vs -2.13± 0.32; p=0.001), hand grip strength (HG 4.91±1.4 vs -3.1± 0.73; p= 0.001), gait velocity (GV 0.98±0.20 vs -0.74±0.32; p<0.01), PMI (PMI 3.5±0.24 vs -2.7 ±0.42; p<0.001) was higher in group A compared to group B at the end of study. Liver functions assessed by Child Turcotte Pugh and Model for end stage liver disease also significantly improved in group A compared to group B, p<0.001. Conclusion: Nutritional therapy is effective in the improvement of sarcopenia and liver function in cirrhosis." @default.
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- W4385194906 date "2023-01-01" @default.
- W4385194906 modified "2023-09-28" @default.
- W4385194906 title "Effects of Nutritional Therapy on Sarcopenia in Patients with Liver Cirrhosis- A Randomized Controlled Trial" @default.
- W4385194906 doi "https://doi.org/10.1016/j.jceh.2023.07.345" @default.
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