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- W4385196611 abstract "Background and Aim: The large number of chronic liver disease patients who are hospitalized have prior complications and on regular medications related to liver disease. In the present study, the complications such as ascites, hepatic encephalopathy and GI bleed were compared with outcome. Also, prior drug use such as UDCA, Rifaximin and beta blockers were compared with outcome. Methods: This was a prospective, observational study including consecutive 400 admitted patients of chronic liver disease. The primary endpoint of study was comparison of prior complications of chronic liver disease with outcome. The secondary endpoint was to assess the impact of medication prior to hospitalization on hospital outcome. Results: In the present study 85.8% of patients had one or more prior complications of chronic liver disease. The prior complication incidence rate was ascites (43.5%), jaundice (28.7%), UGI bleed (24.5%), HE (13.5%), AKI (4.2%), SBP (1.8%), HCC (1.2%) and LGI bleed (0.5%). Mortality rate in patients with prior ascites, jaundice, UGI bleed, HE, AKI and SBP was 25.3%, 43.5%, 21.4%, 31.5%, 23.5% and 14.3% respectively. The only statistical significance was seen in patients with jaundice (p= 0.001). In prior medication history, rifaximin was used in 55%, UDCA was used in 79.5% and beta blocker was used in 26% of patients. Mortality rate in patients with prior use of Rifaximin, UDCA and beta blocker was 25.9%, 30.8% and 22.1% respectively. Negative correlation was seen in patients using UDCA (p= 0.003). Conclusion: No significant correlation was seen with outcome when compared with prior complications and prior medication use in hospitalized CLD patients." @default.
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- W4385196611 date "2023-01-01" @default.
- W4385196611 modified "2023-09-27" @default.
- W4385196611 title "Prior complication and medications- Does it really have impact on outcome of chronic liver disease?" @default.
- W4385196611 doi "https://doi.org/10.1016/j.jceh.2023.07.307" @default.
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