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- W4385196688 abstract "Background and Aim: In India, estimated pooled prevalence among adults of NAFLD is 38.6%. NAFLD has been integrated in the National Program for Non- communicable Diseases (NP-NCD). It recommends a population-based screening tool- Community Based Assessment Checklist (CBAC) for screening NAFLD by ASHA workers. This study aimed to validate CBAC as a screening tool for NAFLD against FibroScan as the gold standard test. Methods: A diagnostic validation study, where 422 individuals of age 30 years from OPDs of various departments referred to undergo FibroScan examination were enrolled, and a pretested and predesigned questionnaire based on CBAC and Indian Diabetic Risk Score (IDRS) screening tools was administered. Patients with chronic liver disease of known etiology and/or significant alcohol intake were excluded. Study participants with Controlled Attenuated parameter (CAP) value 275 dB/m were diagnosed with NAFLD. Measures of diagnostic accuracy for CBAC scores were calculated and compared. Receiver Operating Characteristic (ROC) curve analysis of CBAC, IDRS were done using SPSS v.23.0. Results: The mean age of 422 study participants was 43± 11 years and 56.6% were males. As per FibroScan definition, 128 (30.3%) had NAFLD. Area under the Curve (AUC) of CBAC for predicting NAFLD was 0.65 (95% CI: 0.60- 0.70) with 60.9% (95% CI: 51.9- 69.4) sensitivity, 61.2% (95% CI: 55.4- 66.8) specificity at cut off >4 (Youden’s index, 0.22). ROC analysis revealed highest Youden’s Index of 0.25 for CBAC cut-off-4.5 ∼5. The AUC was better for IDRS, 0.67 (95% CI: 0.62- 0.72). Conclusion: The overall performance of suggested CBAC >4 for screening NAFLD is suboptimal. IDRS could potentially be a better screening tool for NAFLD. More studies with larger sample size are needed to validate and recalibrate CBAC and IDRS for screening of NAFLD." @default.
- W4385196688 created "2023-07-25" @default.
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- W4385196688 date "2023-01-01" @default.
- W4385196688 modified "2023-09-28" @default.
- W4385196688 title "Validation of Community Based Assessment Checklist (CBAC) as a Screening Tool for Non-alcoholic Fatty Liver Disease (NAFLD) Against FibroScan as a Gold Standard: A Diagnostic Validation Study" @default.
- W4385196688 doi "https://doi.org/10.1016/j.jceh.2023.07.174" @default.
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