Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385200280> ?p ?o ?g. }
- W4385200280 abstract "Abstract Cancer progression is enhanced by the interaction of programmed death-ligand 1 (PDL1), which is associated with inhibition of the immune response against tumors, and vascular endothelial growth factor (VEGF), which inhibits immune cell activity while inducing angiogenesis and proliferation of cancer cells. Dual inhibition of PDL1 and VEGF may therefore confer a synergistic anti-cancer therapeutic effect. We present a novel strategy for developing a therapeutic that simultaneously binds and inhibits both PDL1 and VEGF. We generated a bi-specific protein, designated DuRan-Bis, comprising a single chain variable fragment (scFv)-based inhibitor of PDL1 fused to an scFv-based inhibitor of VEGF, with the latter being attached to an Fc fragment. We found that DuRan-Bis binds to both PDL1 and VEGF with high affinity. Compared to treatments with mono-specific proteins, alone or in combination, the DuRan-Bis chimera showed superior inhibition of the proliferation of glioblastoma cells. In comparison to treatment with immune cells alone, a combination of immune cells with DuRan-Bis decreased the viability of head and neck cancer cells. To the best of our knowledge, this study is the first to use a single polypeptide chain scFv-scFv-Fc scaffold for engineering a high-affinity bi-specific inhibitor of PDL1 and VEGF." @default.
- W4385200280 created "2023-07-25" @default.
- W4385200280 creator A5008242831 @default.
- W4385200280 creator A5028992290 @default.
- W4385200280 creator A5036220892 @default.
- W4385200280 creator A5050029751 @default.
- W4385200280 creator A5062362384 @default.
- W4385200280 creator A5081303755 @default.
- W4385200280 date "2023-07-24" @default.
- W4385200280 modified "2023-09-25" @default.
- W4385200280 title "Developing a dual VEGF/PDL1 inhibitor based on high-affinity scFv heterodimers as an anti-cancer therapeutic strategy" @default.
- W4385200280 cites W1635229836 @default.
- W4385200280 cites W1848910860 @default.
- W4385200280 cites W1964871165 @default.
- W4385200280 cites W2017819764 @default.
- W4385200280 cites W2018295245 @default.
- W4385200280 cites W2019061836 @default.
- W4385200280 cites W2021855052 @default.
- W4385200280 cites W2032892351 @default.
- W4385200280 cites W2049424656 @default.
- W4385200280 cites W2080202443 @default.
- W4385200280 cites W2083983523 @default.
- W4385200280 cites W2124415048 @default.
- W4385200280 cites W2140088548 @default.
- W4385200280 cites W2140264799 @default.
- W4385200280 cites W2141247392 @default.
- W4385200280 cites W2201672580 @default.
- W4385200280 cites W2203631518 @default.
- W4385200280 cites W2233818050 @default.
- W4385200280 cites W2280336402 @default.
- W4385200280 cites W2292383635 @default.
- W4385200280 cites W2526473535 @default.
- W4385200280 cites W2554479252 @default.
- W4385200280 cites W2571138221 @default.
- W4385200280 cites W2599766179 @default.
- W4385200280 cites W2604441970 @default.
- W4385200280 cites W2610929033 @default.
- W4385200280 cites W2615165013 @default.
- W4385200280 cites W2734670400 @default.
- W4385200280 cites W2746541731 @default.
- W4385200280 cites W2747016053 @default.
- W4385200280 cites W2753065806 @default.
- W4385200280 cites W2769127959 @default.
- W4385200280 cites W2783703728 @default.
- W4385200280 cites W2784437331 @default.
- W4385200280 cites W2784605149 @default.
- W4385200280 cites W2804661897 @default.
- W4385200280 cites W2805354595 @default.
- W4385200280 cites W2887843032 @default.
- W4385200280 cites W2890963591 @default.
- W4385200280 cites W2891280779 @default.
- W4385200280 cites W2891760302 @default.
- W4385200280 cites W2893126573 @default.
- W4385200280 cites W2895772733 @default.
- W4385200280 cites W2905807945 @default.
- W4385200280 cites W2922021678 @default.
- W4385200280 cites W2925322150 @default.
- W4385200280 cites W2927269134 @default.
- W4385200280 cites W2941109595 @default.
- W4385200280 cites W2997135462 @default.
- W4385200280 cites W3009726125 @default.
- W4385200280 cites W3014255801 @default.
- W4385200280 cites W3023674145 @default.
- W4385200280 cites W3095448915 @default.
- W4385200280 cites W3106414058 @default.
- W4385200280 cites W3119778789 @default.
- W4385200280 cites W3162141400 @default.
- W4385200280 cites W3192568295 @default.
- W4385200280 cites W3212413144 @default.
- W4385200280 cites W4200389618 @default.
- W4385200280 cites W4241749643 @default.
- W4385200280 cites W4301391326 @default.
- W4385200280 doi "https://doi.org/10.1038/s41598-023-39076-8" @default.
- W4385200280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37488176" @default.
- W4385200280 hasPublicationYear "2023" @default.
- W4385200280 type Work @default.
- W4385200280 citedByCount "0" @default.
- W4385200280 crossrefType "journal-article" @default.
- W4385200280 hasAuthorship W4385200280A5008242831 @default.
- W4385200280 hasAuthorship W4385200280A5028992290 @default.
- W4385200280 hasAuthorship W4385200280A5036220892 @default.
- W4385200280 hasAuthorship W4385200280A5050029751 @default.
- W4385200280 hasAuthorship W4385200280A5062362384 @default.
- W4385200280 hasAuthorship W4385200280A5081303755 @default.
- W4385200280 hasBestOaLocation W43852002801 @default.
- W4385200280 hasConcept C121608353 @default.
- W4385200280 hasConcept C153911025 @default.
- W4385200280 hasConcept C159654299 @default.
- W4385200280 hasConcept C167734588 @default.
- W4385200280 hasConcept C185592680 @default.
- W4385200280 hasConcept C203014093 @default.
- W4385200280 hasConcept C2777025900 @default.
- W4385200280 hasConcept C2780394083 @default.
- W4385200280 hasConcept C502942594 @default.
- W4385200280 hasConcept C54355233 @default.
- W4385200280 hasConcept C86803240 @default.
- W4385200280 hasConcept C8891405 @default.
- W4385200280 hasConcept C96232424 @default.
- W4385200280 hasConceptScore W4385200280C121608353 @default.
- W4385200280 hasConceptScore W4385200280C153911025 @default.