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• W4385201129 abstract "Irreversible electroporation (IRE) is a promising nonthermal ablation technique that uses high-voltage electrical pulses to create permanent pores in the cell membrane of target tissue. Recently, endoscopic IRE with catheter-based electrodes has attracted significant attention as a potential alternative tool for gastrointestinal tumors, but it has been challenged owing to the limited electric field distribution in an in-plane electrode configuration, in which rectangular interdigitated electrodes (IDEs) are commonly used. Herein, we report an enhanced electrical injury in tissue using triangular IDEs that cause strong electric fields to be induced at the tip of the electrode fingers. A set of 10 pulses with a duration of 100 μs and a frequency of 1 Hz were delivered to the tissue, and a finite element method was used to calculate the electrical injury in the gastrointestinal model. The probability of cell death by electrical injury at the triangular IDEs increases by approximately 10 times compared to that of conventional rectangular IDEs at the same electrode distance. These results could potentially pave the way toward designing electrodes in catheter-based IRE devices." @default.
• W4385201129 created "2023-07-25" @default.
• W4385201129 creator A5017505838 @default.
• W4385201129 creator A5073216991 @default.
• W4385201129 date "2023-07-21" @default.
• W4385201129 modified "2023-09-28" @default.
• W4385201129 title "Enhanced Electrical Injury Using Triangular Interdigitated Electrodes for Catheter-Based Irreversible Electroporation" @default.
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• W4385201129 doi "https://doi.org/10.3390/app13148455" @default.
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