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- W4385201495 abstract "Abstract Habituation is the diminishing of a physiological response to a frequently repeated stimulus. In Aplysia , habituation to touch is mediated by the depression of the response to sensory neuron firing mediated by a decrease in transmitter release even after modest rates of action potential firing. This depression is not common among Aplysia synaptic connections suggesting the presence of a release apparatus specialized for this depression. This depression can be reversed through activation of protein kinase C and this is thought to underlie the behavior of dishabituation. We have previously noted that the calcium channel required for release, ApCa V 2, has many splice isoforms in Aplysia . We found that specific splice forms of ApCa V 2 and splice forms for interacting partners of ApCa V 2 are preferentially used in sensory neurons, consistent with a specialized release apparatus. However, we were not able to find a specific splice uniquely required for synaptic depression. The C-terminus of ApCa V 2 alpha1 subunit retains conserved binding sites for Aplysia rab-3 interacting molecule (ApRIM) and ApRIM-binding protein (ApRBP) and the C-terminus is required for full synaptic expression of ApCa V 2." @default.
- W4385201495 created "2023-07-25" @default.
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- W4385201495 date "2023-07-24" @default.
- W4385201495 modified "2023-09-23" @default.
- W4385201495 title "The role of specific isoforms of CaV2 and the common C-terminal of CaV2 in calcium channel function in sensory neurons of Aplysia" @default.
- W4385201495 doi "https://doi.org/10.21203/rs.3.rs-3084236/v1" @default.
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