Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385201910> ?p ?o ?g. }
- W4385201910 endingPage "1032" @default.
- W4385201910 startingPage "1032" @default.
- W4385201910 abstract "Several cues for a directional migration of colorectal cancer cells were identified as being crucial in tumor progression. However, galvanotaxis, the directional migration in direct-current electrical fields, has not been investigated so far. Therefore, we asked whether direct-current electrical fields could be used to mobilize colorectal cancer cells along field vectors. For this purpose, five patient-derived low-passage cell lines were exposed to field strengths of 150-250 V/m in vitro, and migration along the field vectors was investigated. To further study the role of voltage-gated calcium channels on galvanotaxis and intracellular signaling pathways that are associated with migration of colorectal cancer cells, the cultures were exposed to selective inhibitors. In three out of five colorectal cancer cell lines, we found a preferred cathodal migration. The cellular integrity of the cells was not impaired by exposure of the cells to the selected field strengths. Galvanotaxis was sensitive to inhibition of voltage-gated calcium channels. Furthermore, signaling pathways such as AKT and MEK, but not STAT3, were also found to contribute to galvanotaxis in our in vitro model system. Overall, we identify electrical fields as an important contributor to the directional migration of colorectal cancer cells." @default.
- W4385201910 created "2023-07-25" @default.
- W4385201910 creator A5008811271 @default.
- W4385201910 creator A5009941211 @default.
- W4385201910 creator A5010783656 @default.
- W4385201910 creator A5018385181 @default.
- W4385201910 creator A5019793360 @default.
- W4385201910 creator A5025055846 @default.
- W4385201910 creator A5048082682 @default.
- W4385201910 creator A5080295380 @default.
- W4385201910 date "2023-07-22" @default.
- W4385201910 modified "2023-10-14" @default.
- W4385201910 title "Direct-Current Electrical Field Stimulation of Patient-Derived Colorectal Cancer Cells" @default.
- W4385201910 cites W1569818199 @default.
- W4385201910 cites W1870243448 @default.
- W4385201910 cites W1923609236 @default.
- W4385201910 cites W1926562587 @default.
- W4385201910 cites W1978609960 @default.
- W4385201910 cites W1981683060 @default.
- W4385201910 cites W1994272521 @default.
- W4385201910 cites W1997862458 @default.
- W4385201910 cites W2003904720 @default.
- W4385201910 cites W2004668907 @default.
- W4385201910 cites W2015955448 @default.
- W4385201910 cites W2021350067 @default.
- W4385201910 cites W2027428986 @default.
- W4385201910 cites W2041624941 @default.
- W4385201910 cites W2062390698 @default.
- W4385201910 cites W2063627242 @default.
- W4385201910 cites W2065071281 @default.
- W4385201910 cites W2078739109 @default.
- W4385201910 cites W2079356525 @default.
- W4385201910 cites W2100384057 @default.
- W4385201910 cites W2116719283 @default.
- W4385201910 cites W2117497402 @default.
- W4385201910 cites W2123560650 @default.
- W4385201910 cites W2126548492 @default.
- W4385201910 cites W2129465437 @default.
- W4385201910 cites W2140156658 @default.
- W4385201910 cites W2168449130 @default.
- W4385201910 cites W2170895173 @default.
- W4385201910 cites W2254298611 @default.
- W4385201910 cites W2302003756 @default.
- W4385201910 cites W2316911260 @default.
- W4385201910 cites W2338439678 @default.
- W4385201910 cites W2410855711 @default.
- W4385201910 cites W2418700376 @default.
- W4385201910 cites W2480131545 @default.
- W4385201910 cites W2561650646 @default.
- W4385201910 cites W2567906836 @default.
- W4385201910 cites W2598448675 @default.
- W4385201910 cites W2607636199 @default.
- W4385201910 cites W2610462629 @default.
- W4385201910 cites W2756874414 @default.
- W4385201910 cites W2795319742 @default.
- W4385201910 cites W2801092547 @default.
- W4385201910 cites W2913437602 @default.
- W4385201910 cites W2924438894 @default.
- W4385201910 cites W2937412486 @default.
- W4385201910 cites W2952889298 @default.
- W4385201910 cites W2965087682 @default.
- W4385201910 cites W2965163995 @default.
- W4385201910 cites W2967377138 @default.
- W4385201910 cites W2971543513 @default.
- W4385201910 cites W2972778323 @default.
- W4385201910 cites W2974072826 @default.
- W4385201910 cites W2979684317 @default.
- W4385201910 cites W2990089961 @default.
- W4385201910 cites W2993524467 @default.
- W4385201910 cites W3000572928 @default.
- W4385201910 cites W3029612688 @default.
- W4385201910 cites W3039153379 @default.
- W4385201910 cites W3041698669 @default.
- W4385201910 cites W3091282326 @default.
- W4385201910 cites W3095674084 @default.
- W4385201910 cites W3161590961 @default.
- W4385201910 cites W3183115067 @default.
- W4385201910 cites W3190885108 @default.
- W4385201910 cites W3215545453 @default.
- W4385201910 cites W4206841660 @default.
- W4385201910 cites W4214924743 @default.
- W4385201910 cites W4224039009 @default.
- W4385201910 cites W4281252632 @default.
- W4385201910 cites W4316806105 @default.
- W4385201910 cites W4360608851 @default.
- W4385201910 cites W4376224597 @default.
- W4385201910 cites W89255747 @default.
- W4385201910 cites W2947001278 @default.
- W4385201910 doi "https://doi.org/10.3390/biology12071032" @default.
- W4385201910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37508461" @default.
- W4385201910 hasPublicationYear "2023" @default.
- W4385201910 type Work @default.
- W4385201910 citedByCount "0" @default.
- W4385201910 crossrefType "journal-article" @default.
- W4385201910 hasAuthorship W4385201910A5008811271 @default.
- W4385201910 hasAuthorship W4385201910A5009941211 @default.
- W4385201910 hasAuthorship W4385201910A5010783656 @default.
- W4385201910 hasAuthorship W4385201910A5018385181 @default.