Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385202210> ?p ?o ?g. }
- W4385202210 endingPage "1035" @default.
- W4385202210 startingPage "1035" @default.
- W4385202210 abstract "Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a rare but severe adverse effect that can occur as a result of bisphosphonate treatment. This study aimed to examine the relationship between PPARγ and PPARGC1A polymorphisms and the BRONJ development in female osteoporosis patients undergoing bisphosphonate treatment. We prospectively conducted this nested case-control study at the Ewha Womans University Mokdong Hospital between 2014 and 2018. We assessed five single-nucleotide polymorphisms (SNPs) of PPARγ and six SNPs of PPARGC1A and performed a multivariable logistic regression analysis to determine the independent risk factors for developing BRONJ. There were a total of 123 patients included in this study and 56 patients (45.5%) developed BRONJ. In the univariate analysis, PPARGC1A rs2946385 and rs10020457 polymorphisms were significantly associated with BRONJ (p = 0.034, p = 0.020, respectively), although the results were not statistically significant in the multivariable analysis. Patients with the combined genotypes of GG in both PPARγ rs1151999 and PPARGC1A rs2946385 showed a 3.03-fold higher risk of BRONJ compared to individuals with other genotype combinations after adjusting for confounders (95% confidence interval (CI): 1.01-9.11). Old age (≥70 years) and duration of bisphosphonate use (≥60 months) increased the risk of BRONJ. The area under the receiver operating characteristic curve for the predicted probability was 0.78 (95% CI: 0.69-0.87, p < 0.001), demonstrating a satisfactory level of discriminatory power. Our study elucidated that PPARγ and PPARGC1A polymorphisms were interactively associated with BRONJ development. These results have potential implications for tailoring personalized treatments for females undergoing bisphosphonate therapy for osteoporosis." @default.
- W4385202210 created "2023-07-25" @default.
- W4385202210 creator A5013866618 @default.
- W4385202210 creator A5025221592 @default.
- W4385202210 creator A5051251200 @default.
- W4385202210 creator A5080970990 @default.
- W4385202210 creator A5084669649 @default.
- W4385202210 date "2023-07-21" @default.
- W4385202210 modified "2023-09-30" @default.
- W4385202210 title "Interactive Associations between PPARγ and PPARGC1A and Bisphosphonate-Related Osteonecrosis of the Jaw in Patients with Osteoporosis" @default.
- W4385202210 cites W1508834706 @default.
- W4385202210 cites W1524115663 @default.
- W4385202210 cites W1718065612 @default.
- W4385202210 cites W1957467225 @default.
- W4385202210 cites W1976711506 @default.
- W4385202210 cites W1984668213 @default.
- W4385202210 cites W1992150557 @default.
- W4385202210 cites W1994799035 @default.
- W4385202210 cites W1995808879 @default.
- W4385202210 cites W1996514596 @default.
- W4385202210 cites W1998660018 @default.
- W4385202210 cites W2007638378 @default.
- W4385202210 cites W2014161780 @default.
- W4385202210 cites W2033471620 @default.
- W4385202210 cites W2052046366 @default.
- W4385202210 cites W2058889454 @default.
- W4385202210 cites W2068522538 @default.
- W4385202210 cites W2074739776 @default.
- W4385202210 cites W2084311496 @default.
- W4385202210 cites W2084493261 @default.
- W4385202210 cites W2090198447 @default.
- W4385202210 cites W2097511872 @default.
- W4385202210 cites W2102176445 @default.
- W4385202210 cites W2106996732 @default.
- W4385202210 cites W2107208293 @default.
- W4385202210 cites W2110849113 @default.
- W4385202210 cites W2112873139 @default.
- W4385202210 cites W2116822087 @default.
- W4385202210 cites W2123262074 @default.
- W4385202210 cites W2124260947 @default.
- W4385202210 cites W2128613170 @default.
- W4385202210 cites W2145968349 @default.
- W4385202210 cites W2157222091 @default.
- W4385202210 cites W2158875435 @default.
- W4385202210 cites W2160102488 @default.
- W4385202210 cites W2168892366 @default.
- W4385202210 cites W2169512870 @default.
- W4385202210 cites W2195359644 @default.
- W4385202210 cites W2472459469 @default.
- W4385202210 cites W2570800839 @default.
- W4385202210 cites W2590873453 @default.
- W4385202210 cites W2626877417 @default.
- W4385202210 cites W2765155031 @default.
- W4385202210 cites W2884426132 @default.
- W4385202210 cites W2887180819 @default.
- W4385202210 cites W2936833997 @default.
- W4385202210 cites W2941292574 @default.
- W4385202210 cites W2945353632 @default.
- W4385202210 cites W2969788515 @default.
- W4385202210 cites W3047831418 @default.
- W4385202210 cites W3110629205 @default.
- W4385202210 cites W3138272350 @default.
- W4385202210 cites W3158777904 @default.
- W4385202210 cites W4313396054 @default.
- W4385202210 cites W4362619810 @default.
- W4385202210 doi "https://doi.org/10.3390/ph16071035" @default.
- W4385202210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37513946" @default.
- W4385202210 hasPublicationYear "2023" @default.
- W4385202210 type Work @default.
- W4385202210 citedByCount "0" @default.
- W4385202210 crossrefType "journal-article" @default.
- W4385202210 hasAuthorship W4385202210A5013866618 @default.
- W4385202210 hasAuthorship W4385202210A5025221592 @default.
- W4385202210 hasAuthorship W4385202210A5051251200 @default.
- W4385202210 hasAuthorship W4385202210A5080970990 @default.
- W4385202210 hasAuthorship W4385202210A5084669649 @default.
- W4385202210 hasBestOaLocation W43852022101 @default.
- W4385202210 hasConcept C104317684 @default.
- W4385202210 hasConcept C126322002 @default.
- W4385202210 hasConcept C135763542 @default.
- W4385202210 hasConcept C143998085 @default.
- W4385202210 hasConcept C144301174 @default.
- W4385202210 hasConcept C151956035 @default.
- W4385202210 hasConcept C153209595 @default.
- W4385202210 hasConcept C2776541429 @default.
- W4385202210 hasConcept C2777251235 @default.
- W4385202210 hasConcept C2777556957 @default.
- W4385202210 hasConcept C2779921893 @default.
- W4385202210 hasConcept C38180746 @default.
- W4385202210 hasConcept C44249647 @default.
- W4385202210 hasConcept C55493867 @default.
- W4385202210 hasConcept C71924100 @default.
- W4385202210 hasConcept C77350462 @default.
- W4385202210 hasConcept C86803240 @default.
- W4385202210 hasConceptScore W4385202210C104317684 @default.
- W4385202210 hasConceptScore W4385202210C126322002 @default.
- W4385202210 hasConceptScore W4385202210C135763542 @default.
- W4385202210 hasConceptScore W4385202210C143998085 @default.