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- W4385212591 endingPage "2085" @default.
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- W4385212591 abstract "Lung cancer is the leading cause of cancer-related deaths in Europe, with low survival rates primarily due to late-stage diagnosis. Early detection can significantly improve survival rates, but lung cancer screening is not currently implemented in Italy. Many countries have implemented lung cancer screening programs for high-risk populations, with studies showing a reduction in mortality. This review aimed to identify key areas for establishing a lung cancer screening program in Italy. A literature search was conducted in October 2022, using the PubMed and Scopus databases. Items of interest included updated evidence, approaches used in other countries, enrollment and eligibility criteria, models, cost-effectiveness studies, and smoking cessation programs. A literature search yielded 61 scientific papers, highlighting the effectiveness of low-dose computed tomography (LDCT) screening in reducing mortality among high-risk populations. The National Lung Screening Trial (NLST) in the United States demonstrated a 20% reduction in lung cancer mortality with LDCT, and other trials confirmed its potential to reduce mortality by up to 39% and detect early-stage cancers. However, false-positive results and associated harm were concerns. Economic evaluations generally supported the cost-effectiveness of LDCT screening, especially when combined with smoking cessation interventions for individuals aged 55 to 75 with a significant smoking history. Implementing a screening program in Italy requires the careful consideration of optimal strategies, population selection, result management, and the integration of smoking cessation. Resource limitations and tailored interventions for subpopulations with low-risk perception and non-adherence rates should be addressed with multidisciplinary expertise." @default.
- W4385212591 created "2023-07-25" @default.
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- W4385212591 date "2023-07-21" @default.
- W4385212591 modified "2023-10-11" @default.
- W4385212591 title "Systematic Review of Lung Cancer Screening: Advancements and Strategies for Implementation" @default.
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- W4385212591 doi "https://doi.org/10.3390/healthcare11142085" @default.
- W4385212591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37510525" @default.
- W4385212591 hasPublicationYear "2023" @default.
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