FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385213735> ?p ?o ?g. }

• W4385213735 endingPage "112029" @default.
• W4385213735 startingPage "112029" @default.
• W4385213735 abstract "Diabetes mellitus is a metabolic disease that is characterized by elevated blood sugar. Although glucagon-like peptide-1 receptor agonists (GLP-1RA) lower blood glucose in a glucose-dependent manner, most of them are macromolecule polypeptides. Macromolecular peptides are relatively expensive and inconvenient compared with small molecules. Therefore, this study sought to identify the small molecules binding to GLP-1R via cell membrane chromatography (CMC), confirm their agonistic activity, and further study its beneficial effects in a mouse model of type 2 diabetes mellitus (T2DM) induced by a combination of high-fat diet and streptozotocin. We used CMC, calcium imaging and molecular docking techniques to screen and identify the potential small molecule Schisandrin B (Sch B), which exhibits a strong binding effect to GLP-1R, from the small molecule library of traditional Chinese medicine. Through in-vitro experiments, we found that Sch B stimulated insulin secretion in β-TC-6 cells, while GLP-1R antagonist Exendin9-39, adenylate cyclase inhibitor SQ22536, and protein kinase A (PKA) inhibitor H89 could significantly inhibit the insulin secretion induced by Sch B. In vivo, Sch B significantly improved fasting blood glucose levels, intraperitoneal glucose tolerance test damage, and the status of pancreatic tissue damage, and reduced serum insulin levels, total cholesterol, triglyceride and low density lipoprotein in T2DM mice. These results indicate that Sch B alleviates T2DM by promoting insulin release through the GLP-1R/cAMP/PKA signaling pathway, suggesting that Sch B may be a potential GLP-1RA, which is expected to provide a new therapeutic strategy for the prevention and treatment of T2DM." @default.
• W4385213735 created "2023-07-25" @default.
• W4385213735 creator A5003910460 @default.
• W4385213735 creator A5007991562 @default.
• W4385213735 creator A5016557386 @default.
• W4385213735 creator A5032364203 @default.
• W4385213735 creator A5033317985 @default.
• W4385213735 creator A5033780495 @default.
• W4385213735 creator A5035823155 @default.
• W4385213735 creator A5041255632 @default.
• W4385213735 creator A5045545412 @default.
• W4385213735 creator A5058347981 @default.
• W4385213735 creator A5078244947 @default.
• W4385213735 creator A5081868823 @default.
• W4385213735 creator A5088579301 @default.
• W4385213735 date "2023-11-01" @default.
• W4385213735 modified "2023-10-10" @default.
• W4385213735 title "Schisandrin B, a potential GLP-1R agonist, exerts anti-diabetic effects by stimulating insulin secretion" @default.
• W4385213735 cites W1966041826 @default.
• W4385213735 cites W1975318062 @default.
• W4385213735 cites W1982077841 @default.
• W4385213735 cites W1983113419 @default.
• W4385213735 cites W1997556506 @default.
• W4385213735 cites W2002939114 @default.
• W4385213735 cites W2005283509 @default.
• W4385213735 cites W2009897648 @default.
• W4385213735 cites W2013082477 @default.
• W4385213735 cites W2018904710 @default.
• W4385213735 cites W2022718658 @default.
• W4385213735 cites W2023556678 @default.
• W4385213735 cites W2033362878 @default.
• W4385213735 cites W2043562898 @default.
• W4385213735 cites W2045396773 @default.
• W4385213735 cites W2085073123 @default.
• W4385213735 cites W2091942573 @default.
• W4385213735 cites W2092557995 @default.
• W4385213735 cites W2093088114 @default.
• W4385213735 cites W2138024058 @default.
• W4385213735 cites W2142458050 @default.
• W4385213735 cites W2145736355 @default.
• W4385213735 cites W2145824107 @default.
• W4385213735 cites W2304013040 @default.
• W4385213735 cites W2343777255 @default.
• W4385213735 cites W2565013872 @default.
• W4385213735 cites W2593117517 @default.
• W4385213735 cites W2772539661 @default.
• W4385213735 cites W2774743973 @default.
• W4385213735 cites W2795481136 @default.
• W4385213735 cites W3000083217 @default.
• W4385213735 cites W3095909321 @default.
• W4385213735 cites W3110313641 @default.
• W4385213735 cites W4214764520 @default.
• W4385213735 cites W4285087957 @default.
• W4385213735 cites W4298111265 @default.
• W4385213735 cites W4322388712 @default.
• W4385213735 doi "https://doi.org/10.1016/j.mce.2023.112029" @default.
• W4385213735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37495090" @default.
• W4385213735 hasPublicationYear "2023" @default.
• W4385213735 type Work @default.
• W4385213735 citedByCount "0" @default.
• W4385213735 crossrefType "journal-article" @default.
• W4385213735 hasAuthorship W4385213735A5003910460 @default.
• W4385213735 hasAuthorship W4385213735A5007991562 @default.
• W4385213735 hasAuthorship W4385213735A5016557386 @default.
• W4385213735 hasAuthorship W4385213735A5032364203 @default.
• W4385213735 hasAuthorship W4385213735A5033317985 @default.
• W4385213735 hasAuthorship W4385213735A5033780495 @default.
• W4385213735 hasAuthorship W4385213735A5035823155 @default.
• W4385213735 hasAuthorship W4385213735A5041255632 @default.
• W4385213735 hasAuthorship W4385213735A5045545412 @default.
• W4385213735 hasAuthorship W4385213735A5058347981 @default.
• W4385213735 hasAuthorship W4385213735A5078244947 @default.
• W4385213735 hasAuthorship W4385213735A5081868823 @default.
• W4385213735 hasAuthorship W4385213735A5088579301 @default.
• W4385213735 hasConcept C112446052 @default.
• W4385213735 hasConcept C126322002 @default.
• W4385213735 hasConcept C134018914 @default.
• W4385213735 hasConcept C185592680 @default.
• W4385213735 hasConcept C2777391703 @default.
• W4385213735 hasConcept C2778163477 @default.
• W4385213735 hasConcept C2778913445 @default.
• W4385213735 hasConcept C2779306644 @default.
• W4385213735 hasConcept C71924100 @default.
• W4385213735 hasConcept C86803240 @default.
• W4385213735 hasConcept C98274493 @default.
• W4385213735 hasConcept C98335778 @default.
• W4385213735 hasConceptScore W4385213735C112446052 @default.
• W4385213735 hasConceptScore W4385213735C126322002 @default.
• W4385213735 hasConceptScore W4385213735C134018914 @default.
• W4385213735 hasConceptScore W4385213735C185592680 @default.
• W4385213735 hasConceptScore W4385213735C2777391703 @default.
• W4385213735 hasConceptScore W4385213735C2778163477 @default.
• W4385213735 hasConceptScore W4385213735C2778913445 @default.
• W4385213735 hasConceptScore W4385213735C2779306644 @default.
• W4385213735 hasConceptScore W4385213735C71924100 @default.
• W4385213735 hasConceptScore W4385213735C86803240 @default.
• W4385213735 hasConceptScore W4385213735C98274493 @default.
• W4385213735 hasConceptScore W4385213735C98335778 @default.

• next