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- W4385217811 endingPage "101800" @default.
- W4385217811 startingPage "101800" @default.
- W4385217811 abstract "The defense against infectious diseases, either through natural immunity or after vaccinations, relies on the generation and maintenance of protective T cell memory. Naïve T cells are at the center of memory T cell generation during primary responses. Upon activation, they undergo a complex, highly regulated differentiation process towards different functional states. Naïve T cells maintained into older age have undergone epigenetic adaptations that influence their fate decisions during differentiation. We review age-sensitive, molecular pathways and gene regulatory networks that bias naïve T cell differentiation towards effector cell generation at the expense of memory and Tfh cells. As a result, T cell differentiation in older adults is associated with release of bioactive waste products into the microenvironment, higher stress sensitivity as well as skewing towards pro-inflammatory signatures and shorter life spans. These maladaptations not only contribute to poor vaccine responses in older adults but also fuel a more inflammatory state." @default.
- W4385217811 created "2023-07-25" @default.
- W4385217811 creator A5000208713 @default.
- W4385217811 creator A5002355766 @default.
- W4385217811 creator A5006681271 @default.
- W4385217811 creator A5056587089 @default.
- W4385217811 creator A5058162689 @default.
- W4385217811 date "2023-09-01" @default.
- W4385217811 modified "2023-10-16" @default.
- W4385217811 title "T cell fate decisions during memory cell generation with aging" @default.
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