FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385223934> ?p ?o ?g. }

• W4385223934 abstract "Microenvironmental factors, including microbe-induced inflammation and immune-checkpoint proteins that modulate immune cells have been associated with both cervical insufficiency and preterm delivery. These factors are incompletely understood. This study aimed to explore and compare interactions among microbiome and inflammatory factors, such as cytokines and immune-checkpoint proteins, in patients with cervical insufficiency and preterm birth. In particular, factors related to predicting preterm birth were identified and the performance of the combination of these factors was evaluated.A total of 220 swab samples from 110 pregnant women, prospectively recruited at the High-Risk Maternal Neonatal Intensive Care Center, were collected between February 2020 and March 2021. This study included 63 patients with cervical insufficiency receiving cerclage and 47 control participants. Endo- and exocervical swabs and fluids were collected simultaneously. Shotgun metagenomic sequencing for the microbiome and the measurement of 34 immune-checkpoint proteins and inflammatory cytokines were performed.First, we demonstrated that immune-checkpoint proteins, the key immune-regulatory molecules, could be measured in endocervical and exocervical samples. Secondly, we identified significantly different microenvironments in cervical insufficiency and preterm birth, with precise cervical locations, to provide information about practically useful cervical locations in clinical settings. Finally, the presence of Moraxella osloensis (odds ratio = 14.785; P = 0.037) and chemokine CC motif ligand 2 levels higher than 73 pg/mL (odds ratio = 40.049; P = 0.005) in endocervical samples were associated with preterm birth. Combining M. osloensis and chemokine CC motif ligand 2 yielded excellent performance for predicting preterm birth (area under the receiver operating characteristic curve = 0.846, 95% confidence interval = 0.733-0.925).Multiple relationships between microbiomes, immune-checkpoint proteins, and inflammatory cytokines in the cervical microenvironment were identified. We focus on these factors to aid in the comprehensive understanding and therapeutic modulation of local microbial and immunologic compositions for the management of cervical insufficiency and preterm birth." @default.
• W4385223934 created "2023-07-25" @default.
• W4385223934 creator A5004916027 @default.
• W4385223934 creator A5011622536 @default.
• W4385223934 creator A5012590234 @default.
• W4385223934 creator A5012699792 @default.
• W4385223934 creator A5026109191 @default.
• W4385223934 creator A5052491510 @default.
• W4385223934 creator A5064656362 @default.
• W4385223934 creator A5064820790 @default.
• W4385223934 creator A5073372445 @default.
• W4385223934 date "2023-07-24" @default.
• W4385223934 modified "2023-10-14" @default.
• W4385223934 title "Immune-checkpoint proteins, cytokines, and microbiome impact on patients with cervical insufficiency and preterm birth" @default.
• W4385223934 cites W1563950821 @default.
• W4385223934 cites W1617495083 @default.
• W4385223934 cites W167194902 @default.
• W4385223934 cites W1942290733 @default.
• W4385223934 cites W1968791512 @default.
• W4385223934 cites W1975755498 @default.
• W4385223934 cites W1993293104 @default.
• W4385223934 cites W1993745678 @default.
• W4385223934 cites W1996217426 @default.
• W4385223934 cites W1996412164 @default.
• W4385223934 cites W2005149421 @default.
• W4385223934 cites W2010101647 @default.
• W4385223934 cites W2098251774 @default.
• W4385223934 cites W2103865039 @default.
• W4385223934 cites W2122833277 @default.
• W4385223934 cites W2167942713 @default.
• W4385223934 cites W2186430820 @default.
• W4385223934 cites W2515236995 @default.
• W4385223934 cites W2532277268 @default.
• W4385223934 cites W2555667037 @default.
• W4385223934 cites W2560382387 @default.
• W4385223934 cites W2727368566 @default.
• W4385223934 cites W2735043467 @default.
• W4385223934 cites W2735765442 @default.
• W4385223934 cites W2749272636 @default.
• W4385223934 cites W2761875562 @default.
• W4385223934 cites W2781957043 @default.
• W4385223934 cites W2806769319 @default.
• W4385223934 cites W2912182143 @default.
• W4385223934 cites W2921329806 @default.
• W4385223934 cites W2924015319 @default.
• W4385223934 cites W2931032704 @default.
• W4385223934 cites W2947640277 @default.
• W4385223934 cites W2968446013 @default.
• W4385223934 cites W2990157180 @default.
• W4385223934 cites W2997381078 @default.
• W4385223934 cites W2999682620 @default.
• W4385223934 cites W3023807845 @default.
• W4385223934 cites W3046931682 @default.
• W4385223934 cites W3087119991 @default.
• W4385223934 cites W3151036224 @default.
• W4385223934 cites W3206592156 @default.
• W4385223934 cites W4205495272 @default.
• W4385223934 cites W4210468600 @default.
• W4385223934 cites W4212959036 @default.
• W4385223934 cites W4280535184 @default.
• W4385223934 cites W4280538678 @default.
• W4385223934 cites W4298004447 @default.
• W4385223934 cites W4313595760 @default.
• W4385223934 cites W4376595483 @default.
• W4385223934 cites W2001512169 @default.
• W4385223934 doi "https://doi.org/10.3389/fimmu.2023.1228647" @default.
• W4385223934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37554329" @default.
• W4385223934 hasPublicationYear "2023" @default.
• W4385223934 type Work @default.
• W4385223934 citedByCount "0" @default.
• W4385223934 crossrefType "journal-article" @default.
• W4385223934 hasAuthorship W4385223934A5004916027 @default.
• W4385223934 hasAuthorship W4385223934A5011622536 @default.
• W4385223934 hasAuthorship W4385223934A5012590234 @default.
• W4385223934 hasAuthorship W4385223934A5012699792 @default.
• W4385223934 hasAuthorship W4385223934A5026109191 @default.
• W4385223934 hasAuthorship W4385223934A5052491510 @default.
• W4385223934 hasAuthorship W4385223934A5064656362 @default.
• W4385223934 hasAuthorship W4385223934A5064820790 @default.
• W4385223934 hasAuthorship W4385223934A5073372445 @default.
• W4385223934 hasBestOaLocation W43852239341 @default.
• W4385223934 hasConcept C121608353 @default.
• W4385223934 hasConcept C126322002 @default.
• W4385223934 hasConcept C13373296 @default.
• W4385223934 hasConcept C143121216 @default.
• W4385223934 hasConcept C156957248 @default.
• W4385223934 hasConcept C164027704 @default.
• W4385223934 hasConcept C203014093 @default.
• W4385223934 hasConcept C2776914184 @default.
• W4385223934 hasConcept C2777740455 @default.
• W4385223934 hasConcept C2779234561 @default.
• W4385223934 hasConcept C2910530332 @default.
• W4385223934 hasConcept C54355233 @default.
• W4385223934 hasConcept C60644358 @default.
• W4385223934 hasConcept C71924100 @default.
• W4385223934 hasConcept C86803240 @default.
• W4385223934 hasConcept C8891405 @default.
• W4385223934 hasConceptScore W4385223934C121608353 @default.
• W4385223934 hasConceptScore W4385223934C126322002 @default.
• W4385223934 hasConceptScore W4385223934C13373296 @default.

• next