FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385225535> ?p ?o ?g. }

• W4385225535 endingPage "1031" @default.
• W4385225535 startingPage "1031" @default.
• W4385225535 abstract "Doxorubicin (DOX) is commonly used in several chemotherapies to treat various cancers, but it is known to cause cardiotoxicity and cardiac symptoms. Autonomic dysfunction is thought to contribute to the cardiotoxic effects of DOX, but the specific dose required to disrupt homeostatic processes is still unclear and is influenced by numerous factors. This study aimed to investigate how the DOX dosage affects autonomic function and physiological parameters, to elucidate the neurocardiac mechanisms underlying the observed cardiovascular side effects. Wistar rats were treated with DOX for four weeks and divided into three dosing groups: DOX8 (2 mg/kg/week), DOX16 (4 mg/kg/week), and DOX20 (5 mg/kg/week). A control group received NaCl 0.9% saline (1 mL/kg/week). In an acute experiment, we recorded blood pressure (BP), electrocardiogram, heart rate (HR), and respiratory rate (RF). Baroreflex gain and chemoreflex sensitivity were calculated, and cardiac tissue was analyzed with picrosirius histochemistry to measure collagen content. Our results showed that the LF/HF ratio, indicative of autonomic activity, was altered along with hypotension and bradycardia at a cumulative DOX dose threshold of 16 mg/kg. We observed a positive correlation between DOX dose and BP, HR, urinary norepinephrine, LF/HF ratio, and fibrotic heart area. Lower LF/HF ratios were associated with high DOX doses, reflecting drug-induced impairment of autonomic control of HR. This study provides valuable insights into the dose-dependent effects of DOX on physiological parameters and the development of cardiovascular dysfunction. These findings are critical, which is important for optimizing the management and therapeutic strategies for patients undergoing DOX-based chemotherapy." @default.
• W4385225535 created "2023-07-25" @default.
• W4385225535 creator A5042656237 @default.
• W4385225535 creator A5060045444 @default.
• W4385225535 creator A5070320283 @default.
• W4385225535 creator A5070797410 @default.
• W4385225535 creator A5080122735 @default.
• W4385225535 date "2023-07-22" @default.
• W4385225535 modified "2023-10-14" @default.
• W4385225535 title "Doxorubicin Dose-Dependent Impact on Physiological Balance—A Holistic Approach in a Rat Model" @default.
• W4385225535 cites W1264889757 @default.
• W4385225535 cites W1595453200 @default.
• W4385225535 cites W1828224642 @default.
• W4385225535 cites W1909516796 @default.
• W4385225535 cites W1979212156 @default.
• W4385225535 cites W1987593270 @default.
• W4385225535 cites W1988632535 @default.
• W4385225535 cites W1990044317 @default.
• W4385225535 cites W1998528619 @default.
• W4385225535 cites W2005408885 @default.
• W4385225535 cites W2006196877 @default.
• W4385225535 cites W2012743897 @default.
• W4385225535 cites W2017331060 @default.
• W4385225535 cites W2025083720 @default.
• W4385225535 cites W2028765929 @default.
• W4385225535 cites W2033286243 @default.
• W4385225535 cites W2048105612 @default.
• W4385225535 cites W2050890249 @default.
• W4385225535 cites W2055502077 @default.
• W4385225535 cites W2058286711 @default.
• W4385225535 cites W2076504017 @default.
• W4385225535 cites W2084304742 @default.
• W4385225535 cites W2085163888 @default.
• W4385225535 cites W2085329742 @default.
• W4385225535 cites W2086505212 @default.
• W4385225535 cites W2089609098 @default.
• W4385225535 cites W2112569130 @default.
• W4385225535 cites W2133589238 @default.
• W4385225535 cites W2140182328 @default.
• W4385225535 cites W2153778647 @default.
• W4385225535 cites W2164132423 @default.
• W4385225535 cites W2262531539 @default.
• W4385225535 cites W2296878578 @default.
• W4385225535 cites W2343786611 @default.
• W4385225535 cites W2424680180 @default.
• W4385225535 cites W2508734629 @default.
• W4385225535 cites W2601265260 @default.
• W4385225535 cites W2736828995 @default.
• W4385225535 cites W2750510341 @default.
• W4385225535 cites W2764070635 @default.
• W4385225535 cites W2792351106 @default.
• W4385225535 cites W2800400752 @default.
• W4385225535 cites W2802346111 @default.
• W4385225535 cites W2890176306 @default.
• W4385225535 cites W2896467585 @default.
• W4385225535 cites W2916149962 @default.
• W4385225535 cites W3003668679 @default.
• W4385225535 cites W3019238719 @default.
• W4385225535 cites W3127166110 @default.
• W4385225535 cites W3160301529 @default.
• W4385225535 cites W3167466362 @default.
• W4385225535 cites W3197359597 @default.
• W4385225535 cites W3217241629 @default.
• W4385225535 cites W4220715245 @default.
• W4385225535 cites W4248511192 @default.
• W4385225535 cites W4251299311 @default.
• W4385225535 cites W4293859180 @default.
• W4385225535 cites W4294607415 @default.
• W4385225535 cites W4296622891 @default.
• W4385225535 cites W4312861576 @default.
• W4385225535 cites W4323318143 @default.
• W4385225535 cites W4323362512 @default.
• W4385225535 cites W4324142686 @default.
• W4385225535 doi "https://doi.org/10.3390/biology12071031" @default.
• W4385225535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37508460" @default.
• W4385225535 hasPublicationYear "2023" @default.
• W4385225535 type Work @default.
• W4385225535 citedByCount "0" @default.
• W4385225535 crossrefType "journal-article" @default.
• W4385225535 hasAuthorship W4385225535A5042656237 @default.
• W4385225535 hasAuthorship W4385225535A5060045444 @default.
• W4385225535 hasAuthorship W4385225535A5070320283 @default.
• W4385225535 hasAuthorship W4385225535A5070797410 @default.
• W4385225535 hasAuthorship W4385225535A5080122735 @default.
• W4385225535 hasBestOaLocation W43852255351 @default.
• W4385225535 hasConcept C126322002 @default.
• W4385225535 hasConcept C151032500 @default.
• W4385225535 hasConcept C191237925 @default.
• W4385225535 hasConcept C2776694085 @default.
• W4385225535 hasConcept C2777397205 @default.
• W4385225535 hasConcept C2777495988 @default.
• W4385225535 hasConcept C2777953023 @default.
• W4385225535 hasConcept C2778233292 @default.
• W4385225535 hasConcept C2781303535 @default.
• W4385225535 hasConcept C29730261 @default.
• W4385225535 hasConcept C63645605 @default.
• W4385225535 hasConcept C71924100 @default.
• W4385225535 hasConcept C84393581 @default.

• next