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- W4385230275 abstract "Abstract Objectives Investigating the relationship between liver enzymes, uric acid (UA), and macrosomia will benefit physicians in the early detection of complications that may emerge during/after pregnancy. The study analyzed liver enzyme activity and UA levels in first-trimester pregnant for the risk of macrosomia. Methods This retrospective cross-sectional research analyzed the data of pregnant women who gave birth between Jan 2021–2023. All data were extracted from medical records, and UA and AST-ALT were examined in all the participants. Results Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were higher in the macrosomia (p<0.05). Similarly, UA levels were higher in the macrosomia (p<0.001). There was a moderate positive correlation between ALT and birth weight (r=0.168, p<0.01), while we found a strong positive correlation between UA and birth weight (r=0.355, p<0.01). In the ROC (receiver operating characteristic), Area Under the Curve (AUC) for ALT and UA was significant (p<0.0001) but not for AST (p=0.157). UA showed a predictive value for macrosomia with 68.1 % sensitivity and 63.8 % specificity at a 3.15 cut-off (AUC:0.689; p:0.0001; CI:0.644–0.725). Conclusions These results indicate that ALT and UA may be potentially important in determining the risk of macrosomia. The UA had a more potent marker for macrosomia than ALT. The occurrence of macrosomia might be more closely related to the mother’s metabolic syndrome rather than NAFLD." @default.
- W4385230275 created "2023-07-26" @default.
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- W4385230275 date "2023-07-26" @default.
- W4385230275 modified "2023-10-17" @default.
- W4385230275 title "Comprehensive analysis of macrosomia: exploring the association between first-trimester alanine aminotransferase and uric acid measurements in pregnant women" @default.
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- W4385230275 doi "https://doi.org/10.1515/jpm-2023-0199" @default.
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