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- W4385230369 abstract "Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with poor prognosis due to early metastasis, low diagnostic rates at early stages, and resistance to current therapeutic regimens. Despite numerous studies and clinical trials, the mortality rate for PDAC has shown limited improvement. Therefore, there is a pressing need to attain. a more comprehensive molecular characterization to identify biomarkers enabling early detection and evaluation of treatment response. MicroRNA (miRNAs) are critical regulators of gene expression on the post-transcriptional level, and seem particularly interesting as biomarkers due to their relative stability, and the ability to detect them in fixed tissue specimens and biofluids. Deregulation of miRNAs is common and affects several hallmarks of cancer and contribute to the oncogenesis and metastasis of PDAC. Unique combinations of upregulated oncogenic miRNAs (oncomiRs) and downregulated tumor suppressor miRNAs (TsmiRs), promote metastasis, characterize the tumor and interfere with chemosensitivity of PDAC cells. Here, we review several oncomiRs and TsmiRs involved in chemoresistance to gemcitabine and FOLFIRINOX in PDAC and highlighted successful/effective miRNA-based therapy approaches in vivo. Integrating miRNAs in PDAC treatment represents a promising therapeutic avenue that can be used as guidance for personalized medicine for PDAC patients." @default.
- W4385230369 created "2023-07-26" @default.
- W4385230369 creator A5035296183 @default.
- W4385230369 creator A5041229832 @default.
- W4385230369 creator A5043933789 @default.
- W4385230369 creator A5092776770 @default.
- W4385230369 creator A5092776771 @default.
- W4385230369 date "2023-07-25" @default.
- W4385230369 modified "2023-09-30" @default.
- W4385230369 title "Targeting miRNA and using miRNA as potential therapeutic options to bypass resistance in pancreatic ductal adenocarcinoma" @default.
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- W4385230369 doi "https://doi.org/10.1007/s10555-023-10127-w" @default.
- W4385230369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37490255" @default.
- W4385230369 hasPublicationYear "2023" @default.
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