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• W4385230884 abstract "The mesenchymal-epithelial transition factor (MET) exon 14 skipping mutation is mainly caused by the loss of c-Cbl tyrosine binding site. This mutation could result in a decrease in the degradation rate of proteasome-mediated MET proteins, trigger continuous activation of downstream pathways, and ultimately lead to tumorigenesis. The incidence of MET exon 14 skipping mutation in patients with non-small cell lung cancer (NSCLC) is 0.9% to 4.0%. Patients with advanced NSCLC are recommended to test MET exon 14 skipping mutations who may benefit from MET inhibitors-targeted therapy. MET inhibitors have a high objective response rate and good safety profiles, which could prolong the survival of NSCLC patients with MET exon 14 skipping mutations. The Lung Cancer Specialty Committee of Chinese Elderly Health Care Association organized multidisciplinary experts to give suggestions on the important issues of clinical aspects for targeted therapy of MET exon 14 skipping mutation in NSCLC according to the clinical practice experiences and evidences based medicine. Expert Consensus on Targeted Therapy of NSCLC with MET Exon 14 Skipping Mutation is proposed, aiming to provide standardized guidances for the clinical practice of Chinese physicians. .【中文题目：MET 14外显子跳跃突变NSCLC靶向治疗 专家共识】 【中文摘要：间质-上皮细胞转化因子（mesenchymal-epithelial transition factor, MET）14外显子跳跃突变主要由于c-Cbl酪氨酸结合位点丢失导致，从而引起蛋白酶体介导的MET蛋白降解率降低，引发下游通路的持续激活，最终导致肿瘤发生。非小细胞肺癌（non-small cell lung cancer, NSCLC）患者中MET 14外显子跳跃突变的发生率为0.9%-4.0%，晚期NSCLC患者应进行MET 14外显子跳跃突变的检测，以筛选MET抑制剂靶向治疗获益人群。MET抑制剂客观缓解率均较高，安全性良好，为MET 14外显子跳跃突变NSCLC患者带来新希望。中国老年保健协会肺癌专业委员会组织专家结合临床实践经验及循证医学证据，针对MET 14外显子跳跃突变NSCLC靶向治疗的临床问题给予专家建议，制定《MET 14外显子跳跃突变NSCLC靶向治疗专家共识》，旨在为中国医师的临床实践提供规范化指导。 】 【中文关键词：肺肿瘤；MET 14外显子跳跃突变；MET抑制剂；靶向治疗】." @default.
• W4385230884 created "2023-07-26" @default.
• W4385230884 date "2023-06-20" @default.
• W4385230884 modified "2023-09-29" @default.
• W4385230884 title "[Expert Consensus on Targeted Therapy of NSCLC with MET Exon 14 
Skipping Mutation]." @default.
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• W4385230884 doi "https://doi.org/10.3779/j.issn.1009-3419.2023.102.19" @default.
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