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- W4385230976 abstract "Abstract Although acid‐sensing ion channels (ASICs) are proton‐gated ion channels responsible for sensing tissue acidosis, accumulating evidence has shown that ASICs are also involved in neurosensory mechanotransduction. However, in contrast to Piezo ion channels, evidence of ASICs as mechanically gated ion channels has not been found using conventional mechanoclamp approaches. Instead, ASICs are involved in the tether model of mechanotransduction, with the channels gated via tethering elements of extracellular matrix and intracellular cytoskeletons. Methods using substrate deformation‐driven neurite stretch and micropipette‐guided ultrasound were developed to reveal the roles of ASIC3 and ASIC1a, respectively. Here we summarize the evidence supporting the roles of ASICs in neurosensory mechanotransduction in knockout mouse models of ASIC subtypes and provide insight to further probe their roles in proprioception. New Findings What is the topic of this review? The roles of acid‐sensing ion channels in mechanotransduction, including proprioception, along with new investigative approaches. What advances does it highlight? New methods such as substrate deformation‐driven neurite stretch and micropipette‐guided ultrasound can help in studying the functions and electrophysiological properties of ASICs essential for a tether model of mechanotransduction, especially conduction of proprioceptive signals from the muscle spindle to specific groups of dorsal root ganglion neurons." @default.
- W4385230976 created "2023-07-26" @default.
- W4385230976 creator A5037765341 @default.
- W4385230976 creator A5045135582 @default.
- W4385230976 creator A5049274840 @default.
- W4385230976 creator A5090783908 @default.
- W4385230976 date "2023-07-25" @default.
- W4385230976 modified "2023-10-18" @default.
- W4385230976 title "Genetic exploration of roles of acid‐sensing ion channel subtypes in neurosensory mechanotransduction including proprioception" @default.
- W4385230976 cites W1542498459 @default.
- W4385230976 cites W1546862061 @default.
- W4385230976 cites W1547594413 @default.
- W4385230976 cites W1556204135 @default.
- W4385230976 cites W1966272280 @default.
- W4385230976 cites W1975461211 @default.
- W4385230976 cites W1976797634 @default.
- W4385230976 cites W1978900863 @default.
- W4385230976 cites W1981256630 @default.
- W4385230976 cites W1982059504 @default.
- W4385230976 cites W1985365801 @default.
- W4385230976 cites W1990815583 @default.
- W4385230976 cites W1993386867 @default.
- W4385230976 cites W1994746494 @default.
- W4385230976 cites W1997628943 @default.
- W4385230976 cites W1999264674 @default.
- W4385230976 cites W2001537814 @default.
- W4385230976 cites W2002760577 @default.
- W4385230976 cites W2006709274 @default.
- W4385230976 cites W2015652944 @default.
- W4385230976 cites W2015902564 @default.
- W4385230976 cites W2017861431 @default.
- W4385230976 cites W2021524071 @default.
- W4385230976 cites W2024030576 @default.
- W4385230976 cites W2028102100 @default.
- W4385230976 cites W2029966635 @default.
- W4385230976 cites W2032987534 @default.
- W4385230976 cites W2033072655 @default.
- W4385230976 cites W2033885622 @default.
- W4385230976 cites W2040831160 @default.
- W4385230976 cites W2047283239 @default.
- W4385230976 cites W2048869654 @default.
- W4385230976 cites W2056045458 @default.
- W4385230976 cites W2056958822 @default.
- W4385230976 cites W2064147649 @default.
- W4385230976 cites W2067079444 @default.
- W4385230976 cites W2073961593 @default.
- W4385230976 cites W2076550876 @default.
- W4385230976 cites W2081317765 @default.
- W4385230976 cites W2082728758 @default.
- W4385230976 cites W2087868042 @default.
- W4385230976 cites W2091040495 @default.
- W4385230976 cites W2092614177 @default.
- W4385230976 cites W2102880206 @default.
- W4385230976 cites W2104659034 @default.
- W4385230976 cites W2104984002 @default.
- W4385230976 cites W2107634021 @default.
- W4385230976 cites W2107988902 @default.
- W4385230976 cites W2109748103 @default.
- W4385230976 cites W2123595873 @default.
- W4385230976 cites W2126534910 @default.
- W4385230976 cites W2130514716 @default.
- W4385230976 cites W2134183388 @default.
- W4385230976 cites W2135064193 @default.
- W4385230976 cites W2136591269 @default.
- W4385230976 cites W2137620073 @default.
- W4385230976 cites W2151301539 @default.
- W4385230976 cites W2157779792 @default.
- W4385230976 cites W2159323746 @default.
- W4385230976 cites W2164065779 @default.
- W4385230976 cites W2173426800 @default.
- W4385230976 cites W2184968222 @default.
- W4385230976 cites W2233345494 @default.
- W4385230976 cites W2328886268 @default.
- W4385230976 cites W2337789656 @default.
- W4385230976 cites W2354944428 @default.
- W4385230976 cites W2525001998 @default.
- W4385230976 cites W2528253367 @default.
- W4385230976 cites W2546599230 @default.
- W4385230976 cites W2767554822 @default.
- W4385230976 cites W2792127002 @default.
- W4385230976 cites W2806992211 @default.
- W4385230976 cites W2896255684 @default.
- W4385230976 cites W2903552809 @default.
- W4385230976 cites W3036778761 @default.
- W4385230976 cites W3081439242 @default.
- W4385230976 cites W3100537556 @default.
- W4385230976 cites W3132551082 @default.
- W4385230976 cites W3134688988 @default.
- W4385230976 cites W3159526093 @default.
- W4385230976 cites W3189580243 @default.
- W4385230976 cites W3195953722 @default.
- W4385230976 cites W3202968829 @default.
- W4385230976 cites W4220783590 @default.
- W4385230976 cites W4248137354 @default.
- W4385230976 cites W4308144426 @default.
- W4385230976 cites W4360600347 @default.
- W4385230976 cites W4377101012 @default.
- W4385230976 doi "https://doi.org/10.1113/ep090762" @default.
- W4385230976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37489658" @default.
- W4385230976 hasPublicationYear "2023" @default.