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• W4385231111 abstract "Emerging evidence has demonstrated that obesity impacts multiple immune-related diseases. It remains unclear whether and how obesity alters treatment outcomes in patients with primary immune thrombocytopenia (ITP). Thus, we retrospectively investigated 214 treatment-naïve patients who received standard high-dose dexamethasone therapy in Qilu Hospital. Patients with obesity showed significantly lower overall initial response (underweight vs. normal vs. overweight vs. obese: 85.7% vs. 85.2% vs. 72.0% vs. 52.3%, p = 0.001) and initial complete response ([CR], 71.4% vs. 70.4% vs. 53.3% vs. 27.3%, p < 0.001) rates. The same trend was observed in the 6-month sustained response (63.6% vs. 52.3% vs. 35.6% vs. 22.7%, p = 0.03) and sustained CR (36.4% vs. 44.6% vs. 24.4% vs. 9.1%, p = 0.01). The Kaplan-Meier analysis revealed a shortened duration of remission in the obese group (median duration of remission, not reached vs. 16 months vs. 2 months vs. 1 month, p = 0.002). In multivariate regression analysis, obesity was independently associated with poor initial and sustained responses, and an increased risk for relapse. In conclusion, obesity is a negative predictor for outcomes of corticosteroid treatment. A stratified strategy according to body mass index status may facilitate the precision management of ITP." @default.
• W4385231111 created "2023-07-26" @default.
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• W4385231111 date "2023-07-24" @default.
• W4385231111 modified "2023-10-14" @default.
• W4385231111 title "Obesity is associated with poor outcomes of corticosteroid treatment in patients with primary immune thrombocytopenia" @default.
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• W4385231111 doi "https://doi.org/10.1111/bjh.18997" @default.
• W4385231111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37488467" @default.
• W4385231111 hasPublicationYear "2023" @default.
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