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- W4385231657 endingPage "114590" @default.
- W4385231657 startingPage "114590" @default.
- W4385231657 abstract "Synaptic dysfunction underlies many neurodevelopmental disorders (NDDs). The membrane-associated mucin domain-containing glycosylphosphatidylinositol anchor proteins (MDGAs) regulate synaptic development by modulating neurexin–neuroligin complex formation. Since understanding the neurodevelopmental profile and the sex-based differences in the manifestation of the symptoms of NDDs is important for their early diagnosis, we tested a mouse model haploinsufficient for MDGA2 (MDGA2+/-) on a neurodevelopmental test battery, containing sensory, motor, and cognitive measures, as well as ultrasonic vocalizations. When male and female MDGA2+/- and wildtype (WT) C57BL/6 J mice were examined from 2 to 23 days of age using this test battery, genotype and sex differences in body weight, sensory-motor processes, and ultrasonic vocalizations were observed. The auditory startle reflex appeared earlier in the MDGA2+/- than in WT mice and the MDGA2+/- mice produced fewer ultrasonic vocalizations. The MDGA2+/- mice showed reduced locomotion and rearing than WT mice in the open field after 17 days of age and spent less time investigating a novel object than WT mice at 21 days of age. Female MDGA2+/- mice weighed less than WT females and showed lower grip strength, indicating a delay in sensory-motor development in MDGA2+/- mice, which appears to be more pronounced in females than males. The behavioural phenotypes resulting from MDGA2 haploinsufficiency suggests that it shows delayed development of motor behaviour, grip strength and exploratory behaviour, non-social phenotypes of NDDs." @default.
- W4385231657 created "2023-07-26" @default.
- W4385231657 creator A5017189593 @default.
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- W4385231657 creator A5078827118 @default.
- W4385231657 creator A5080350890 @default.
- W4385231657 creator A5092536748 @default.
- W4385231657 date "2023-08-01" @default.
- W4385231657 modified "2023-09-27" @default.
- W4385231657 title "Early postnatal development of the MDGA2+/- mouse model of synaptic dysfunction" @default.
- W4385231657 cites W1512190845 @default.
- W4385231657 cites W1558137567 @default.
- W4385231657 cites W1568828319 @default.
- W4385231657 cites W1590571258 @default.
- W4385231657 cites W1965141574 @default.
- W4385231657 cites W1968044148 @default.
- W4385231657 cites W1971341839 @default.
- W4385231657 cites W1971512830 @default.
- W4385231657 cites W1971676092 @default.
- W4385231657 cites W1980505500 @default.
- W4385231657 cites W1983894784 @default.
- W4385231657 cites W1988011192 @default.
- W4385231657 cites W1990581042 @default.
- W4385231657 cites W1992667293 @default.
- W4385231657 cites W1997061523 @default.
- W4385231657 cites W1997469637 @default.
- W4385231657 cites W2006079595 @default.
- W4385231657 cites W2012796647 @default.
- W4385231657 cites W2014756302 @default.
- W4385231657 cites W2019890913 @default.
- W4385231657 cites W2024521989 @default.
- W4385231657 cites W2026362661 @default.
- W4385231657 cites W2028888536 @default.
- W4385231657 cites W2037783396 @default.
- W4385231657 cites W2042076636 @default.
- W4385231657 cites W2049025590 @default.
- W4385231657 cites W2053496010 @default.
- W4385231657 cites W2053666202 @default.
- W4385231657 cites W2059569187 @default.
- W4385231657 cites W2062981060 @default.
- W4385231657 cites W2063815643 @default.
- W4385231657 cites W2064683298 @default.
- W4385231657 cites W2068194860 @default.
- W4385231657 cites W2070390803 @default.
- W4385231657 cites W2071797996 @default.
- W4385231657 cites W2074154809 @default.
- W4385231657 cites W2078771842 @default.
- W4385231657 cites W2081829075 @default.
- W4385231657 cites W2084057859 @default.
- W4385231657 cites W2087484885 @default.
- W4385231657 cites W2092689561 @default.
- W4385231657 cites W2104301336 @default.
- W4385231657 cites W2106170163 @default.
- W4385231657 cites W2108994842 @default.
- W4385231657 cites W2109642486 @default.
- W4385231657 cites W2110741989 @default.
- W4385231657 cites W2114928393 @default.
- W4385231657 cites W2120275603 @default.
- W4385231657 cites W2120312409 @default.
- W4385231657 cites W2125432692 @default.
- W4385231657 cites W2125531274 @default.
- W4385231657 cites W2126726129 @default.
- W4385231657 cites W2130157722 @default.
- W4385231657 cites W2132735284 @default.
- W4385231657 cites W2146538063 @default.
- W4385231657 cites W2147140183 @default.
- W4385231657 cites W2151423922 @default.
- W4385231657 cites W2152107254 @default.
- W4385231657 cites W2153617971 @default.
- W4385231657 cites W2157102783 @default.
- W4385231657 cites W2160242809 @default.
- W4385231657 cites W2162843814 @default.
- W4385231657 cites W2170760271 @default.
- W4385231657 cites W2203075646 @default.
- W4385231657 cites W2226587564 @default.
- W4385231657 cites W2228897227 @default.
- W4385231657 cites W2232961165 @default.
- W4385231657 cites W2288241310 @default.
- W4385231657 cites W2314186910 @default.
- W4385231657 cites W2431917041 @default.
- W4385231657 cites W2486115624 @default.
- W4385231657 cites W2517203168 @default.
- W4385231657 cites W2518622778 @default.
- W4385231657 cites W2558948590 @default.
- W4385231657 cites W2564632590 @default.
- W4385231657 cites W2570780327 @default.
- W4385231657 cites W2622484033 @default.
- W4385231657 cites W2731941380 @default.
- W4385231657 cites W2745968167 @default.
- W4385231657 cites W2754116193 @default.
- W4385231657 cites W2765792294 @default.
- W4385231657 cites W2769544142 @default.
- W4385231657 cites W2790173628 @default.
- W4385231657 cites W2790470032 @default.
- W4385231657 cites W2790747757 @default.
- W4385231657 cites W2790825542 @default.